Ask about this productRelated genes to: ZNF417 Blocking Peptide
- Gene:
- ZNF417 NIH gene
- Name:
- zinc finger protein 417
- Previous symbol:
- -
- Synonyms:
- MGC34079
- Chromosome:
- 19q13.43
- Locus Type:
- gene with protein product
- Date approved:
- 2003-03-17
- Date modifiied:
- 2015-09-29
Related products to: ZNF417 Blocking Peptide
Related articles to: ZNF417 Blocking Peptide
- Currently, there is only limited data on monogenic causes of vertebral defects, anorectal malformations, cardiac defects, esophageal atresia or tracheoesophageal fistula, renal malformations, and limb defects (VACTERL) association. The aim of this study was to extend the spectrum of disease-causing variants in known genes, to determine the diagnostic yield of monogenic causes, and to identify candidate genes and rare variants by applying comprehensive genetic testing or rare variant burden. - Source: PubMed
Publication date: 2024/12/09
Ćomić JasminaTilch ErikRiedhammer Korbinian MBrugger MelanieBrunet TheresaEyring KatharinaVill KatharinaRedler SilkeTasic VeliborSchmiedeke EberhardSchäfer Frank-MattiasAbazi-Emini NoraJenetzky EkkehartSchwarzer NicoleWidenmann AnkeLacher MartinZech MichaelGrasshoff-Derr SabineGeßner MichaelaKabs CarmenSeitz BarbaraHeydweiller Andreas CMuensterer OliverLange-Sperandio BärbelRolle UdoSchumacher JohannesBraunisch Matthias CBerutti RiccardoReutter HeikoHoefele Julia - Chemoresistance is the primary contributor to distant metastasis in the context of neoadjuvant chemoradiotherapy (nCRT) for rectal cancer. However, the underlying mechanisms remain elusive. - Source: PubMed
Li Gan-BinShi Wei-KunZhang XiaoQiu Xiao-YuanLin Guo-Le - Heterochromatin loss and genetic instability enhance cancer progression by favoring clonal diversity, yet uncontrolled replicative stress leads to mitotic catastrophe and inflammatory responses that promote immune rejection. KRAB domain-containing zinc finger proteins (KZFP) contribute to heterochromatin maintenance at transposable elements (TE). Here, we identified an association of upregulation of a cluster of primate-specific KZFPs with poor prognosis, increased copy-number alterations, and changes in the tumor microenvironment in diffuse large B-cell lymphoma (DLBCL). Depleting two of these KZFPs targeting evolutionarily recent TEs, ZNF587 and ZNF417, impaired the proliferation of cells derived from DLBCL and several other tumor types. ZNF587 and ZNF417 depletion led to heterochromatin redistribution, replicative stress, and cGAS-STING-mediated induction of an interferon/inflammatory response, which enhanced susceptibility to macrophage-mediated phagocytosis and increased surface expression of HLA-I, together with presentation of a neoimmunopeptidome. Thus, cancer cells can exploit KZFPs to dampen TE-originating surveillance mechanisms, which likely facilitates clonal expansion, diversification, and immune evasion. - Source: PubMed
Martins FilipeRosspopoff OlgaCarlevaro-Fita JoanaForey RomainOffner SandraPlanet EvaristPulver CyrilPak HuiSongHuber FlorianMichaux JustineBassani-Sternberg MichalTurelli PriscillaTrono Didier - Eukaryotic genomes harbor sequences derived from the chromosomal integration of ancient viruses, such as endogenous retroviruses (ERVs), which comprise 8% of the human genome. Like exogenous retroviruses, ERVs retain many common functional elements, including the corresponding DNA sequences of transfer RNA (tRNA) primer binding sites (PBSs), which are utilized for reverse transcription initiation by exogenous retroviruses. Here, through a medium-scale analysis of PBS loci positioned within ERVs, coupled with chromatin immunoprecipitation sequencing (ChIP-seq) of Kruppel-associated box zinc finger proteins (KRAB-ZFPs), we identified multiple ZFPs that specifically bind to different PBS loci. Among these, we focused on PBS-Lys, which is utilized by HIV-1, and identified its specific binding proteins to be mouse ZFP961 and human ZNF417/ZNF587. We found that these proteins not only repress ERV transcription but also inhibit retrovirus integration and transcription. Disruption of these ZFPs rendered cells more susceptible to HIV-1 infection. Thus, our research provides a methodology for identifying potential host factors that target retroviruses by ERVs. - Source: PubMed
Publication date: 2022/03/08
Yang BoFang LuGao QianqianXu CeXu JunqinChen Zhen-XiaWang YixuanYang Peng - In the first days of embryogenesis, transposable element-embedded regulatory sequences (TEeRS) are silenced by Kruppel-associated box (KRAB) zinc finger proteins (KZFPs). Many TEeRS are subsequently co-opted in transcription networks, but how KZFPs influence this process is largely unknown. We identify ZNF417 and ZNF587 as primate-specific KZFPs repressing HERVK (human endogenous retrovirus K) and SVA (SINE-VNTR-Alu) integrants in human embryonic stem cells (ESCs). Expressed in specific regions of the human developing and adult brain, ZNF417/587 keep controlling TEeRS in ESC-derived neurons and brain organoids, secondarily influencing the differentiation and neurotransmission profile of neurons and preventing the induction of neurotoxic retroviral proteins and an interferon-like response. Thus, evolutionarily recent KZFPs and their TE targets partner up to influence human neuronal differentiation and physiology. - Source: PubMed
Publication date: 2020/08/28
Turelli PriscillaPlayfoot ChristopherGrun DephineRaclot CharlènePontis JulienCoudray AlexandreThorball ChristianDuc JulienPankevich Eugenia VDeplancke BartBusskamp VolkerTrono Didier