Ask about this productRelated genes to: RBBP7 Blocking Peptide
- Gene:
- RBBP7 NIH gene
- Name:
- RB binding protein 7, chromatin remodeling factor
- Previous symbol:
- -
- Synonyms:
- RbAp46
- Chromosome:
- Xp22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-01-23
- Date modifiied:
- 2016-10-05
Related products to: RBBP7 Blocking Peptide
Related articles to: RBBP7 Blocking Peptide
- Ovarian cancer (OC) remains one of the leading causes of gynecological cancer-related mortality, with limited biomarkers for early detection and prognosis. Changes in DNA methylation-stable and detectable in blood-are potential candidates for clinical application. In our earlier genome-wide methylation study involving monozygotic twins where one had ovarian cancer and the other did not, we identified two genes, RBBP7 and RIBC1, as differentially methylated. These findings laid the groundwork for further targeted investigation. - Source: PubMed
Publication date: 2026/07/29
Erdoğan Özge ŞükrüoğluErciyas Seda KılıçDemirbaş Betül ÇelikDinç AhmetÜnal ElifUğurlucan Funda GüngörÖdemiş Demet AkdenizPasin ÖzgeSaip Pınar MuallaYazıcı HülyaTuncer Seref Bugra - Polycomb repressive complex 2 (PRC2) silences MHC class I antigen presentation across cancer types, yet the role of its core scaffolding subunit SUZ12 in pancreatic ductal adenocarcinoma (PDAC) immune phenotypes remains poorly characterized. - Source: PubMed
Publication date: 2026/06/23
Wang ZhuoxinJin ChenyangYin FeiWu XuejiaoYang Zilin - Esophageal carcinoma has high mortality and poor prognosis. Current multimodal therapies remain limited by scarce actionable targets and suboptimal systemic efficacy. Tumor stemness programs sustain invasive, therapy-resistant cells and may offer new opportunities for precision stratification and treatment. - Source: PubMed
Publication date: 2026/05/19
Liu YubingYang XiaoDu RuiqinWu LanxiangWu Qingchen - The genetic contributions of the X chromosome to Alzheimer's disease (AD) remain poorly understood yet are expected to importantly shape sex differences in AD. We therefore performed large-scale X-chromosome-wide association studies (N=1,240,451), evaluating differential risk due to sex, *4, and escape from X-chromosome inactivation, finding most X-linked loci appear relevant to female-biased AD etiology. In evaluating genetic pleiotropy with hormonal, lipid, and brain imaging traits, we discovered X-linked AD loci converged on white matter traits, particularly in the anterior corona radiata and splenium of the corpus callosum. Through brain-centric functional genomics analyses, we then nominated candidate causal genes, including 5 that appeared highly robust. Notably, we found the escape gene decreases AD risk in *4 carriers likely through higher expression in excitatory neurons to counter tau-related neurodegeneration. Altogether, we provide an atlas of sex and *4-informed candidate X-linked AD risk loci, genes, and mechanisms that will guide future studies. - Source: PubMed
Publication date: 2026/05/06
Cook NoahZeng YoujieYang ChenyuJiang ZhiwenWang Ting-ChenLe Guen YannCody KarlyJohnson MatthewZhang RuiMerritt Victoria CHauger Richard L Koran Mary EllenMormino Elizabeth CGordon BrianDeCasien AlexAndrews SheaDumitrescu LoganArcher DerekHohman Timothy JPottier CyrilCruchaga CarlosSherva RichardLogue MarkNapolioni ValerioGreicius Michael DBelloy Michael E - Abnormal chromatin remodeling figures prominently in the progression and treatment of malignancies. However, the prognostic significance of chromatin remodeling-related genes (CRRGs) in hepatocellular carcinoma (HCC) has not been extensively examined. Therefore, this study aimed to identify prognostic genes associated with chromatin remodeling in HCC and to determine their prognostic significance. - Source: PubMed
Publication date: 2026/02/25
Zhou ChuangLi DingSun Lin