Ask about this productRelated genes to: SFRP1 Blocking Peptide
- Gene:
- SFRP1 NIH gene
- Name:
- secreted frizzled related protein 1
- Previous symbol:
- -
- Synonyms:
- SARP2, FRP, FRP-1
- Chromosome:
- 8p11.21
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-15
- Date modifiied:
- 2016-05-04
Related products to: SFRP1 Blocking Peptide
Related articles to: SFRP1 Blocking Peptide
- Head and neck squamous cell carcinoma (HNSCC) exhibits heterogeneous responses to immunotherapy, primarily determined by the tumor immune microenvironment (TME). Accordingly, there is an urgent need for reliable biomarkers that can effectively distinguish between immune "hot" and "cold" tumors and predict prognosis and immunotherapy response. - Source: PubMed
Publication date: 2026/04/08
Li PianPang KelingZhou ZhigangYang ChaolinChen YiWu YangjieWang FujueHe Junyan - To investigate the diagnostic and prognostic value of CSPG4 and SFRP1 expression in esophageal basaloid squamous cell carcinoma (EBSCC). EBSCC cases in pathological diagnostic reports from Zhongshan Hospital, Fudan University from 2001 to 2023 were collected. Three senior pathologists independently reviewed the slides, and 81 cases of EBSCC and 55 conventional esophageal squamous cell carcinomas (ESCC) with consistent diagnoses were collected. Immunohistochemical staining for CSPG4 and SFRP1 was performed. The sensitivity and specificity of CSPG4 and SFRP1 expression in diagnosing EBSCC, as well as their correlation with prognosis, were analyzed. Among the 81 EBSCC and 55 conventional ESCC cases, there were no significant differences in patient gender, age, or surgical resection time (>0.05). The expression levels of CSPG4 and SFRP1 were significantly higher in EBSCC than in conventional ESCC (<0.001), with no significant differences across different invasive layers (>0.05). The receiver operating characteristic (ROC) curve for CSPG4 had an area under the curve (AUC) value of 0.952, with an optimal H-score cutoff of 75, showing a sensitivity of 92.6% and a specificity of 89.1% for diagnosing EBSCC. For SFRP1, the ROC curve had an AUC value of 0.880, with an optimal H-score cutoff of 1.5, showing a sensitivity of 81.5% and a specificity of 94.5%. When combined, CSPG4 and SFRP1 achieved a sensitivity of 80.2% and a specificity of 100% for diagnosing EBSCC. Among the 79 EBSCC cases with follow-up data, 17.7% showed high expression of both CSPG4 and SFRP1, 17.7% showed high CSPG4 but low SFRP1 expression, 13.9% showed low CSPG4 but high SFRP1 expression, and 50.6% showed low expression of both molecules. Compared to patients with low expression of both CSPG4 and SFRP1, those with high CSPG4 and low SFRP1 expression had the worst prognosis (disease-free survival: =0.190; overall survival: =0.031), particularly in stage Ⅰ-Ⅱ patients (disease-free survival: =0.031; overall survival: =0.013). CSPG4 and SFRP1 are primarily expressed in EBSCC. The combined application of immunohistochemical staining for these two markers can serve as a molecular indicator for the differential diagnosis and prognostic prediction of EBSCC. - Source: PubMed
Xiao Y HJiang D XYu Z XYuan WHuang JSong QZhang X LSu J A K SXu CHou Y Y - Bone loss is the most common skeletal complication of childhood acute lymphoblastic leukemia (ALL) and seriously affects the long-term survival quality of children. However, the mechanisms behind bone loss are complicated and need to be elucidated. This study seeks to examine the principal parameters influencing the osteogenic development of bone marrow mesenchymal stem cells (BMSCs) in pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL) experiencing bone loss, and to identify viable ways for alleviating bone loss. - Source: PubMed
Publication date: 2026/03/24
Li MengxiaHe XuLiu XingzhiChen MimiSun QianYu RonghuiLiu WendongWang QiSu GuanghaoShi QinWang Xiaodong - Calcium Oxalate (CaOx) kidney stones with high recurrence are a major clinical and economic health burden. Randall's Plaques (RP) serve as a nidus for CaOx stones, but it remains poorly understood how renal interstitial hydroxyapatite (HAP) deposition erodes through the papillary urothelium to create sites for urinary CaOx crystal adherence. Here, it is observed loss of urothelium above interstitial HAP deposition, and revealed that Fas Ligand (FASLG) derived from renal interstitial fibroblasts (RIFs) in HAP-rich microenvironment induced anoikis of urothelium to trigger RP exposure to urine. Mechanistically, HAP interacted with membrane protein THY1 of RIFs, which increased the affinity of THY1 to SFRP1 but suppressed its affinity to NDP, leading to activation of GSK3α/β-β-catenin pathway and thus upregulating FASLG. Moreover, the upregulated FASLG is identified as the predictor for recurrence in patients with CaOx stones following lithotripsy. Furthermore, Benarthin, a small compound binding to THY1, is found to inhibit HAP-induced FASLG and thus attenuate the anoikis of urothelium in RP mice. It is anticipated that investigations of urothelial anoikis caused by FASLG from HAP-induced fibroblasts will offer novel insights into RP exposure, enabling preventive strategies for CaOx stone formation. - Source: PubMed
Publication date: 2026/04/02
Liu MinghuiWu MaolanGao MengLi YongchaoYuan MiaoLiao ZhangchengLiu ZhiWang YizhouCui YuChen JinboHe ChengChen ZhiyongZeng FengChen HequnZhu Zewu - Hsa-miR-99a has been linked to the advancement of several malignancies, including colorectal cancer (CRC). This investigation seeks to elucidate its function and regulatory network in CRC. - Source: PubMed
Publication date: 2026/03/17
Yang XuejingZhang TingtingSun HuFeng HuijingSong Dong