Ask about this productRelated genes to: DIRAS1 Blocking Peptide
- Gene:
- DIRAS1 NIH gene
- Name:
- DIRAS family GTPase 1
- Previous symbol:
- -
- Synonyms:
- Di-Ras1, GBTS1, RIG
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-02-07
- Date modifiied:
- 2016-10-24
Related products to: DIRAS1 Blocking Peptide
Related articles to: DIRAS1 Blocking Peptide
- Colorectal cancer (CRC) is a prevalent global malignancy with particularly challenging treatment outcomes in advanced stages. Oxaliplatin (OXA) is a frontline chemotherapeutic agent for CRC. However, 15% to 50% of stage III patients experience recurrence due to drug resistance. Elucidating the molecular mechanisms underlying OXA resistance is, therefore, crucial for improving CRC prognosis. The role of DIRAS1, a RAS superfamily member with reported tumor-suppressive functions in various cancers, remains poorly defined in CRC. - Source: PubMed
Publication date: 2025/07/05
Long MinOuyang QianWen JingyiZeng XuanXu ZihuiZhong ShangweiHuang ChanghaoLuo Jun-Li - In a systematic explorative study of genetic patterns on chromosome 19, we discovered a pattern comprising 23 SNP alleles that is significantly associated with late-onset Alzheimer's disease (AD). This association was validated using two independent datasets. The pattern includes (), which has a long and disputatious relationship with AD. It also spans () and () and is upstream from (). We utilized population data to observe the frequencies of this genetic pattern for 11 different ancestries and noted that it is highly common for Europeans and relatively infrequent for Africans. This research provides a distinct genetic signature for AD risk, as well as insights into the complicated relationship between this disease and . - Source: PubMed
Publication date: 2025/02/26
Climer Sharlee - DIRAS family GTPase 1 (DIRAS1) has been reported as a potential tumor suppressor in other human cancer. However, its expression pattern and role in cervical cancer remain unknown. Knockdown of DIRAS1 significantly promoted the proliferation, growth, migration, and invasion of C33A and SiHa cells cultured . Overexpression of DIRAS1 significantly inhibited the viability and motility of C33A and SiHa cells. Compared with normal cervical tissues, DIRAS1 mRNA levels were significantly lower in cervical cancer tissues. DIRAS1 protein expression was also significantly reduced in cervical cancer tissues compared with para-cancerous tissues. In addition, DIRAS1 expression level in tumor tissues was significantly negatively correlated with the pathological grades of cervical cancer patients. DNA methylation inhibitor (5-Azacytidine) and histone deacetylation inhibitor (SAHA) resulted in a significant increase in DIRAS1 mRNA levels in C33A and SiHa cells, but did not affect DIRAS1 protein levels. FTO inhibitor (FB23-2) significantly down-regulated intracellular DIRAS1 mRNA levels, but significantly up-regulated DIRAS1 protein levels. Moreover, the down-regulation of METTL3 and METTL14 expression significantly inhibited DIRAS1 protein expression, whereas the down-regulation of FTO and ALKBH5 expression significantly increased DIRAS1 protein expression. In conclusion, DIRAS1 exerts a significant anti-oncogenic function and its expression is significantly downregulated in cervical cancer cells. The m6A modification may be a key mechanism to regulate DIRAS1 mRNA stability and protein translation efficiency in cervical cancer. - Source: PubMed
Publication date: 2024/02/19
Wang Yu-YanYe Lian-HuaZhao An-QiGao Wei-RanDai NingYin YuZhang Xin - [This retracts the article DOI: 10.2147/CMAR.S332640.]. - Source: PubMed
Publication date: 2023/11/11
- Studies on DNA methylation (DNAm) in Alzheimer's disease (AD) have recently highlighted several genomic loci showing association with disease onset and progression. - Source: PubMed
Publication date: 2023/05/06
Sommerer YasmineDobricic ValerijaSchilling MarcelOhlei OlenaSabet Sanaz SedghpourWesse TanjaFuß JaninaFranzenburg SörenFranke AndreParkkinen LauraLill Christina MBertram Lars