Ask about this productRelated genes to: FBXO21 Blocking Peptide
- Gene:
- FBXO21 NIH gene
- Name:
- F-box protein 21
- Previous symbol:
- -
- Synonyms:
- FBX21, KIAA0875
- Chromosome:
- 12q24.22
- Locus Type:
- gene with protein product
- Date approved:
- 2000-09-27
- Date modifiied:
- 2016-10-05
Related products to: FBXO21 Blocking Peptide
Related articles to: FBXO21 Blocking Peptide
- - Source: PubMed
Publication date: 2026/04/29
Gao JieYao HuibaoMao QianchengLiu ChuCui YuanshanZhao JunjieMa JianWu Jitao - Acute kidney injury (AKI) is a serious disease with a high incidence and easy induction. The search for innovative biomarkers and treatment methods is of great significance for improving the prognosis of patients. Autophagy is closely related to the occurrence and development of AKI. This study aims to explore the role of autophagy-related genes (ARGs) as potential biomarkers and therapeutic targets in AKI. - Source: PubMed
Publication date: 2026/02/02
Bai YunqiZhang LiliNie BoSu YixinZhou Jingwei - NMNAT2 is an essential but labile protein required for axon integrity. It is rapidly degraded after nerve injury, promoting axon degeneration. However, the mechanisms regulating NMNAT2 ubiquitination and turnover in neurons remain unclear. In this study, we identify the F-box protein FBXO21 as an NMNAT2-binding protein, and its deficiency confers axonal protection via increasing NMNAT2 abundance. FBXO21 recruits SKP1, CUL1, and RBX1 to form an SCFFBXO21 complex, which promotes NMNAT2 ubiquitination in vivo and in vitro. SCFFBXO21 ubiquitinates NMNAT2 at K155 within an isoform-specific targeting and interaction domain of the family of NMNATs, which underlies the unique labile nature of NMNAT2. The ubiquitination-deficient NMNAT2-K155R exhibits substantially reduced protein turnover and enhanced axon-protective capacity. Finally, in Fbxo21 knockout mice, NMNAT2 levels are markedly increased and the survival of injured sciatic nerves is significantly prolonged. Collectively, our findings reveal a crucial role of FBXO21 in axon degeneration, highlighting the SCFFBXO21 complex as a potential target for modulating NMNAT2-dependent axon survival. - Source: PubMed
Publication date: 2025/09/30
Long WenjingLi ShunyiWang QiangqiangYue WenkaiFu YanbinWang HaiqiongJiang MingshengHu XianyanLi YunxiaCui JihongLi AngZhang YaoyangZhang ZairongFang Yanshan - The mechanism by which circRERE (hsa_circ_0006837) modulates the malignant progression of gastric cancer was investigated to identify a novel biomarker and therapeutic target for this disease. - Source: PubMed
Publication date: 2025/05/22
He YanxinSun YeyuZheng YinglanJiang YanfangLi NaZhao WenjieRen Wanhua - - Source: PubMed
Publication date: 2025/04/11
Long Jiaorong