Ask about this productRelated genes to: GNGT2 Blocking Peptide
- Gene:
- GNGT2 NIH gene
- Name:
- G protein subunit gamma transducin 2
- Previous symbol:
- -
- Synonyms:
- GNG9
- Chromosome:
- 17q21
- Locus Type:
- gene with protein product
- Date approved:
- 1988-04-28
- Date modifiied:
- 2016-03-03
Related products to: GNGT2 Blocking Peptide
Related articles to: GNGT2 Blocking Peptide
- Myopia has become a major public health issue, and abnormal retinal tissue function is widely recognized as a key factor in its occurrence and development. Existing studies have shown that electroacupuncture (EA) intervention can significantly inhibit the progression of myopia, but the specific cellular mechanisms by which EA regulates retinal cell function remain unclear. In this study, single-cell RNA sequencing (scRNA-seq) technology was used to systematically explore the effects of EA on the functional characteristics of various retinal cells in myopic guinea pigs. The research methods are as follows: Based on scRNA-seq data, inter-group metabolic differences were analyzed through scMetabolism; the functional significance of differentially expressed genes was evaluated by gene set enrichment analysis (GSEA); core genes were screened by high-dimensional weighted co-expression network analysis (Hd-WGCNA) and pseudo-time trajectory analysis; and the expression levels of core genes were verified by real-time fluorescence quantitative polymerase chain reaction (qPCR) and Western blotting experiments. The results show that EA treatment can alleviate the oxidative stress response induced by myopia, enhance intercellular communication, and thereby maintain retinal homeostasis. At the same time, it can significantly improve the phototransduction dysfunction of cone cells related to myopia, mainly by regulating the abnormal expression of PDE6H and GNGT2 genes. In addition, EA can also regulate the expression of the DBI gene in Müller glial cells (MG) and promote the dynamic state transition of microglia, inhibiting their inflammation-responsive phenotype, thereby inhibiting the expression of IL-1β and reducing the inflammatory response. In conclusion, this study systematically clarified the effects of EA treatment on MG, photoreceptor cone cells and microglia in the retina of myopic guinea pigs, providing new insights into the mechanism by which EA alleviates the progression of myopia. - Source: PubMed
Publication date: 2026/03/02
Li ZhanglongHan XudongXi RuofanWang JunmingChen XinyueBi HongshengZhao Ping - Spinal cord injury (SCI) is a devastating disorder featuring serious motor dysfunction and proprioceptive deficits due to central nervous system (CNS) damage. During its progression, macrophage-microglia (MM) cells are rapidly activated and play pivotal roles in the inflammatory response through various mechanisms. However, limited research has investigated the differential gene expression between the two groups before and after injury, and these important genes may therefore serve as potential biological diagnostic markers. - Source: PubMed
Publication date: 2025/09/10
Zheng ManyiJiang YunduoLiu FangyuWang Yansong - Inherited retinal degenerations (IRDs) cause progressive photoreceptor loss, leading to vision impairment. Gene therapy using adeno-associated viral (AAV) vectors holds immense promise for treating these conditions. However, achieving optimal gene expression at mid to late stages of retinal degeneration remains challenging due to scarcity of efficient photoreceptor-specific promoters expressed at these disease stages. This study aimed to identify and validate novel promoters capable of robust and specific transgene expression when ≥50% of photoreceptors are lost. Analysis of transcriptomic data from two naturally occurring canine IRD models, laser capture microdissection of retinal cryosections followed by qPCR, and RNA in situ hybridization identified six promising genes with sustained or upregulated expression in photoreceptors in late-stage disease. Upstream cis-regulatory elements of both canine and human orthologs were identified and characterized using in silico analyses and dual-luciferase assays. Short promoters (≤840 base pairs) derived from GNGT2, IMPG2, and PDE6H genes exhibited robust reporter gene expression in photoreceptors when delivered via AAV to the subretinal space of two non-allelic canine IRD models at mid and late disease stages. These findings provide a strategy to enhance AAV-mediated gene therapy by enabling sustained transgene expression in degenerating retinas, improving treatment outcomes for patients with progressive vision loss. - Source: PubMed
Publication date: 2025/05/21
Sudharsan RaghaviMurgiano LeonardoAhuja AditiSato YuKwok JenniferDolgova NataliaSavina SvetlanaSedorovitz MorganDufour Valerie LAguirre Gustavo DByrne Leah CBeltran William A - Asthma is a heterogeneous inflammatory disease with two main clinical endotypes: type 2 (T2) high and low asthma. The plasticity and autophagy in dendritic cells (DCs) influence T helper (Th)2 or Th17 differentiation to regulate asthma endotypes. Enhanced autophagy in DCs fosters Th2 differentiation in allergic environments, while reduced autophagy favors Th17 cell differentiation in sensitized and infected environments. Autophagy regulation in DCs involves interaction with various pathways like G protein-coupled receptor (GPCR), mammalian target of rapamycin (mTOR), or phosphoinositide 3-kinase (PI3K) pathway. However, specific molecules within DCs influencing asthma endotypes remain unclear. - Source: PubMed
Ji XiaoyingZhou YaoliangHe ShendongChen HongdaZhang XianmingChen ZhifengCai Jinwen - Inhaled corticosteroids (ICS) are efficacious in the treatment of asthma, which affects more than 300 million people in the world. While genome-wide association studies have identified genes involved in differential treatment responses to ICS in asthma, few studies have evaluated the effects of combined rare and common variants on ICS response among children with asthma. Among children with asthma treated with ICS with whole exome sequencing (WES) data in the PrecisionLink Biobank (91 White and 20 Black children), we examined the effect and contribution of rare and common variants with hospitalizations or emergency department visits. For 12 regions previously associated with asthma and ICS response (, , , , , , , , , , ), we used the combined sum test for the sequence kernel association test (SKAT) adjusting for age, sex, and BMI and stratified by race. Validation was conducted in the Biorepository and Integrative Genomics (BIG) Initiative (83 White and 134 Black children). Using a Bonferroni threshold for the 12 regions tested (i.e., 0.05/12 = 0.004), was significantly associated with ICS response for the combined effect of rare and common variants (-value = 0.003) among White children in the PrecisionLink Biobank and replicated in the BIG Initiative (-value = 0.02). Using WES data, the combined effect of rare and common variants for was associated with ICS response among asthmatic children in the PrecisionLink Biobank and replicated in the BIG Initiative. This proof-of-concept study demonstrates the power of biobanks of pediatric real-life populations in asthma genomic investigations. - Source: PubMed
Publication date: 2024/03/28
Voorhies KirstenMohammed AkramChinthala LokeshKong Sek WonLee In-HeeKho Alvin TMcGeachie MichaelMandl Kenneth DRaby BenjaminHayes MelanieDavis Robert LWu Ann ChenLutz Sharon M