Ask about this productRelated genes to: PARN Blocking Peptide
- Gene:
- PARN NIH gene
- Name:
- poly(A)-specific ribonuclease
- Previous symbol:
- -
- Synonyms:
- DAN
- Chromosome:
- 16p13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-23
- Date modifiied:
- 2019-04-23
Related products to: PARN Blocking Peptide
Related articles to: PARN Blocking Peptide
- Class Switch Recombination (CSR) is essential for generating high-affinity antibody isotypes from IgM during adaptive humoral responses. Despite well-established roles for various transcription factors, whether CSR is subject to dedicated post-transcriptional control represents a significant gap in knowledge. By integrating conditional knockout models with SLE disease contexts, this study is the first to identify that the RNA-binding protein, poly(A)-specific ribonuclease (PARN), serves as a key positive regulator of antibody-secreting cell function. Mechanistically, PARN preferentially binds 3' UTRs and enhances the utilization of proximal poly(A) sites on a genome-wide scale in vivo. Further results show that PARN binds UGUA and AA(U/A)AAA upstream elements to form a specific spatial RNA-protein complex, through which it exerts exonuclease activity to shorten poly(A) tails, thereby decreasing mRNA stability. In addition, we identified a class of functional genes-including Foxp1-whose dynamic 3' UTR changes directly regulate antibody secretion. This study reports a novel post-transcriptional mechanism by which PARN promotes antibody production through modulation of 3' UTR length. These findings not only advance our understanding of humoral immune regulation but also highlight a potential therapeutic target for autoimmune diseases such as SLE. - Source: PubMed
Publication date: 2026/05/12
Sun SiyuanYang ChenWang XiaoyuHu NaijingZhang ShengyaoLi XinchunChen YuZhai JiananTang XiangfengLu WeiLu ChenxuCao ChangchangYu WeiruWu WenhaoNie XiaonanWang FengchaoFang BingRen FazhengLi YixuanChen Juan - Soil eukaryotes, including fungi, protists, plants, and animals, are central to biosphere functioning and resilience. The Global Standardised Soil Eukaryome Dataset (GloSED) is the first dataset encompassing the entire spectrum of soil eukaryotes, covering 4,063 sampling sites in 121 countries on all continents, revealing nearly one million operational taxonomic units. All samples were collected and analysed using a standardised protocol minimizing technical biases. Long-read sequencing of full-length ITS and 18S-V9 regions provide broad taxonomic coverage and high-resolution identification supported by specialist curation of "dark taxa". A rigorous bioinformatic processing ensures against homopolymer errors, PCR-mediated chimeras, and index switching providing high data quality. The dataset is supported by raw sequences and an open-source containerised workflow for reproducible analyses. The samples are accompanied by land-cover description and directly measured soil pH, δC, δN, as well as P, K, Ca, Mg, and total C and N contents. GloSED is the first database that enables ecological and biogeographic studies of entire soil eukaryotic communities from local to global scales. - Source: PubMed
Publication date: 2026/05/05
Mikryukov VladimirDulya OlesyaAbarenkov KessyAnslan StenHagh-Doust NiloufarPrins VictoriaPanksep KristelPõlme SergeiIbrahim Khalid SBahram MoAdamson KalevAgan AhtoAhmed TalaatAlatalo Juha MAlbornoz Felipe EAl-Hatmi Abdullah MsAlkahtani SaadAlvarez-Manjarrez JulietaAnkuda JelenaAntonelli AlexandreAriyan ManikandanArmolaitis KęstutisAslani FarzadBarrio Isabel CBauters MarijnBiersma Elisabeth MachteldBitenieks KrišsBonito GregoryBrearley Francis QBråthen Kari AnneBuegger FranzButterbach-Bahl KlausBálint MiklósCameron Erin KCanini FabianaCasique-Valdés RebecaCorrales AdrianaDavydov Evgeny ADe Crop EskeDe Kesel AndréDjeugap Joseph FovoDrenkhan ReinDuarte Ritter CamilaDudov Sergey VEspenberg MikkFanuel OnguaFedosov Vladimir EFlorence LukeFurneaux Brendan RFurtado Ariadne N MFärkkilä SanniGamova Natalia SGaribay-Orijel RobertoGeml JózsefGhosh SoumyaGodoy RobertoGohar DaniyalGryzenhout MariekaHasan Ayad HHashem Amr HHeilmann-Clausen JacobHenkel Terry WHiiesalu IndrekHiiesalu IngaHosseyni Moghaddam Mahdieh SHyde Kevin DInostroza KarinaKariman KhalilKarimullina ElinaKepfer-Rojas SebastianKhalid Abdul NasirKlavina DartaKohout PetrKorotkov Yuri NKupagme John YKurina OlaviLamit Louis JamesLateef Adebola AzeezLedoux Njouonkou AndréLim Young WoonMaciá-Vicente Jose GMakovskis KristapsMartínez SebastiánMarín CésarMeidl PeterMortimer Peter EMundra SunilNaluyange VictoriaNetherway TarquinNewsham Kevin KNouhra EduardoNyamukondiwa CasperNteziryayo VincentOchieno Dennis M WOja JaneOnipchenko Vladimir GOtsing EveliOwaid Mustafa NadhimPiepenbring MeikePochekutova PolinaPombo Maihyra MarinaPritsch KarinPuusepp RasmusPärn JaanPõldmaa KadriRahimlou SalehRinaldi Andrea CRojas OscarRoslin TomasRunnel KadriRähn ElisabethSaba MalkaSaitta AlessandroSalih Talal SabhanSarapuu JoosepSerrano EduardSerrano OscarSharmah DiponSharp CathySkalska-Tuomi Maria WTchan Kassim IssifouTruong Camillevan der Merwe HelgaVanié-Léabo Linda L PVasco-Palacios Aida MVerbeken AnnemiekeVlk LukášWijayawardene Nalin NWood Jennifer LYasanthika W A ErandiYorou Nourou SZahn GeoffreyZettur IrmaZucconi LauraKõljalg UrmasTedersoo Leho - Lumbar spinal stenosis (LSS) affects over 100 million people globally, with an increasing incidence due to an ageing population. While LSS is known to be heritable, its genetic basis remains poorly understood. We conduct a genome-wide meta-analysis of LSS in 40,303 cases and 741,469 controls. We identify 73 previously unreported loci in addition to 15 known loci, and highlight spinal degeneration as a key pathogenic mechanism. In 12,784 surgically treated cases, we discover five loci specifically associated with severe disease. Age-of-onset analyses show that most variants influence risk after midlife, but some confer susceptibility as early as age 34. Mendelian randomization further demonstrates causal effects of higher body mass and fat-free mass on LSS risk. Overall, our findings expand knowledge of the genetic background of LSS and inform future translational research. - Source: PubMed
Publication date: 2026/04/06
Salo VilleMäättä JuhaniTakala JasminHeikkilä Anni Reimann EneMägi Reedik Reis KadriElhanas Abdelrahman GReigo AnuPalta PriitEsko TõnuLeinonen VilleKarppinen JaroSliz EevaKettunen Johannes - Sulfate in glycans often serves as a determinant of glycan-protein interactions underlying mammalian physiology. Sulfated glycoconjugates in mammals encompass proteoglycans, glycoproteins, and glycolipids, and more than 30 sulfotransferases catalyze carbohydrate sulfation. - Source: PubMed
Publication date: 2026/03/21
Parn Kim WaiAngata Takashi - The majority of pri-miRNAs acquire a 5' cap and 3' poly(A) tail. Mature miRNAs recruit deadenylases that shorten poly(Α) tails triggering target mRNA degradation. Poly(A)-specific ribonuclease (PARN) is a deadenylase that also mediates late steps of noncoding RNA maturation. Herein, we show that PARN affects the expression of a subset of miRNAs in NCI-H520 cells of lung cancer origin, including miR-29a and miR-1207, which are also predicted to target PARN mRNA. PARN associates with pri-miR-29a and pri-miR-1207 regulating their poly(A) lengths. Conversely, miR-29a-3p and miR-1207-5p bind the 3' UTR of PARN mRNA and regulate its expression. Cleavage and polyadenylation specificity factor 6 (CPSF6) recruits PARN to pri-miRNAs and together they affect primary and mature miR-29a-3p levels. Modulation of PARN, miR-29a-3p, or miR-1207-5p expression affects cell migration. We present a model to describe the dynamic relation between PARN and miR-29a and discuss its biological significance. - Source: PubMed
Publication date: 2026/03/13
Kyritsis AthanasiosBeta Rafailia AaScutelnic DianaStravokefalou VasilikiDel Vescovo ValerioArsenopoulou Zoi VPapikinos KonstantinosGrasso MargheritaFontana FrancescaMoutopoulou ParaskeviTsiporis AlexandrosSamiotaki MartinaPanayotou GeorgeDenti Michela ABalatsos Nikolaos Aa