Ask about this productRelated genes to: INPP5B Blocking Peptide
- Gene:
- INPP5B NIH gene
- Name:
- inositol polyphosphate-5-phosphatase B
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1p34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-10-14
- Date modifiied:
- 2016-10-05
Related products to: INPP5B Blocking Peptide
Related articles to: INPP5B Blocking Peptide
- Migraine (MIG) frequently co-occurs with autoimmune diseases (ADs), but the shared genetic basis underlying this comorbidity remains unclear. - Source: PubMed
Publication date: 2026/05/03
Chen JunWu YameiLiu MeijunFan YihuaCao TianZhao LiangbinLong KunlanWang CixiaoWu LingLv LizeyuLi HaijunChen XingyueZhi LijiaHe YuchiTao Tian - Hepatic steatosis is a hallmark of alcohol-associated liver disease (ALD) and interacts with hepatic inflammation to drive disease progression. NF-κB-inducing kinase (NIK) has been established as a bridge linking inflammation to steatosis in ALD. Intriguingly, while hepatocyte-specific NIK deficiency attenuated ALD in the chronic-plus-binge model, it paradoxically exacerbated the disease under chronic ethanol exposure, suggesting a complex, context-dependent role for NIK. - Source: PubMed
Publication date: 2025/12/12
Zhang WenQi ManzhiZhao XiaojingZhong YingXu WeilongSheng LiangYang Liu - Genome-wide association studies have identified over 300 genomic loci associated with coronary artery disease (CAD) risk, but identifying functional variants remains challenging due to linkage disequilibrium. Here we show a comprehensive functional characterization of CAD-associated variants in primary vascular smooth muscle cells (SMCs). We performed lentivirus-based massively parallel reporter assays (lentiMPRAs) on 25,892 CAD-associated variants, testing their allele-specific enhancer activity in quiescent and proliferative SMCs. We identified 122 candidate variants with enhancer activity and allelic imbalance, including 23 variants showing condition-biased and 41 showing sex-biased effects. Integrating lentiMPRA with CUT&RUN epigenome profiling and expression quantitative trait loci data, we prioritized 49 functionally relevant variants. CRISPRi experiments on eight variants confirmed their regulatory effects on nine variant-gene pairs: rs35976034 (MAP1S), rs4888409 (CFDP1), rs73193808 (MAP3K7CL), rs67631072 (INPP5B/FHL3), rs1651285 (SNHG18), rs17293632 (SMAD3), rs2238792 (ARVCF) and rs4627080 (NRIP3). Our results fine-map the causal variants that confer CAD risk through their effects on vascular SMCs. - Source: PubMed
Publication date: 2025/10/07
Barbera NicolasLei LilyWallace AlexiaErin FarukPerry R Noahden Ruijter Hester MCivelek Mete - To elucidate the role of miRNAs in porcine muscle tissues, this study used Solexa high-throughput sequencing to identify and compare differentially expressed miRNAs in Landrace pigs and the Diannan small ear pigs. - Source: PubMed
Publication date: 2025/07/23
Xie YuxiaoCheng WenjieHao MeilinYi Lan-LanZhu Jun-HongZhao Yan-GuangZhao Sumei - Inositol-(1,4,5)-trisphosphate (Ins(1,4,5)P) is a crucial secondary messenger that controls calcium (Ca) levels inside cells, yet many questions regarding Ins(1,4,5)P metabolism are challenging to address with current methods. Here, a semi-enzymatic milligram scale synthesis of isotopically labeled [C]Ins(1,4,5)P is reported which then served as a substrate to monitor the activity of mammalian type II inositol 1,4,5-trisphosphate 5-phosphatase INPP5B, using NMR spectroscopy in real time. In addition, the phosphorylation sequence catalyzed by inositol polyphosphate multikinase IPMK was confirmed using [C]Ins(1,4,5)P and 2D NMR spectroscopy. The method was subsequently applied to characterize the phosphorylation/dephosphorylation reactions of a putative inositol phosphate kinase from the alga (IPK2). IPK2 displayed 6-kinase activity towards [C]Ins(1,4,5)P, and dual 4/6- and 5-phosphatase activity towards [C]Ins(1,3,4,5,6)P. Finally, [C]Ins(1,4,5)P was utilized as an internal standard in hydrophilic liquid interaction chromatography mass spectrometry (HILIC-MS) experiments, to quantify dephosphorylation of Ins(1,4,5)P by INPP5B. [C]Ins(1,4,5)P therefore constitutes a broadly applicable analytical tool that should facilitate the characterization of Ins(1,4,5)P metabolism in the future. - Source: PubMed
Publication date: 2025/07/23
Patharkar AtharvaAmma MeikeIsern JaimeChaudron ZoéBesson-Bard AngéliqueNicolas-Francès ValérieRosnoblet ClaireWendehenne DavidSchmieder PeterFiedler Dorothea