Ask about this productRelated genes to: SLC16A6 Blocking Peptide
- Gene:
- SLC16A6 NIH gene
- Name:
- solute carrier family 16 member 6
- Previous symbol:
- -
- Synonyms:
- MCT6, MCT7
- Chromosome:
- 17q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-02-10
- Date modifiied:
- 2015-12-04
Related products to: SLC16A6 Blocking Peptide
Related articles to: SLC16A6 Blocking Peptide
- Ulcerative colitis (UC) is an immune-mediated chronic inflammatory bowel disease, and with the rising global incidence and the risk of malignant transformation, the treatment of UC is challenged by heterogeneous progression and limited targeted therapies, and its underlying pathogenesis remains unclear. This study aims to identify novel therapeutic targets for UC, elucidate the genetic factors associated with UC development, and advance precision medicine strategies for UC. - Source: PubMed
Publication date: 2025/12/08
Zhu XiangYang YujieZhu Yi - Evidence for the microbiome's role in human health and disease has been piling up ever since the human microbiome project. The composition of one's microbiome can have a major effect on one's risk of developing cancer and the nature of how cancer develops. Several estimates suggest the percentage of cancer cases that can be attributed to microorganisms at around 15%. In addition, researchers are still trying to figure out how the microbiota, and the gut microbiota in particular, affects how a patient responds to chemotherapy, immunotherapy, and radiotherapy. In this light, we conducted an in-depth bioinformatics analysis of the gut microbiota- RCCstem cells axis, utilizing python-based programme and enrichment databases to analyses data from many sources, including clinical data, transcription factors, kinases and gene expression profile of RCCstem cells. Five genes, including SLC16A6, CPNE5, AFAP1L1, SCARF1, and NOTCH4, were shown to be shared by the hub gut microbiota and extracellular proteins. Patients with RCCstem cells had a disproportionately high number of certain types of bacteria. In patients expression profile have high CPNE5, AFAP1L1, SCARF1, and NOTCH4 expression. RCCsurvival rates are reduced by roughly 50% due to all of the genes involved. Also, the Actinobacteria and Gammaproteobacteria possible role in renal cancer development via relation to cancer stem cells. The gut microbiota and its components were considered for their possible relevance in the development of RCC. - Source: PubMed
Publication date: 2025/12/09
Alimoradi EhsanHashemnejad Mohammad AminEtemad SarehArabi MaryamBereimipour Ahmad - Acute myeloid leukemia (AML) is a heterogeneous disorder marked by irregular expansion and maturation, giving rise to the aggregation of immature myeloid precursor cells. Although most patients achieve remission with initial treatment, the majority of relapses lead to poorer overall survival. The bone marrow (BM) immune microenvironment has been proven to significantly affect the progression of AML. However, the mechanisms that cause the imbalance of immune cell subsets and phenotypes remain partially obscure. Therefore, this research sought to explore the immune-regulatory genes and to determine their role in AML. - Source: PubMed
Publication date: 2025/09/16
Pan YueyuanWu GuocaiLiu ChenchenChen MingguiXia TianMa YonghuaYang ZhigangWen Ruiting - Neoadjuvant chemoradiotherapy (nCRT) is essential for treating locally advanced rectal cancer (LARC), however response to nCRT varies, and reliable predictors are lacking. - Source: PubMed
Publication date: 2025/07/31
Peric JelenaDragicevic SandraMiladinov MarkoRom Aleksandra DjikicBjelanovic JasnaKovac JelenaDespotovic JovanaBabic TamaraLjubicic JelenaPavlovic DunjaStojkovic Jovana RosicDimitrijevic IvanBarisic GoranMarkovic VelimirNikolic Aleksandra - Selecting animals to reduce their environmental impact is important for implementing sustainable livestock production systems. Identifying genes influencing water consumption and general activity in grazing beef cattle can aid in selecting efficient animals. This work aimed to verify the differential gene expression (DE) and dispersion (DD) profiles associated with water consumption frequency (WCF) and general activity (GA) in grazing Nelore and F1 (Nelore × Angus) cattle. Behavioral data were collected from 36 to 33 Nelore and F1 animals, respectively, for 12 h daily over four days. For the RNA sequencing, ten animals (five with higher frequency and five with lower frequency) were selected for WCF and GA in each breed. The functional and enrichment analyses revealed that the genes found in the WCF animals were associated with glucose metabolism (LOC520336 and GCNT2), kidney physiology (ATP6V0A4), the immune system (CD96 and KLRD1), adaptive capacity, fat deposition (THBS1), and blood pressure maintenance (CDCA7). The genes influencing GA were associated with adaptation to environmental temperature and challenging conditions (SLC16A6, STOM, CLTA and IFNAR2). More pronounced changes and functional enrichments was observed in Nelore cattle, particularly for WCF. F1 cattle showed more differential dispersion genes related to general activity, suggesting variability in gene expression might be more relevant for this trait in the crossbred animals. In conclusion, the genes identified in this study were associated with several important traits related to the adaptive capacity of animals. These genes can elucidate and help select animals that are more adapted to challenging environments and reduce their environmental impact, leading to a more sustainable livestock production system. - Source: PubMed
Publication date: 2025/07/21
Watanabe Rafael NakamuraBernardes Priscila ArrigucciBerça Andressa ScholzFonseca Natalia Vilas BoasCunha Samla Marques FreireRodrigues Julia LisboaBuzanskas Marcos EliCardoso Tainã FigueiredoFaro Lenira ElReis Ricardo AndradeCoutinho Luiz LehmannRegitano Luciana Correia de AlmeidaMunari Danísio Prado