GALNTL4 Blocking Peptide
- Known as:
- GALNTL4 Blocking Peptide
- Catalog number:
- 33r-3993
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- GALNTL4 Blocking Peptide
Related genes to: GALNTL4 Blocking Peptide
- Gene:
- GALNT18 NIH gene
- Name:
- polypeptide N-acetylgalactosaminyltransferase 18
- Previous symbol:
- GALNTL4
- Synonyms:
- MGC71806, GALNT15, GalNAc-T18
- Chromosome:
- 11p15.4
- Locus Type:
- gene with protein product
- Date approved:
- 2004-07-21
- Date modifiied:
- 2016-10-05
Related products to: GALNTL4 Blocking Peptide
Related articles to: GALNTL4 Blocking Peptide
- Excessive dieting (ED), a common weight-control strategy, often causes neurological and emotional disturbances, yet its gut-brain interaction mechanisms remain unclear. Employing a short-term dietary (SDR) adult male rabbit model, we found that SDR can induced cerebral cortex up-regulation of the immune-related genes (e.g., C1QC, SAA3) enriched in NF-kappa B signaling pathways, contrasted with down-regulation of sex hormone-related genes (e.g., PRLR, SPA17) implicated in metabolic homeostasis. Furthermore, dysregulated expression of metabolic genes (e.g., PPM1J, GALNT18) in the cecum of the SDR group interacted to impair the immune protection pathways related to intestinal mucosa. Then, SDR significantly increased the cecal Firmicutes/Bacteroidetes ratio (from 3.38 to 5.57) and reduced microbial diversity. Specifically, beneficial bacteria involved in tryptophan metabolism and neurotransmitter synthesis (e.g., Bacteroidales_bacterium, Alistipes_indistinctus) decreased, whereas bile acid-metabolizing bacteria (e.g., Clostridium_sp._CAG:710, Ruminococcus_sp._Marseille-P6503) linked to increase energy metabolism. The top 20 genes from the brain-gut axis analysis (e.g., ITPR1, CAMK4, CDK5R1) were enriched in critical neural pathways like axon guidance, GABAergic synapse, and long-term potentiation. Notably, key neurodevelopmental genes (e.g., GPR37, GPX3) correlated with these microbial shifts, implicating oxidative stress, synaptic plasticity, and mitochondrial function in microbiota-host crosstalk. This study highlights a "microbial-metabolism-neural" axis in SDR, providing novel targets for future obesity intervention strategies. - Source: PubMed
Publication date: 2025/12/08
Li YanhongChen JianningQi XiaolanHe YanWang GuozeWei LiminHong Wei - Population studies elucidating the genetic architecture of early menopause have mainly focused on European ancestries, leaving a gap in understanding of the genetic influences in non-European populations. This study seeks to identify potential genetic variants linked to early menopause in Iranian women. - Source: PubMed
Publication date: 2025/08/15
Najd-Hassan-Bonab LeilaMotafeghi FarzanehMoazzam-Jazi MaryamFarahmand MaryamAzizi FereidoonDaneshpour Maryam SRamezani Tehrani Fahimeh - Nonalcoholic steatohepatitis-associated hepatocellular carcinoma (NASH-HCC) is an increasing global health issue. Research indicates that amyloid precursor protein (APP) might be a diagnostic marker and therapeutic target for HCC. However, the specific role of O-glycosylation of APP in NASH-HCC remains unclear. A NASH-HCC mice model was established by feeding BALB/c inbred mice with a high-fat/high-cholesterol (HFHC) diet and injection of CCl. Hematoxylin-Eosin (HE) and Oil Red O (ORO) staining of liver tissue were then carried out to evaluate the progression of NASH-HCC. Immunohistochemistry (IHC) and Western blot were utilized to analyze APP levels. Immunoprecipitation (IP) was used to analyze the O-GalNAc modification of APP, and co-immunoprecipitation (Co-IP) and immunofluorescence were used to assess the Polypeptide N-Acetylgalactosaminyltransferase 18 (GALNT18) binding level of APP. Moreover, cell experiments confirmed the functional role of APP in HCC. APP was studied in vivo using an animal model. An up-regulation of APP and its O-glycosylation modification in patient-derived NASH-HCC tissues, animal models, and HCC cell lines was observed. The typical malignant phenotype of HCC, such as proliferation, migration, and invasion, was significantly suppressed by the knockdown of APP and was then partially rescued by the addition of UDP-GalNAc, a glycosylation activator. We demonstrated that GALNT18 interacted with APP in NASH-HCC models and upregulated its O-glycosylation. APP was finally shown to activate the EGR1/TGF-β1/Smad signaling, thereby driving the oncogenic progression of HCC. In vitro, APP knockdown inhibited NASH-HCC progression. This study identifies GALNT18-mediated O-glycosylation of APP as crucial in NASH-HCC development via the EGR1/TGF-β1/Smad pathway, suggesting that targeting GALNT18-APP signaling could be a therapeutic approach against NASH-HCC. - Source: PubMed
Publication date: 2025/08/15
Chen DanNie YingShi LiZhong DingfuWu JiajiaJin BeiLiu Dong - The current study aims to investigate the potential interaction between glycosylation profiles of the Ningxiang breed (NX) and Western Duroc × Landrace × Yorkshire breed (DLY) weaned piglets, and their characteristic microbes, employing integrated analyses of transcriptomics and metagenomics. Twenty-four (12 NX and 12 DLY) at 28 days of age were transported into an experimental house and fed the same weaned piglet diet. The trail period was 7 days. Results revealed that the NX piglets had a higher growth-to-feed ratio, body weight gain scale, and lower pathological score of intestinal injury compared with the DLY piglets ( < 0.01). DLY piglets displayed elevated mRNA expression levels of and in colonic mucosal tissue than NX piglets ( < 0.05). Within the O-linked glycosylated differentially expressed genes (DEGs), , , , , and were significantly upregulated in DLY piglets relative to NX piglets ( < 0.05). Conversely, , , , and were significantly downregulated in DLY piglets compared to NX piglets ( < 0.05). The gene was hardly expressed in the transcriptome of DLY piglets. At the phylum taxonomic level, NX piglets had a higher abundance of Firmicutes, while DLY piglets had a higher abundance of Proteobacteria. At the genus taxonomic level, NX piglets had a higher abundance of , whereas DLY piglets had a higher abundance of , and . The results of the correlation between intestinal differential bacteria and O-chain glycosylated DEG showed that , and were associated with showed a positive correlation ( = 0.67). Through comparative analysis of differentially glycosylated genes and their associated functions, this study highlights the potential role of reduced expression of and genes, involved in O-linked protein and glycan reactions, in impairing the intestinal barrier function of DLY piglets. Furthermore, members of the and genera may actively contribute to the regulation of piglet colon glycosylation profiles. - Source: PubMed
Publication date: 2024/12/10
Cheng HaoLi HaoZhao YujieYang KaiWang JingTan BieMa Xiaokang - To examine the associations of single-nucleotide polymorphisms (SNPs) within interleukin-6 (IL6) and IL-6 receptor (IL6R) as well as several potential SNPs revealed in a genome-wide association study (GWAS) with clinical response to tocilizumab (TCZ) in Chinese rheumatoid arthritis (RA) patients. - Source: PubMed
Publication date: 2024/12/22
Qin WenWang Meng-QiaoWang Ting-HuiXiao Dong-MeiWu Xiu-DiCen Han