Ask about this productRelated genes to: PGM3 Blocking Peptide
- Gene:
- PGM3 NIH gene
- Name:
- phosphoglucomutase 3
- Previous symbol:
- -
- Synonyms:
- AGM1, DKFZP434B187, PAGM
- Chromosome:
- 6q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: PGM3 Blocking Peptide
Related articles to: PGM3 Blocking Peptide
- Per- and polyfluoroalkyl substances (PFAS) in atmospheric particulate matter remain poorly characterised at large spatial and temporal scales. This study investigated the spatiotemporal distribution, long-range transport and source contributions of both legacy and emerging PFAS in PM across eastern China. A total of 540 PM samples from ten cities in Zhejiang Province (2020-2023) were analysed. Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) trajectory modelling and positive matrix factorization (PMF) identified potential source regions and contributions. Total PFAS concentrations (∑PFAS) ranged from 9.1 to 12,264.6 pg/m, with a median of 64.9 pg/m. Perfluorooctanoic acid (PFOA) was the predominant PFAS (median 21.7 pg/m), whereas hexafluoropropylene oxide dimer acid (GenX) exhibited the highest median concentration (3.2 pg/m) among emerging PFAS. ∑PFAS levels in northeastern inland cities were higher in summer than in winter, likely due to southwesterly transport from a nearby fluorochemical industrial park. Seasonal variability in PFAS was also influenced by precursor oxidation, as evidenced by positive correlations between secondary organic carbon and selected perfluoroalkyl carboxylic acids. PMF analysis identified fluorochemical production as the dominant source in inland areas, while sea spray aerosol contributed substantially to coastal regions. Interannual trends showed declining legacy PFAS but increasing detection frequencies and concentrations of alternatives (e.g., GenX, 6:2 fluorotelomer sulphonate). Additional emerging PFAS were detected through suspect screening near the industrial area, indicating growing compositional complexity. Overall, these results emphasise the continued impact of fluorochemical industrial emissions on atmospheric PFAS and the ongoing transition in PFAS profiles from legacy to emerging compounds in particulate matter. - Source: PubMed
Publication date: 2026/04/15
Wu FeiDing HaoWu XiaodongWu LingyaoZhang YingyingLi YingShi YaliCai Yaqi - Per- and polyfluoroalkyl substances (PFAS) or "forever chemicals" have been increasingly detected in the atmosphere across urban, rural, and remote areas, raising the possibility of atmospheric exposure to humans. However, their exact emission sources to the atmosphere are poorly understood. Here, we investigated the atmospheric particulate matter (PM) associated emissions of restricted and new generation PFAS from the pre-treatment (grit chamber) and secondary settling steps of a wastewater treatment plant (WWTP). 12 PFAS including restricted perfluorooctanoic acid (PFOA) and perfluoroocatnesulfonic acid (PFOS), were detected in the PM samples. PFOS was the most abundant PFAS detected at all sampling points, with mean concentrations of 5.7 ± 1.7 pg/m, 0.42 ± 0.42 pg/m, and 0.60 ± 0.25 pg/m, in the grit-chamber, secondary settler, and staff building samples, respectively. The presence of PM bound PFOS and PFOA, which have been restricted for several years, raises concerns about their possible continued use and input into sewage systems. The complementary non-targeted analysis (NTA) of the grit-chamber samples and suspect screening of secondary settler and staff building samples revealed 14 additional tentatively identified organic compounds, including insecticides, metabolites, and industrial chemicals. Among these, 4-nitrophenol (confirmed with the authentic standard), a key brown carbon component linked to adverse health effects and cloud condensation activity, was detected in PM for the first time in both pre-treatment and secondary settling steps. These findings reveal a previously unrecognised source of atmospheric PFAS and 4-nitrophenol, with important implications for exposure and risk assessment. - Source: PubMed
Publication date: 2026/04/09
Kizhakkethil Jishnu PandamkulangaraBaglioli FelipeLeite Bárbara ZanicottiPossetti Gustavo Rafael CollereGodoi Ricardo H MKourtchev Ivan - Bladder cancer (BCa), a highly prevalent and aggressive tumor of the urinary system, typically exhibits poor clinical outcomes, particularly in advanced stages where therapeutic efficacy remains inadequate. A key characteristic of tumorigenesis, metabolic reprogramming, contributes substantially to cancer cell proliferation and metastatic progression. In the current investigation, phosphoglucomutase 3 (PGM3) was markedly overexpressed in BCa tissues, with elevated PGM3 expression strongly associated with unfavorable prognosis. Downregulation of PGM3 inhibited BCa tumor growth and metastasis by suppressing energy metabolism pathways, including glycolysis and oxidative phosphorylation (OXPHOS). Mechanistically, proteasome 26S subunit non-ATPase 11 (PSMD11) interacted with PGM3, reducing its ubiquitination and proteasomal degradation. Additionally, Parkin acted as a ubiquitinase, destabilizing PGM3, whereas PSMD11 competed with Parkin for PGM3 binding, thereby attenuating Parkin-mediated ubiquitination and stabilizing PGM3. Further analysis demonstrated that PSMD11 enhanced glycolysis and OXPHOS through PGM3, promoting BCa malignancy. Higher PSMD11 expression positively correlated with increased PGM3 expression. Collectively, these findings suggest that targeting the PSMD11/PGM3 axis could provide a promising therapeutic strategy for BCa. - Source: PubMed
Publication date: 2026/04/06
Cheng YuChen TaoZheng GuanghaoSong ZhenZhang GanXiao SongRao XuepengZeng Tao - As a part of Michigan's efforts to identify and address per- and polyfluoroalkyl substances (PFAS) contamination statewide, more knowledge of atmospheric PFAS concentrations is needed to better understand their atmospheric transport and impact on other environmental media. This research aimed to measure atmospheric concentrations of PFAS in Michigan's ambient air using low-cost and easy-to-use passive samplers and identify relationships with environmental factors. Passive samplers, consisting of polyurethane foam (PUF) discs and sorbent-filled polyethylene tubes (radiello-XAD samplers), were deployed for a month at 27 sites across Michigan and analyzed for both ionic and volatile, neutral PFAS. Short chain perfluorocarboxylic acids (PFCAs), specifically perfluoropropanoic acid (PFPrA) (d.f. 60 %) and perfluorobutanoic acid (PFBA) (d.f. 96 %), and perfluorooctane sulfonic acid (PFOS) (d.f. 63 %) were the most frequently detected compounds, with the ∑PFAS ranging from non-detect to 15.5 pg/m for the PUFs and from non-detect to 248 pg/m in the radiello-XAD samplers. 6:2 fluorotelomer alcohol was also frequently detected (d.f. 45 %) and had a positive correlation with both population density (r=.52, p<.05) and industrial sites' density (r=.48, p<.05). Detection of specific compounds on each type of sampler provided insight into the preferential transport pathway of atmospheric PFAS. For example, PFOS was observed mostly in the gas-phase, predominantly captured by the radiello-XAD samplers, while PFBA was mostly in the particle-phase, predominantly captured by the PUFs. This study highlights the importance of developing detection tools for measuring atmospheric PFAS across a vast geographic area to identify contributing factors to ambient concentrations. - Source: PubMed
Publication date: 2025/09/15
Woodward MelissaBecanova JitkaVojta SimonLohmann Rainer - Emission of polychlorinated dibenzodioxins and furans (PCDD/Fs) from municipal solid waste incineration (MSWI) poses a considerable public health risk, and characterization of PCDD/Fs' size distribution in flue gas is essential for understanding their formation, removal, atmospheric transport, and inhalation risks. Here, we conducted a detailed investigation on the gaseous and size-resolved PCDD/Fs in the stack gas of an MSWI plant using a thermal aerosol diluter coupled with a 14-stage sampler, covering particles of 10 nm-18 μm. The total emitted concentration of the PCDD/Fs was 1872.3 pg/m, corresponding to 28.8 pg TEQ /m. While particle mass concentration predominantly concentrated in the coarse mode, the size distribution of PCDD/Fs and their TEQ presented a bimodal pattern, with a major peak in the coarse mode and a secondary peak in the ultrafine mode. Heavier PCDD/Fs were abundant in coarse mode, whereas lighter PCDD/Fs were evenly associated with all size range particles. The gas particle partitioning processes via adsorption effectively explained the size distribution and homolog pattern of PCDD/Fs. The abnormal coarse mode abundance of particles after fabric filter was possibly in-stack generated by the continuous abrasion between acidic flue gas and the steel structure. PCDD/Fs from upstream of stack repartition onto the generated coarse particles, reshaping their overall size distribution. Our findings indicate that the in-stack process plays important role in PCDD/Fs emission from MSWI plants. - Source: PubMed
Publication date: 2026/03/01
Cao RongZhang YichiGeng NingboZhang HaijunChen Jiping