Ask about this productRelated genes to: CCDC110 Blocking Peptide
- Gene:
- CCDC110 NIH gene
- Name:
- coiled-coil domain containing 110
- Previous symbol:
- -
- Synonyms:
- KM-HN-1, MGC33607, CT52
- Chromosome:
- 4q35.1
- Locus Type:
- gene with protein product
- Date approved:
- 2006-10-23
- Date modifiied:
- 2014-11-19
Related products to: CCDC110 Blocking Peptide
Related articles to: CCDC110 Blocking Peptide
- Hepatocellular carcinoma (HCC) is recognized for its high growth rate, high degree of invasiveness, and tendency to spread, leading to a significant number of deaths. In the course of studying the transcriptome of HCC tissues, the protein coiled-coil domain-containing 110 (CCDC110) was identified. By employing tandem mass tag (TMT) quantitative proteomics, this research identified transforming growth factor beta receptor 1 (TGFBR1) as a potential target influenced by CCDC110. The purpose of this study was to examine the role of CCDC110 in the growth and invasion of HCC and to identify new potential targets for the treatment of HCC. - Source: PubMed
Publication date: 2025/05/20
Shen HaoLi HaifengTang Haodong - Previous genome-wide association studies (GWAS) have established association between genetic variants and pulmonary function across various ethnics, whereas such associations are scarcely reported in Chinese adults. Therefore, we conducted an GWAS to explore relationships between genetic variants and pulmonary function among middle-aged Chinese dizygotic twins and further validated the top variants using data from the UK Biobank (UKB). - Source: PubMed
Publication date: 2024/12/30
Wang TongWang WeijingXu ChunshengTian XiaocaoZhang Dongfeng - Rare variants are believed to play a substantial role in the genetic architecture of mental disorders, particularly in coding regions. However, limited evidence supports the impact of rare variants on anxiety. - Source: PubMed
Publication date: 2023/12/26
Pan ChuyuCheng ShiqiangLiu LiChen YujingMeng PeilinYang XuenaLi Chun'eZhang JingxiZhang ZhenZhang HuijieCheng BolunWen YanJia YumengZhang Feng - Coiled-coil domain containing 110 (CCDC110, KM-HN-1) is a protein containing C-terminal coiled-coil domain (CCD) which was previously discovered as a member of the human cancer/testis antigen (CTA). In addition, CCDC110 has both nuclear localization signal sequence and the leucine zipper motif. Although the functional role of CCDC110 has yet to be fully identified, the mRNA expression levels of CCDC110 are known to be highly elevated in various cancer types including testis, implying its relevance to cancer pathogenesis. In this study, we first developed several monoclonal antibody (mAb) hybridoma clones targeting CCDC110 and further isolated clone by characterizing for its specificity using immunoblotting and immunoprecipitation approaches with basal parenchymal sperm cells in testis tissue. Next, using these mAbs, we showed that the Tet-inducible overexpression of CCDC110 protein delayed the entry of G2/M phase in U2-OS osteosarcoma cells. Based on these results, we propose that CCDC110 plays a crucial role in cell cycle progression. - Source: PubMed
Publication date: 2020/06/30
Lee Sue NyoungHong Kyeong-ManSeong Yeon SunKwak Sahng-June - Obesity and diabetes mellitus are directly implicated in many adverse health consequences in adults as well as in the offspring of obese and diabetic mothers. Hispanic Americans are particularly at risk for obesity, diabetes, and end-stage renal disease. Maternal obesity and/or diabetes through prenatal programming may alter the fetal epigenome increasing the risk of metabolic disease in their offspring. The aims of this study were to determine if maternal obesity or diabetes mellitus during pregnancy results in a change in infant methylation of CpG islands adjacent to targeted genes specific for obesity or diabetes disease pathways in a largely Hispanic population. - Source: PubMed
Publication date: 2020/02/19
Rizzo Heather EEscaname Elia NAlana Nicholas BLavender ElizabethGelfond JonathanFernandez RomanHibbs Matthew AKing Jonathan MCarr Nicholas RBlanco Cynthia L