Ask about this productRelated genes to: OR2J2 Blocking Peptide
- Gene:
- OR2J2 NIH gene
- Name:
- olfactory receptor family 2 subfamily J member 2
- Previous symbol:
- -
- Synonyms:
- OR6-8, hs6M1-6, dJ80I19.4
- Chromosome:
- 6p22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-09
- Date modifiied:
- 2016-10-05
Related products to: OR2J2 Blocking Peptide
Related articles to: OR2J2 Blocking Peptide
- Chronic kidney disease (CKD) and chronic obstructive pulmonary disease (COPD) frequently present as comorbid conditions, while the underlying mechanisms remain largely unknown. Therefore, we aimed to explore the genetic correlations, shared genetic variants, and potential causal relationships between five kidney function traits (serum creatinine-based estimated glomerular filtration rate (eGFRcrea), cystatin C-based estimated glomerular filtration rate (eGFRcys), blood urea nitrogen (BUN), urinary albumin-to-creatinine ratio (UACR), urate) and four lung function traits (forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), FEV1/FVC ratio (RATIO), and peak expiratory flow (PEF)), using data from UK Biobank and CKDGen Consortium with a total of about 1 004 040 participants. Our genome-wide cross-trait study found a strong genetic correlation between eGFRcys, urate, and FVC, and causal analysis using summary effect estimates further confirmed a negative causal effect of FVC on urate while identifying a positive causal effect of eGFRcrea on the RATIO. Cross-trait analysis uncovered 6 overlapped genes significantly shared across 20 trait pairs. Another 7 key genes were further found via transcriptome-wide association, colocalization, and fine-mapping analyses. These 13 key genes converged on four major biological functions, including immune response, endogenous compounds, developmental regulation, and olfactory receptors. Notably, six genes: RF00017, ZNF391, CYP1A1, CYP1A2, OR2J2, and OR14J1, showed novel links to both kidney and lung function traits. These findings uncover the genetic basis of kidney-lung interorgan communication and identify potential therapeutic strategies for reducing multi-system comorbidity. - Source: PubMed
Su ShiqiXiang NanyanYao PeijiYang YongSu ShuFu TingtingWang LeLiao ShuyuanLi WeiminLin YifeiHuang Jin - The development of black tea quality is the outcome of the synergistic interaction between tea cultivars and the ecological environment of the production area, including factors such as climate, soil, and cultivation practices. Nevertheless, within a specific geographical region, systematic analysis of the environmental regulation mechanisms governing processing adaptability and quality formation among different cultivars remains insufficient. This study evaluated six Camellia sinensis cultivars from the Jingshan region of Hangzhou, China, integrating non-targeted metabolomics, sensory profiling, bioassays, and molecular docking to elucidate cultivar-specific quality attributes. Non-volatile metabolomics identified 84 metabolites linked to color and taste, including amino acids, catechins, flavonoid glycosides, and phenolic acids. Sensory and metabolite correlations revealed that amino acids enhanced brightness and imparted fresh-sweet flavors, while catechins contributed to bitterness and astringency. Specific metabolites, such as 4-hydroxybenzoyl glucose and feruloyl quinic acid, modulated color luminance. Volatile analysis identified 13 aroma-active compounds (OAV ≥ 1), with 1-octen-3-ol, phenylacetaldehyde, and linalool endowing JK with distinct floral-fruity notes. Molecular docking further demonstrated interactions between these volatiles and olfactory receptors (e.g., OR1A1 and OR2J2), providing mechanistic insights into aroma perception. These findings establish a robust link between cultivar-driven metabolic profiles in black tea, offering actionable criteria for cultivar selection and quality optimization in regional tea production. - Source: PubMed
Publication date: 2025/04/29
Wu RuiLiang HuilingHu NanLu JiajiaLi ChunfangTang Desong - Chemosensory impairment is an outstanding symptom of SARS-CoV-2 infections. We hypothesized that measured sensory impairments are accompanied by transcriptomic changes in the foliate papillae area of the tongue. Hospital personnel with known SARS-CoV-2 immunoglobulin G (IgG) status completed questionnaires on sensory perception (n = 158). A subcohort of n = 141 participated in forced choice taste tests, and n = 43 participants consented to donate tongue swabs of the foliate papillae area for whole transcriptome analysis. The study included four groups of participants differing in IgG levels (≥ 10 AU/mL = IgG; < 10 AU/mL = IgG) and self-reported sensory impairment (SSI). IgG subjects not detecting metallic taste had higher IgG levels than IgG participants detecting iron gluconate (p = 0.03). Smell perception was the most impaired biological process in the transcriptome data from IgG/SSI participants subjected to gene ontology enrichment. IgG/SSI subjects demonstrated lower expression levels of 166 olfactory receptors (OR) and 9 taste associated receptors (TAS) of which OR1A2, OR2J2, OR1A1, OR5K1 and OR1G1, as well as TAS2R7 are linked to metallic perception. The question raised by this study is whether odorant receptors on the tongue (i) might play a role in metal sensation, and (ii) are potential targets for virus-initiated sensory impairments, which needs to be investigated in future functional studies. - Source: PubMed
Publication date: 2024/07/04
Danzer BarbaraJukic MateoDunkel AndreasAndersen GabyLieder BarbaraSchaudy ErikaStadlmayr SarahLietard JoryMichel TimmKrautwurst DietmarHaller BernhardKnolle PercySomoza MarkLingor PaulSomoza Veronika - Molecular mechanisms of caramel-like odorant-olfactory receptor interactions were investigated based on molecular docking and molecular dynamics simulations. The transmembrane regions TM-3, TM-5 and TM-6 of receptors were main contributors of amino acid residues in the docking. Molecular docking results showed that hydrogen bonding and pi-pi stacking were the key forces for the stabilization of caramel-like odorants. The binding energies were positively correlated with the molecular weight of caramel-like odorants. Residues Asn155 (84%, OR2W1), Asn206 (86%, OR8D1), Ser155 (77%, OR8D1), Asp179 (87%, OR5M3), Val182 (84%, OR2J2) and Tyr260 (94%, OR2J2) with high frequencies played an important role in the complexes formation. Odorants 4-hydroxy-5-methylfuran-3(2H)-one (16#) and methylglyoxal (128#) were screened by molecular field-based similarity analysis, which tended to bind to the receptors OR1G1 and OR52H1 respectively, resulting a caramel-like aroma perception. The obtained results are useful for better understanding the perception of caramel-like odorants and their high-throughput screening. - Source: PubMed
Publication date: 2023/05/29
Zeng ShitongZhang LiliLi PengPu DandanFu YingjieZheng RuiyiXi HuiQiao KainaWang DingzhongSun BaoguoSun ShihaoZhang Yuyu - Low-grade myofibroblastic sarcoma (LGMS) is a rare, poorly differentiated, malignant tumor. The disease mainly occurs in the head and neck and rarely metastasizes at any age. Currently, there is no consensus regarding the treatment of metastatic LGMS. Here, we report the case of a 45-year-old man who was admitted to our hospital with cough for two weeks and abdominal pain for one week. Preoperative computed tomography revealed a large mass (116×35 mm) in both the lungs and jejunal mass (maximum diameter, 32 mm). The tumor was excised, and immunohistochemical staining was positive for SMA and CD117 and negative for desmin and CD34, indicating a case of LGMS. The patient was effectively treated with apatinib (250 mg/day) after failure of imatinib, liposomal doxorubicin, and ifosfamide. The progression-free survival time was 8.5 months, and the overall survival time was 17 months after treatment with apatinib. No grade 3 or 4 side effects were observed, except hand-foot syndrome. Whole-exome sequencing (WES) and RNA sequencing (RNA-seq) were performed on the patient's jejunal tumor and para-cancerous tissue samples, and bioinformatics analysis was performed on the results. WES identified five mutations in MKI67, OR2J2, EPPK1, FCGBP, and OR10G4. RNA-seq revealed that 1422 genes were upregulated and 1890 genes were downregulated. The differentially expressed genes were mainly enriched in the phosphatidylinositol 3-kinase (PI3K) signaling pathway, neuroactive ligand-receptor interaction signaling pathway, and cAMP signaling pathway. Our study indicated that apatinib may be a potential novel and effective treatment for LGMS. - Source: PubMed
Publication date: 2022/06/07
Lin YanGao XingLiu ZiyuLiu ZhihuiLi YongqiangLiang RongLiao ZhilingYe Jiazhou