C21orf66 Blocking Peptide
- Known as:
- C21orf66 Blocking Peptide
- Catalog number:
- 33r-3967
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- C21orf66 Blocking Peptide
Related genes to: C21orf66 Blocking Peptide
- Gene:
- PAXBP1 NIH gene
- Name:
- PAX3 and PAX7 binding protein 1
- Previous symbol:
- C21orf66, GCFC1
- Synonyms:
- GCFC, fSAP105
- Chromosome:
- 21q22.11
- Locus Type:
- gene with protein product
- Date approved:
- 2001-07-27
- Date modifiied:
- 2015-08-25
Related products to: C21orf66 Blocking Peptide
Related articles to: C21orf66 Blocking Peptide
- Yaks are important livestock in high-altitude regions, and their polled trait can effectively improve breeding and management efficiency. In this study, whole-genome resequencing combined with a GWAS was employed to identify a significantly associated region of approximately 273.6 kb on chromosome 1 (36,313,286-36,586,879 bp) in Xueduo yaks. This region contains 1001 significant single-nucleotide polymorphism (SNP) loci and is located within a long intergenic non-coding RNA (lincRNA) region. Candidate genes , and adjacent to this region were identified. Among these, the gene plays a crucial role in neural crest development, suggesting that it may be a core gene regulating horn development in yaks. Further analysis of Ashdan yaks (a polled breed developed from Datong yaks) indicated that the two breeds share the same candidate genes and a subset of associated genetic variants for the polled trait, suggesting a degree of genetic conservation underlying this trait across yak breeds. This study provides a theoretical basis for polled yak breeding. - Source: PubMed
Publication date: 2026/02/14
Zhong ChuangWang ZiyingLiu ShujieZhang ZhianCui Zhanhong - - Source: PubMed
Publication date: 2025/05/19
Huang CongLi WentingZhao ShizhengZhang WeiYu Bo - The mammalian epidermis is a structurally complex tissue that serves critical barrier functions, safeguarding the organism from the external milieu. The development of the epidermis is governed by sophisticated regulatory processes. However, the precise mechanism maintaining epidermal homeostasis remains incompletely elucidated. Recent studies have identified Paxbp1, an evolutionarily conserved protein, as being involved in the developmental regulation of various cells, tissues, and organs. Nonetheless, its role in skin development has not been explored. In this study, we report that the targeted deletion of Paxbp1 in epidermal keratinocytes mediated by keratin 14-Cre leads to severe disruption in skin architecture. Mice deficient in Paxbp1 exhibited a substantially reduced epidermal thickness and pronounced separation at the dermal-epidermal junction upon birth. Mechanistically, we demonstrate that the absence of Paxbp1 hinders cellular proliferation, marked by a halt in cell cycle transition, suppressed gene expression of proliferation, and a compromised DNA replication pathway in basal keratinocytes, resulting in the thinning of the skin epidermis. Moreover, molecules and pathways associated with hemidesmosome assembly were impaired in Paxbp1-deficient keratinocytes, culminating in the detachment of the skin epidermal layer. Therefore, our study highlights an indispensable role of Paxbp1 in the maintenance of epidermal homeostasis. - Source: PubMed
Publication date: 2024/09/03
Huang CongLiu ShenglinLi WentingZhao ShizhengRen XuanyaoZhuo FanZhang KaoyuanLi XiahongWu JingwenZhu ZimoChen ChaoZhang WeiYu Bo - This computational analysis investigated sequence complementarities between the gene and human noncoding (nc)RNAs and characterized their interactions in the context of paraneoplastic dermatomyositis. - Source: PubMed
Publication date: 2024/06/13
Talotta Rossella - The size and condition of the peripheral CD4 T cell population determine the capacity of the immune response. Under homeostatic conditions, the size of the peripheral CD4 T cell population is maintained through turnover and survival. However, the underlying mechanisms remain inadequately understood. Here, we observed a significant decrease in the percentage of CD4 T cells in the periphery following the targeted deletion of the Paxbp1 gene in mouse T cells. In the absence of Paxbp1, naïve CD4 T cells displayed reduced surface interleukin-7 receptor levels and a decreased capacity to respond to survival signals mediated by interleukin-7. In addition, naïve CD4 T cells deficient in Paxbp1 demonstrated impaired T cell antigen receptor signalling, compromised cell cycle entry, decreased proliferation, and increased apoptosis following stimulation, all of which contributed to the reduction in the number of peripheral CD4 T cells. Therefore, our study highlights the indispensable role of Paxbp1 in maintaining peripheral CD4 T cell homeostasis. - Source: PubMed
Publication date: 2024/05/15
Li WentingYang YangZhuo FanLiu ShenglinZhang KaoyuanZhang WeiHuang CongYu Bo