Ask about this productRelated genes to: EIF4E2 Blocking Peptide
- Gene:
- EIF4E2 NIH gene
- Name:
- eukaryotic translation initiation factor 4E family member 2
- Previous symbol:
- EIF4EL3
- Synonyms:
- IF4e, 4EHP
- Chromosome:
- 2q37.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-22
- Date modifiied:
- 2015-08-25
Related products to: EIF4E2 Blocking Peptide
Related articles to: EIF4E2 Blocking Peptide
- Poxviruses have evolved robust immunoevasion strategies to facilitate replication in the cytosol. We previously reported that like several RNA viruses, vaccinia virus replication is impaired in the absence of the host cap-binding translation repressor protein 4EHP (eIF4E2), implicating the latter in host antiviral defense regulation and immunosuppression. Here, we show that the vaccinia virus-encoded K3L protein interacts with 4EHP via its obligatory binding partner GIGYF2 to increase the stability of the 4EHP/GIGYF2 complex. Consequently, K3L bolsters 4EHP/GIGYF2-mediated mRNA translation repression. Thus, we demonstrate that a 4EHP/GIGYF2-mediated mechanism is exploited by and conserved among RNA and DNA viruses as a potential immunoevasion strategy. Our findings document a 4EHP/GIGYF2-dependent stringent regulation of infection by poxviruses, a clinically important family of viruses that are employed as vaccine vectors and in oncolytic viral therapy. - Source: PubMed
Publication date: 2026/09/08
Ladak Reese JalalPelin AdrianZhuang HaotianAbboud ChelseaMahmood NiazBlanchet JonathanWu ChenyueHoang Huy-DungMcGirr TomMoshari AndiaMoustafa-Kamal MohamedSnell Patric HarrisDüsterhöft StefanBerghuis Albert MTrempe Jean-FrançoisTremblay Michel LTeodoro Jose GKhoutorsky ArkadyAlain TommyKrogan Nevan JChoi Jung-HyunJafarnejad Seyed MehdiSonenberg Nahum - The present study aimed to explore the difference and its underlying molecular mechanism of in ovo feeding (IOF) with Codonopsis pilosula polysaccharides (CPPS) on skeletal muscle in ducks. A total of 120 fertile eggs were randomly distributed into two treatment groups, with 6 replicates per group and 10 eggs per replicate. IOF was performed at incubation day 13 (I13). The control group was injected with 0.2 mL 0.75% sterile saline, while the CPPS group received 0.2 mL CPPS solution at a dose of 3 mg per egg. Breast muscle and leg muscle tissue samples were collected at I24 for multi-omics (transcriptomics, metabolomics and proteomics) analyses. In breast muscle, a total of 1301 differentially expressed genes (DEGs) were identified (497 upregulated and 804 downregulated). Genes involved in muscle development, such as creatine kinase, mitochondrial 2 (CKMT2, ENSAPLG00020008721) and G-protein signaling 4(RGS4, ENSAPLG00020014659), were significantly upregulated. For proteomics, 89 different expressed proteins (DEPs) were identified (44 upregulated and 45 downregulated), among which, Eukaryotic translation initiation factor 4E type 2 (eIF4E2, A0A8B9SQK7), myomesin 3 (A0A8B9ZBZ5), myogenic factor 6 (A0A8B9SGC1), myosin heavy chain and other myogenic-related proteins (MyHC, A0A8B9ZL15) related to muscle synthesis were markedly increased. Metabolomic analysis identified 1647 differential metabolites (DEMs), including 43 upregulated and 22 downregulated, with leucine being significantly decreased. Multi-omics integration revealed that these differential molecules were collectively enriched in the mTOR signaling pathway and glycerophospholipid metabolism pathway. These coordinated regulatory effects synergistically promoted breast muscle fiber development, enhanced energy metabolism, alleviated stress induced injury and ultimately improved skeletal muscle growth potential and meat quality. While in the leg muscles, 1195 DEGs were identified (487 upregulated and 708 downregulated), among which the expression of transcription factor 15 (TCF15, ENSAPLG00020006012), a gene associated with muscle development, was significantly upregulated. Proteomic analysis revealed 47 DEPs (15 upregulated and 32 downregulated), including phosphorus receptor protein (A0A8B9TCV3, PLN), mitofusin 1(A0A8B9TRP9, MFN1), titin(A0A8B9ZFJ8), which are closely related to muscle development and energy metabolism. Metabolomic analysis identified 1647 DEMs were identified (66 upregulated and 40 downregulated), with 5-Hydroxy-L-tryptophan (5-HTP), the precursor of serotonin (5-HT), significantly upregulated, providing substrates and energy for muscle development. Although no shared enriched pathway existed across the three omics in leg muscle, the differential molecules collectively suggest that IOF with CPPS supports energy supply for cell proliferation and creates a favorable environment for myogenesis. These findings help to elucidate the molecular mechanisms by which CPPS regulates embryonic skeletal muscle development. Moreover, the candidate genes, proteins and metabolites identified in this study may serve as valuable biomarkers and provide a potential nutritional strategy for improving meat quality traits in duck breeding. - Source: PubMed
Publication date: 2026/08/09
Liu AiRao YifuYue YongZhu JinjinWen JiyingYao BiqiongZhu YongcaiBoonanuntan SurintornYang Shenglin - Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive malignancy with limited options for early diagnosis and poor clinical outcomes. In the present study, PIWI‑interacting RNA (piR)‑164552 was identified as a novel oncogenic regulator in HNSCC. piR‑164552 was found to be markedly upregulated in tumor tissues and serum exosomes and its expression promoted the proliferation, migration, invasion and tumorigenicity of HNSCC cells both and . Mechanistic analyses revealed that piR‑164552 interacted with RNA‑binding motif protein 4 (RBM4) and positively regulated RBM4 protein levels, which in turn enhanced the expression of eukaryotic initiation factor 4E‑like 2 (EIF4E2), forming a piR‑164552/RBM4/EIF4E2 axis. Integrated transcriptomic and translatomic profiling further demonstrated that this axis orchestrated extensive reprogramming of mRNA metabolism, ribosome biogenesis and cancer‑associated signaling pathways, underscoring its multilayered role in tumor progression. The present findings highlighted the diagnostic potential of piR‑164552 and uncovered its key contribution to the molecular network driving HNSCC, providing new insights into biomarker development and therapeutic strategies. - Source: PubMed
Publication date: 2026/08/14
Yang ShanShang ZhenXia ShunxianLiu HongboDong YanhanWang XiaominXu WenhuaLu Haijun - Therapeutic resistance to DNA-damaging agents (DDAs) remains a primary obstacle in non-small cell lung cancer (NSCLC) treatment. Through multi-level analyses of clinical cohorts, cell lines, and derived resistant models, we identify eIF4E2 as a promising predictor of resistance to diverse DDAs. Using cisplatin as a model DDA, we find that eIF4E2 deficiency enhances DNA repair and promotes chemoresistance. Mechanistically, eIF4E2 represses translation of the DNA repair helicase WRN by recruiting the miRISC/CCR4-NOT complex to its 3'UTR via hsa-miR-130b-3p/301b-3p. Loss of eIF4E2 relieves WRN translation repression, potentiating DNA repair and attenuating DDA-induced DNA damage. Furthermore, combining the WRN inhibitor HRO761 with cisplatin enhances cytotoxicity in cisplatin-resistant cells. Collectively, these results establish that low eIF4E2 and high WRN levels predict chemoresistance, and that targeting WRN is a promising strategy to overcome cisplatin resistance in NSCLC. - Source: PubMed
Publication date: 2026/07/13
Lin XianrongZhang RuiTao WenjunWu YuxinHuang YifeiLi GuozhiSun JiajuZhang JunLiu Xiao-MinZhou Jun - mRNA translation and stability are tightly regulated and functionally linked through cis-acting sequence elements and trans-acting factors, including RNA-binding proteins (RBPs). Here, we report that two chordate-specific paralogous RBPs, ZC3H7A and ZC3H7B, preferentially bind the coding region (CDS) and 3' untranslated region (3' UTR) of A/U-rich mRNAs, particularly those with enrichment of A/U at their wobble sites (A/U3 codons). Upon binding to target mRNAs, ZC3H7A/B promote mRNA degradation through recruitment of the CCR4-NOT deadenylase complex. Furthermore, these proteins engage ribosomes lacking elongation factors and repress translation initiation via the GIGYF2/4EHP translation repressor complex. Depletion of ZC3H7A/B or 4EHP impairs the translational repression of A/U3-rich mRNAs. Together, these findings reveal a mechanism in higher eukaryotes that links A/U-rich sequence content within the CDS and 3' UTR to the coordinated post-transcriptional regulation of mRNA stability and translation. - Source: PubMed
Publication date: 2026/06/09
Harris Snell PatricNaeli ParisaGarzia AitorChen YanyuWaldron Joseph AChatterjee SusantaMcGirr TomKilmartin AidanMohammad Almomani Eman SuleimanKelsall Ian RLadak Reese JalalChoi Jung-HyunLuo JunLeino Sami AJess NaomiShariati S AliSoto XimenaGkogkas Christos GSonenberg NahumTuschl ThomasMaguire SarahJafarnejad Seyed Mehdi