Ask about this productRelated genes to: TCF25 Blocking Peptide
- Gene:
- TCF25 NIH gene
- Name:
- transcription factor 25
- Previous symbol:
- -
- Synonyms:
- Nulp1, KIAA1049
- Chromosome:
- 16q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 2006-05-05
- Date modifiied:
- 2016-03-22
Related products to: TCF25 Blocking Peptide
Related articles to: TCF25 Blocking Peptide
- This study aimed to investigate the genetic diversity and population structure of Liangshan Yanying chickens and to explore the genetic basis of dorsal plumage color changes from day-old to 12 weeks of age, thereby supporting conservation and breeding strategies. A total of 11,859,518 SNPs were obtained after quality control. The average observed heterozygosity (Ho = 0.280) was lower than the expected heterozygosity (He = 0.312). The minor allele frequency (MAF) ranged predominantly between 0.10 and 0.20 (27.3 %). The LD decay analysis showed a maximum R of 0.27. Identity-by-state (IBS) distances suggested low kinship among individuals. A total of 1,726 ROH segments were identified, resulting in a low average inbreeding coefficient (FROH) of 0.0125, indicating moderate genetic diversity accompanied by a mild deficit of heterozygosity and suggesting the presence of mild inbreeding or past selection. GWAS revealed that candidate genes on chromosome 11 (DEF8, TCF25, TUBB3, DBNDD1, and MC1R) were associated with light/dark mottled plumage, while genes on chromosome 1 (GRM5, TYR, LOC121107450, and CTSC) were linked to the presence/absence of coloration. Overall, the Liangshan Yanying chicken population shows evidence of effective conservation. The variation in feather color is primarily associated with the MC1R, TYR, and other related regulatory genes, offering valuable genetic insights for the maintenance of color patterns and for the development of molecular-assisted breeding strategies. - Source: PubMed
Publication date: 2025/12/02
Yu JieWang QiangZhao JianianChen LuxiHe YuhangLi RuolanXu HengyongLi LiangBai LiliLiu HeheHuang Anqi - , the causative agent of severe malaria, predominantly reproduces through asexual stages within human red blood cells, with a small subset differentiating into transmissible gametocytes. TCF25 is recognized in other eukaryotes as a protein with dual roles: a transcriptional regulator and a key component of the Ribosome-associated Quality Control (RQC) complex. Nevertheless, the precise biological function of TCF25 in spp. remains inadequately elucidated. - Source: PubMed
Publication date: 2025/10/24
Wu JingZhang ZupingNgim ChandaraYang WenyuLi PeiyiWang FeiYe JingruLi BoTian BinZhang QingfengShang Xiaomin - Yuexi Frizzled Feather Chicken (YFC), an indigenous breed in China noted for its curly feathers, primarily comprises yellow, white, and black plumage color strains. However, the genetic mechanism underlying the regulation of plumage colors remains unknown. In this study, whole genome resequencing was employed to systematically analyze and evaluate the genetic diversity of these three distinctive plumage color strains, as well as to screen and identify crucial genes related to the plumage color. Population genetic structure analysis revealed that the YFC could be divided into 3 plumage color populations, with the yellow-feathered chickens showing the highest genetic diversity, whereas the black-feathered chickens exhibited the strongest signatures of artificial selection. Further, detection of selection signals through Fst, ROD, XPCLR indicated that 59 overlapping genes (including MC1R, CDH1, TCF25, and ZFHX3), 19 overlapping genes (including GRM5, TYR, CTSC, and RAB38), and 17 overlapping genes (including PTCH1, FBP1, and FBP2) were significantly associated with black, white, and yellow plumage color in YFC, respectively. GO annotation and KEGG pathway analysis indicated that the plumage color regulation primarily involved in cell adhesion and signal transduction, regulation and synthesis of melanin, and synthesis of biological molecules. Moreover, GWAS and Sanger sequencing revealed that the rs317806696 in the CDH1 gene was relevant to the black plumage color of YFC, while the rs317372610 and rs741501156 in the TYR gene was associated with the white plumage color. Hence, the objective of this study is to provide comprehensive genomic insights into the genetic diversity and plumage color regulation in YFC, which provide the foundation for protection of YFC genetic resources and selection of chicken breeding program for different plumage colors. - Source: PubMed
Publication date: 2025/08/13
Peng SuchengZhang LiAli SadaqatLin ShudaiLiao ZengguangPeng QiaoqiaoXie PanpanZhang Zihao - Cells adapt to nutrient limitation by activating catabolic and inhibiting anabolic pathways, yet prolonged stress may lead to cell death. How cells orchestrate metabolic adaptation and cell death to nutrient stress is poorly understood. We conduct a genome-wide CRISPR-Cas9 screen to identify regulators in glucose-starvation-induced cell death and find a group of genes in lysosomal pathway is enriched following glucose starvation. We focus on one candidate gene, Transcriptional Factor 25 (TCF25). We find TCF25 enhances lysosomal acidification by targeting V-ATPase, promoting autophagy and ATP generation under glucose starvation. However, prolonged glucose starvation constitutively activates ferritinophagy via TCF25, increasing lysosomal membrane permeability (LMP) and leading to lysosome-dependent cell death (LDCD). Knocking out TCF25 or V-ATPase components prevents cell death. Furthermore, TCF25 deficiency protects mice from hepatic ischemia-reperfusion injury. Our findings identify TCF25 as a crucial nutrient sensor that regulates lysosomal activity, offering potential therapeutic targets for metabolic and ischemic disorders. - Source: PubMed
Publication date: 2025/08/21
Ren WenqingJiang HuiSong QianqianChen YiliangTang ChenxiaoWang FangZhu JingRen JingmingZhao YaxingHe YuanCai JinZhang TianleWang ZhuhongZhu ChenjieXue WenPeng AiFeng XiaonaLiu YueYu JianqiangLiu Zheng-GangCai Zhenyu - Under the combined effects of long-term natural selection and artificial domestication, Tibetan sheep on the Qinghai-Tibet Plateau have evolved distinct ecotypes to survive extreme high-altitude conditions, including hypoxia, cold, and low oxygen levels. These ecotypic variations not only serve as an ideal model for studying plateau livestock adaptation but also harbor valuable genetic diversity. However, the lack of comprehensive genetic analyses on their adaptive and phenotypic traits has hindered the effective conservation and utilization of these resources. Using whole-genome resequencing, we systematically studied seven Tibetan sheep breeds, uncovering their genetic structure and diversity. Population analyses, including NJ and maximum likelihood trees, revealed clear genetic differentiation and migration patterns. Selective sweep analyses (Fst and θπ) identified hypoxia-related genes (DOCK8, IGF1R, JAK1, SLC47, TMTC2, and VPS13A) and wool color genes (TCF25, MITF, and MC1R). GWAS further detected candidate genes for body size traits (height, length, weight), enriched in cGMP-PKG, cAMP, and Hedgehog signaling pathways. Integrating GWAS and transcriptomics, we pinpointed key wool trait genes, including WNT16 (non-synonymous mutations), PRKCA, MAP3K8, MMP7, OVOL2 (intergenic SNPs), and COL7A1, KDM8, ZNF385D (intronic SNPs). Notably, HOX family transcription factors were found to critically regulate hair follicle development. These genetic markers offer promising targets for molecular breeding to enhance wool quality and adaptive traits. Our findings provide a genetic basis for understanding Tibetan sheep's unique adaptations and production traits, supporting future breeding strategies and sustainable utilization of their genetic resources. - Source: PubMed
Publication date: 2025/07/02
Tian DehongHan BuyingLi XuePei QuanbangZhou BaichengZhao Kai