Ask about this productRelated genes to: ZMIZ2 Blocking Peptide
- Gene:
- ZMIZ2 NIH gene
- Name:
- zinc finger MIZ-type containing 2
- Previous symbol:
- -
- Synonyms:
- KIAA1886, hZIMP7, ZIMP7, DKFZp761I2123, NET27
- Chromosome:
- 7p13
- Locus Type:
- gene with protein product
- Date approved:
- 2006-10-24
- Date modifiied:
- 2016-02-12
Related products to: ZMIZ2 Blocking Peptide
Related articles to: ZMIZ2 Blocking Peptide
- Triple-negative breast cancer (TNBC) is highly aggressive and lacks an effective targeted therapy. This study aimed to elucidate the functions and possible mechanisms of action of zinc finger miz-type containing 2 (ZMIZ2) and minichromosome maintenance complex component 3 (MCM3) in TNBC progression. - Source: PubMed
Publication date: 2025/12/30
Zou XiaopanSun MeiyangJiang XinYu JingzeLi XiaomengNie Bingyu - ZMIZ2, a transcription co-activator, is frequently overexpressed in various tumors. However, its functional role and molecular mechanisms in driving non-small cell lung cancer (NSCLC) metastasis remain elusive. Our study reveals that ZMIZ2 is significantly overexpressed in lung adenocarcinoma (LUAD) tissues and is strongly correlated with adverse patient outcomes. Elevated ZMIZ2 expression enhances LUAD cell proliferation, migration, invasion and metastasis, whereas ZMIZ2 depletion exerts opposing effects. Mechanistically, ZMIZ2 physically interacts with PIN1 to trigger K63-linked ubiquitination-dependent PIN1 stabilization, which consequently hyperactivates the PI3K/AKT signaling axis. Notably, silencing PIN1 expression significantly attenuated ZMIZ2-mediated activation of the PI3K/AKT signaling pathway and inhibited LUAD cell proliferation, migration and invasion. Collectively, our findings establish ZMIZ2 as a novel metastasis driver that orchestrates LUAD progression through PIN1-mediated PI3K/AKT pathway activation, providing a rationale for targeting this axis in precision oncology. - Source: PubMed
Publication date: 2025/12/28
Su ZhiyueWang YuhongJin ErsuoWang FeifeiZhang WeiweiZhang YingxiLiu ZeyiWang ShengjieYang HongliQi ChangGu DongMeiLiu XiaGuo LingchuanZhang Hong-TaoLei Zhe - ZMIZ2, an androgen receptor (AR) transcriptional co-regulator, promotes prostate cancer (PCa) cell proliferation by interacting with AR to upregulate genes associated with cell proliferation; however, its specific cooperative mechanisms remain unclear. This study aims to elucidate these mechanisms. - Source: PubMed
Publication date: 2025/12/23
Yu Jing-ZeZou Xiao-PanWu Xiao-BeiCui Yang-YangWei TanDi JunFeng Xue-ChaoLi Xiao-Meng - Low birth weight in newborns is of multifactorial origin (fetal, maternal, placental, and environmental factors), and in one-third of cases, the cause is of unknown origin, with high infant morbidity and mortality. The main treatment for regaining weight and height in children with low birth weight is the application of growth hormones. However, their role as a protective factor to prevent an increase in body composition and the development of metabolic diseases is still poorly understood. : A case-control study was conducted in a cohort of patients consulted at the CES Pediatric Endocrinology Clinic, Medellín, Colombia, between 2008 and 2018. We evaluated sociodemographic and clinical variables. Additionally, the identification of differential patterns of genomic methylation between cases (treated with growth hormone) and controls (without growth hormone treatment) was performed. The groups were compared using Fisher's exact test for qualitative variables and Student's -test for the difference in means in independent samples. The correlation was evaluated with the Pearson coefficient. Regarding clinical manifestations, body mass index (BMI) was higher in children who did not receive growth hormone treatment, higher doses of growth hormone treatment helped reduce body mass index (R: -0.21, and = 0.067), and the use of growth hormone was related to a decrease in triglyceride blood concentrations ( = 0.06); these results tended towards significance. Regarding genome-wide methylation patterns, the following genes were found to be hypermethylated: , and . Meanwhile, the following genes were found hypomethylated: , and . Using growth hormone as a treatment in SGA newborns helps regain weight and height. Additionally, it could be a protective factor against the increase in adolescent body composition. - Source: PubMed
Publication date: 2025/05/23
Velásquez Juan M AlfaroVásquez Trespalacios Elsa MariaUrrego RodrigoArroyave Toro María CMontilla Velásquez María Del PilarSoto Cecilia Maria DíazVélez Juan C ZuluagaJaramillo Henríquez VerónicaFlórez Jorge Emilio SalazarMonroy Fernando PPalacio Mosquera Hernando AlirioVélez Gómez SaraPelaez Sánchez Ronald Guillermo - - Source: PubMed
Publication date: 2025/04/05
Kervarrec ThibaultOsio AmélieLouveau BaptisteMancini MaxenceBattistella Maxime