Ask about this productRelated genes to: CATSPER2 Blocking Peptide
- Gene:
- CATSPER2 NIH gene
- Name:
- cation channel sperm associated 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 15q15.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-06-20
- Date modifiied:
- 2016-02-04
Related products to: CATSPER2 Blocking Peptide
Related articles to: CATSPER2 Blocking Peptide
- BackgroundMale infertility is a significant global health concern, with sperm motility, morphology, and capacitation being critical determinants of reproductive success. pollen has been used in traditional medicine to support male fertility, but its molecular mechanisms remain poorly defined.AimThis study aimed to elucidate the molecular interactions between dominant phytochemicals from date palm pollen and key sperm-associated proteins through a comprehensive approach.MethodsFour major phytochemicals-catechin, gallic acid, quercetin, and rutin-were selected based on concentration (>2%) and reported pharmacological relevance. Fifteen sperm-associated proteins implicated in motility, morphology, and capacitation were modeled using GalaxyTBM, Phyre2, and SWISS-MODEL, followed by structural refinement (GalaxyRefine) and validation (ERRAT, PROCHECK, Verify3D, WHAT_CHECK). Molecular docking was performed with CB-Dock2, while protein flexibility and stability were assessed by Normal Mode Analysis and Atomic Displacement Parameter analysis. Pharmacokinetic and toxicity profiles were predicted using ADMETlab 2.0.SummaryCatechin, quercetin, and gallic acid satisfied Lipinski's Rule of Five, indicating good oral bioavailability, while rutin demonstrated strong binding affinity but failed drug-likeness criteria. Rutin and quercetin exhibited the highest binding affinities with Catsper1 (-9.2 kcal/mol) and Catsper2 (-8.5 kcal/mol), respectively. These findings provide mechanistic evidence supporting the traditional use of date palm pollen in enhancing male fertility and highlight its potential as a phytotherapeutic candidate. However, this study is limited to computational approaches, and further validation through and studies is required to confirm the biological relevance of these findings. - Source: PubMed
Publication date: 2026/05/21
Esmaili MohammadNamavar Jahromi BahiaCava ClaudiaSabetian Soudabeh - This study systematically elucidated the developmental characteristics and molecular regulatory mechanisms of the testis during the critical period of sexual maturation in Kazakh horses by combining histological observation of one- and two-year-old testicular tissues with transcriptomic sequencing. In the testes of one-year-old horses, no obvious lumen was observed, and the interior is mainly comprising supporting cells and spermatogonia on the basement membrane; in contrast, in the testes of two-year-old horses, the tubular lumen was complete with spermatogonia, spermatocytes, and spermatozoa, indicating that spermatogenic function had approached maturity. Transcriptome profiling identified 979 differentially expressed genes (DEGs), with 209 up-regulated genes, including and , and 770 down-regulated genes, including . Gene Ontology (GO) annotation indicated primary enrichment of DEGs in biological processes related to multicellular organism development, cell membrane composition, and ion binding. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed significant enrichment of DEGs in the calcium signaling pathway, cell adhesion molecules, and neuroactive ligand-receptor interaction, among other key pathways. Protein-protein interaction (PPI) network analysis further highlighted core genes, including , , and . Validation by RT-qPCR confirmed the reliability of the RNA-Seq data. Our findings reveal the dynamics of testicular development in Kazakh horses through histological and molecular analyses, thereby providing a theoretical framework and candidate genes to further elucidate regulatory mechanisms and guide genetic improvement in reproductive traits. - Source: PubMed
Publication date: 2026/04/16
Su YiWen LiuxiangJiang JiaqiWen MingyueZeng YaqiMeng JunWang JianwenRen WanluYao Xinkui - This study aimed to investigate the effectiveness of intraepididymal platelet-rich plasma (PRP) administration in preventing cryopreservation-induced sperm damage in rams. Twelve adult rams were randomly assigned into two groups ( = 6) in the non-breeding season. Rams in the PRP group received 0.2 ml/per epididymis (150–200 × 10⁶ platelets) of PRP every 15 days for a total of six injections, while control group received the same volume of saline. Semen samples were collected biweekly and pooled within each group before undergoing standard cryopreservation procedures. Post-thaw analyses included morphological, functional, biochemical, and molecular assessments. Compared to the control, intraepididimal PRP significantly increased hypo-osmotic swelling (HOS) response, total and progressive motility, rapid sperm percentage, and kinetic parameters (VCL- curvilinear velocity, VSL- straight-line velocity, VAP- average path velocity), while reducing static and acrosome-damaged sperm in thawed semen. Intraepididimal PRP also enhanced catalase activity, cholesterol and myristic acid (C14:0) concentrations and the levels of steroidogenic acute regulatory protein (StAR), 3β-hydroxysteroid dehydrogenase type 1 (HSD3β1), cation channel of sperm (CatSper1), platelet-derived growth factor (PDGF), platelet-derived growth factor receptor (PDGFR), and reduced malondialdehyde level in thawed semen. Intraepididimal PRP significantly increased the mRNA presence of CatSper2, CatSper3, CatSper4, transient receptor potential melastatin 3 (TRPM3) and transient receptor potential vanilloid 5 (TRPV5) ion channels, oar-miR-3958-3p and oar-miR-125b, and decreased bta-miR-22-3p and rno-miR-494 in thawed semen. Additionally, intraepididimal PRP significantly upregulated the protein expressions of CatSper3, HSD3β2 and PDGFA, and decreased protein expressions of vascular endothelial growth factor A (VEGFA) and transforming growth factor beta 1 (TGFβ1) in thawed semen. In conclusion, intraepididymal PRP administration improved cryoresistance in ram spermatozoa, likely due to its growth factors, lipids, and antioxidants. These effects enhanced post-thaw sperm quality by modulating oxidative stress, cholesterol, ion channels, microRNAs, and steroidogenic proteins, indicating PRP as a promising tool for improving semen cryotolerance in rams. - Source: PubMed
Publication date: 2026/02/28
Cinkara Serap DayanBadıllı NidaGüngör İbrahim HalilCihangiroğlu Aslıhan ÇakırAcısu Tutku CanÖzmen Görkem KırmızıkayaArkalı GözdeBulan Mustafa SezerTektemur AhmetToraman EdipKaya Şeyma ÖzerSönmez MustafaGür SeyfettinYüce AbdurraufYılmaz ÖkkeşTürk Gaffari - The most common genes responsible for autosomal recessive nonsyndromic hearing loss (AR-NSHL) are GJB2 and STRC. STRC mutations are associated with mild-to-moderate sensorineural (SNHL) hearing loss and a lack of progression. However, our institutional experience suggested otherwise, prompting this review. - Source: PubMed
Publication date: 2026/02/02
Chan Kenny HNightengale Emily EEkhteraei SetarehSchicke ErickaTong SuhongZhu AustinBurton Barbara K - Pathogenic variants in the STRC gene are among the most common causes of autosomal recessive non-syndromic hearing loss, particularly in cases with mild-to-moderate sensorineural hearing loss (SNHL). Despite its prevalence, the clinical phenotype and natural history of STRC-related SNHL remain undercharacterized due to diagnostic challenges posed by a highly homologous pseudogene, pSTRC. This study included 23 families enrolled in the Yonsei University Hearing Loss cohort. Genetic testing was performed using either targeted deafness gene panels or whole-exome sequencing, followed by multiplex ligation-dependent probe amplification and confirmatory Sanger sequencing. A total of 23 patients with STRC-related SNHL were identified, including 12 with homozygous STRC/CATSPER2 gene deletions and 11 with other combinations of pathogenic variants. Most patients exhibited mild-to-moderate SNHL with flat or gently sloping audiometric configurations, predominantly affecting mid-to-high frequencies. No significant differences in mean PTA thresholds were observed between the two genotypic groups. Longitudinal analysis over a follow-up period of up to 4 years demonstrated stable hearing thresholds in 75% of ears, with no significant progression detected using linear mixed model analysis. Linear regression showed no age-dependent threshold shift in either ear across all genotypic subgroups. In conclusion, STRC-related hearing loss is typically mild-to-moderate, stable over time, and audiometrically similar regardless of genotypic subclassification. Given its subtle phenotype and diagnostic complexity, STRC mutations may be underrecognized without targeted screening. Incorporating STRC-specific MLPA assay into routine genetic diagnostics in patients with mild-to-moderate hearing loss may improve early detection and guide timely precision intervention. - Source: PubMed
Publication date: 2025/12/29
Cheon Tae UkJoo Sun YoungKim Sung HuhnChoi Jae YoungWon DongjuGee Heon YungJung Jinsei