Ask about this productRelated genes to: MAPKAPK3 Blocking Peptide
- Gene:
- MAPKAPK3 NIH gene
- Name:
- MAPK activated protein kinase 3
- Previous symbol:
- -
- Synonyms:
- 3pK, MAPKAP3, 3PK
- Chromosome:
- 3p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-03-26
- Date modifiied:
- 2019-04-12
Related products to: MAPKAPK3 Blocking Peptide
Related articles to: MAPKAPK3 Blocking Peptide
- Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder with incompletely elucidated underlying biological mechanisms. Circulating proteins serve as an intermediate molecular layer linking genetic variation to downstream biological processes. This study aimed to systematically investigate the causal associations between the plasma proteome and ASD risk, followed by multi-omic and clinical validation. - Source: PubMed
Publication date: 2026/04/24
Wang LihongLiu TianciYu LianhuLiu ZhiyueChe ChaoYu XiaoxiaoCai ZhifengCao Aihua - Selective pressures, both natural and artificial, have significantly influenced the genomic architecture of domesticated sheep. Understanding their underlying molecular mechanisms is critical for developing efficient breeding programs to conserve and improve economically important traits in native breeds. In this study, we analysed high-density 50K SNP data from three Indigenous sheep breeds: Chanthangi (CHA, n = 29), Garole (GAR, n = 24), and Deccani (IDC, n = 26), each native to diverse climatic regions of India. We implemented a novel SNP-based de-correlated composite of multiple signals (DCMS) statistic, which integrates p-values from five selection metrics viz., FST, H1, H12, Tajima's D, and nucleotide diversity (π) into a unified measure. The SNP-based DCMS approach offers finer resolution and complements window-based methods by enabling more precise localisation of selection signals and candidate genes. Multiple testing correction was applied at a False Discovery Rate (FDR) threshold of <5% to detect significant genomic regions. Comprehensive gene and quantitative trait loci (QTL) annotation and enrichment analysis of these regions were also performed for each breed. The DCMS analysis identified 21, 10, and 14 novel and breed-specific putative genes in the Chanthangi, Garole, and Deccani breeds, respectively, as well as 10, 28, and 13breed-specific QTL regions. The identified genes and QTLs are associated with diverse phenotypic traits, including growth and muscle development (CNTNAP5, DOCK3), reproduction (TCERG1L, BUB1, UNC5C, C2CD5, BBX), wool trait (TPPP3, P2RY6, FGF10, POU2F1, FAM168A), disease resistance (MTSS1, B4GALNT3), environment adaptation (TRMT12, MAPKAPK3), domestication (LRRC36). The QTLs identified are associated with body conformation (body measurements and bone area), production (milk fat yield), reproduction (total lambs born), disease resistance (hemonchus resistance, foot rot, and pneumonia susceptibility), and health (platelet count and entropion). Our SNP-based DCMS method enabled high-resolution detection of breed-specific selection signatures. It facilitated the discovery of both known and novel genomic regions, candidate genes, and QTLs unique to Indian sheep breeds. This comprehensive approach provides valuable insights into the molecular mechanisms underlying economically important traits and offers a robust foundation for targeted genetic improvement and conservation of indigenous sheep breeds. - Source: PubMed
Publication date: 2026/03/25
Nath SapnaIlla Satish KumarWorku DestawMukherjee SabyasachiMukherjee AnupamaYata Vinod Kumar - To report a rare case of Down-Klinefelter syndrome associated with bilateral congenital posterior polar cataracts and a novel gene mutation. A single case was reviewed. A 2-month-old male neonate presented with dysmorphic features, including a flat facial profile, low-set ears, and upslanting palpebral fissures, along with bilateral absence of the red reflex. Ocular examination revealed bilateral congenital posterior polar cataracts. Genetic testing confirmed Down-Klinefelter syndrome (48,XXY,+21) and identified a novel mutation in the MAPK-activated protein kinase 3 gene (MAPKAPK3, c.1039G>A, p.Asp347Asn). While characteristic features of Down syndrome were evident, manifestations of Klinefelter syndrome were not yet apparent owing to the patient's young age. The patient underwent bilateral pars plana vitrectomy and lensectomy to prevent the development of nystagmus, amblyopia, and strabismus. Down-Klinefelter syndrome (48,XXY,+21) is a rare chromosomal disorder. This case is notable for the coexistence of classic Down syndrome features, genomic confirmation of Klinefelter syndrome, and a previously unreported mutation. Close and long-term follow-up will be essential to understand the clinical implications of this unique genetic combination. - Source: PubMed
Publication date: 2026/02/28
Arias-González NancyBalikov Daniel ACiccioli MarcelaNegron Catherin IHua Hong-UyenMalek Davina ABerrocal Audina M - The Mitogen-Activated Protein Kinase (MAPK) signaling pathway is significant in clinical practice for its potential to impede tumor proliferation and migration and to enhance patient prognosis. Yet, the specific contributions of MAPK-related genes to the prognosis of colorectal cancer (CRC) are not clear. - Source: PubMed
Hou HuixuanZhang LongDuan Hualing - Previous studies have shown that miR-5110 regulates pigmentation by cotargeting melanophilin (MLPH) and WNT family member 1 (WNT1). In order to find the possible molecular mechanism for pigmentation, we examined the mRNA expression profiles in melanocytes of alpaca transfected with miR-5110, inhibitor or negative control (NC) plasmids using high-throughput RNA sequencing. The results showed that a total of 91,976 unigenes were assembled from the reads, among which 13,262 had sequence sizes greater than 2000 nucleotides. According to the KEGG pathway analysis, four pathways related to melanogenesis, the MAPK signaling pathway, Wnt signaling pathway, and cAMP signaling pathway were identified. Compared to the NC, 162 gene were upregulated and 41 genes were downregulated in melanocytes over expressed by miR-5110. The differential expressions of mRNAs Dickkopf 3 (), premelanosome protein (), insulin-like growth factor 1 receptor (), cyclin-dependent kinase 5 (), endothelin receptor type B (), kit ligand (), , and were verified using qRT-PCR, which agreed with the results of RNA sequencing. We also verified the differential expressions of mRNAs of some genes in the MAPK signaling pathway using qRT-PCR, which agreed with the results of RNA sequencing. Interestingly, several genes were screened as candidates for the melanogenesis regulated by miR-5110, including Kitl and MAPK-activated protein kinase 3 (). These findings provide new insights for further molecular studies on the effects of miR-5110 on the melanogenesis and pigmentation. - Source: PubMed
Publication date: 2026/01/16
Yang ShanshanJiao DingxingLi FengsaiWang XuqiSong TaoWang LiliRui PingMa Zengjun