Ask about this productRelated genes to: ZNF607 Blocking Peptide
- Gene:
- ZNF607 NIH gene
- Name:
- zinc finger protein 607
- Previous symbol:
- -
- Synonyms:
- MGC13071, FLJ14802
- Chromosome:
- 19q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-03-18
- Date modifiied:
- 2014-11-19
Related products to: ZNF607 Blocking Peptide
Related articles to: ZNF607 Blocking Peptide
- Paclitaxel is a microtubule-stabilizing drug that has been commonly used in treating cancer. Due to genetic heterogeneity within patient populations, therapeutic response rates often vary. Here we used the NCI60 panel to identify SNPs associated with paclitaxel sensitivity. Using the panel's GI50 response data available from Developmental Therapeutics Program, cell lines were categorized as either sensitive or resistant. PLINK software was used to perform a genome-wide association analysis of the cellular response to paclitaxel with the panel's SNP-genotype data on the Affymetrix 125 k SNP array. FastSNP software helped predict each SNP's potential impact on their gene product. mRNA expression differences between sensitive and resistant cell lines was examined using data from BioGPS. Using Haploview software, we investigated for haplotypes that were more strongly associated with the cellular response to paclitaxel. Ingenuity Pathway Analysis software helped us understand how our identified genes may alter the cellular response to paclitaxel. - Source: PubMed
Publication date: 2011/02/11
Eng LawsonIbrahim-zada IradaJarjanazi HamdiSavas SevtapMeschian MehranPritchard Kathleen IOzcelik Hilmi