Ask about this productRelated genes to: TTC17 Blocking Peptide
- Gene:
- TTC17 NIH gene
- Name:
- tetratricopeptide repeat domain 17
- Previous symbol:
- -
- Synonyms:
- FLJ10890
- Chromosome:
- 11p12-p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-08
- Date modifiied:
- 2019-03-20
Related products to: TTC17 Blocking Peptide
Related articles to: TTC17 Blocking Peptide
- Biliary atresia (BA) is a rare but severe neonatal cholangiopathy characterized by progressive fibro-inflammatory obstruction of the bile ducts, ultimately leading to liver failure and the need for liver transplants. Despite intensive researches, the etiology of BA remains poorly understood. Recent discoveries implicate primary cilia-solitary, microtubule-based organelles that regulate developmental signaling pathways-as central to the pathogenesis of both syndromic and non-syndromic BA. - Source: PubMed
Publication date: 2025/12/17
Shi ZhouyuanjingHan YijiangJin HaoZhang XinyaoWang LiangjingTou JinfaXie Shanshan - Circular RNA (circRNA) plays a significant role in esophagus squamous cell carcinoma (ESCC) progression. Nevertheless, circ-TTC17 roles in ESCC have not fully understood. - Source: PubMed
Publication date: 2024/12/02
Liu YingLan ShengminDuan Zhihui - Protein folding, quality control, maturation, and trafficking are essential processes for proper cellular homeostasis. Around one-third of the human proteome is targeted to the endoplasmic reticulum (ER), the organelle that serves as entrance into the secretory pathway. Successful protein trafficking is paramount for proper cellular function and to that end there are many ER resident proteins that ensure efficient secretion. Here, biochemical and cell biological analysis was used to determine that TTC17 is a large, soluble, ER-localized protein that plays an important role in secretory trafficking. Transcriptional analysis identified the predominantly expressed protein isoform of TTC17 in various cell lines. Further, TTC17 localizes to the ER and interacts with a wide variety of chaperones and cochaperones normally associated with ER protein folding, quality control, and maturation processes. TTC17 was found to be significantly upregulated by ER stress and through the creation and use of TTC17 cell lines, quantitative mass spectrometry identified secretory pathway wide trafficking defects in the absence of TTC17. Notably, trafficking of insulin-like growth factor type 1 receptor, glycoprotein nonmetastatic melanoma protein B, clusterin, and UDP-glucose:glycoprotein glucosyltransferase 1 were significantly altered in H4 neuroglioma cells. This study defines a novel ER trafficking factor and provides insight into the protein-protein assisted trafficking in the early secretory pathway. - Source: PubMed
Publication date: 2023/11/08
Canniff Nathan PGraham Jill BGuay Kevin PLubicki Daniel AEyles Stephen JRauch Jennifer NHebert Daniel N - Breast cancer (BC) metastasis is the leading cause of poor prognosis and therapeutic failure. However, the mechanisms underlying cancer metastasis are far from clear. - Source: PubMed
Publication date: 2023/03/09
Zhang JingyaoGuo FengzhuLi ChunxiaoWang YangWang JinsongSun FangzhouZhou YantongMa FeiZhang BailinQian Haili - Hypertension is a key risk factor for spontaneous coronary artery dissection (SCAD) and aortic dilation. Circulating proteins play key roles in a range of biological processes and represent a major source of druggable targets. The aim of this study was to identify circulating proteins that were associated with blood pressure (BP), SCAD and aortic dilation. We identified shared genetic variants of BP and SCAD in genome-wide association studies, searched for circulating protein affected by these variants and examined the association of circulating protein levels with BP, aortic aneurysm and dissection (AAD) and aortic diameters by integrating data from circulating protein quantitative trait loci (pQTL) studies and genome wide association study (GWAS) in individuals from the UK Biobank using two-sample Mendelian randomization analysis methods. Single nucleotide polymorphisms (SNPs) in , , , , , , , , , , and , which were related to extracellular matrix components, were associated with both BP and SCAD. We found 49 significant pQTL signals among these SNPs. The regulated proteins were encoded by , , , , , , , , , , , , and , which were enriched in biological processes such as collagen metabolic process and multicellular organism metabolic process. Causal associations between BP and AAD and aortic diameters were detected. Significant associations between circulating levels of cathepsin B, a well-known prorenin processing enzyme, and BP and aortic diameters were identified by using several Mendelian randomization analysis methods and were validated by independent data. - Source: PubMed
Publication date: 2022/03/29
Chai TianciTian MengyueYang XiaojieQiu ZhihuangLin XinjianChen Liangwan