Ask about this productRelated genes to: Plxdc2 Blocking Peptide
- Gene:
- PLXDC2 NIH gene
- Name:
- plexin domain containing 2
- Previous symbol:
- -
- Synonyms:
- TEM7R, FLJ14623
- Chromosome:
- 10p12.31
- Locus Type:
- gene with protein product
- Date approved:
- 2003-08-27
- Date modifiied:
- 2016-10-05
Related products to: Plxdc2 Blocking Peptide
Related articles to: Plxdc2 Blocking Peptide
- PLXDC2 is a single-pass transmembrane glycoprotein expressed in multiple stem and immune-related cell types. In human induced pluripotent stem cells (hiPSCs), PLXDC2 mRNA and its corresponding protein have been confirmed by transcriptome analysis and mass spectrometry; however, surface detection by flow cytometry using the monoclonal antibody #4G3 cannot be achieved after routine TrypLE dissociation. This failure is attributable to degradation of protease-sensitive epitopes by TrypLE and membrane-associated proteases such as BACE-1 (β-site APP cleaving enzyme 1). To retain these epitopes, we evaluated a protease-free mechanical dissociation procedure in combination with BACE-1 inhibition during both cell dissociation and antibody staining. This approach enabled reproducible flow cytometric detection of PLXDC2 on 201B7 hiPSCs. Western blot analysis of membrane fractions similarly showed increased PLXDC2 signal intensity when samples were processed in the presence of a BACE-1 inhibitor. These results demonstrate a practical method for improving PLXDC2 detection in hiPSCs and provide a general strategy for analyzing cell-surface proteins that are susceptible to proteolytic cleavage. - Source: PubMed
Publication date: 2026/07/31
Sato TomomiSakuma ChiakiHori ChikaShibata TakashiKomatsu YukiNakagawa MasatakaAkuta Teruo - Microglia are central regulators of neuroinflammation in depression. Drivers involved remain incompletely understood. Sigma non-opioid intracellular receptor 1 (S1R) is involved in brain inflammation. This study investigates how S1R regulates neuroinflammation associated with depression. - Source: PubMed
Publication date: 2026/07/15
Wang Jing-YaRen PengYang De-YiNi HanZhang ShuangYue Chen-XingZeng Zhi-RuiYuan Zeng-QiangLi Yun-Feng - Proliferative diabetic retinopathy (PDR) is one of the leading causes of blindness in working-age adults. We have previously shown that the risk of PDR is significantly elevated in individuals with intrauterine exposure to famine. However, the genetic mechanisms mediating this association remain unknown. The aim of the current study was to investigate the molecular underpinnings of famine-related PDR by performing genome-wide association (GWAS) and interaction studies (GWIS). - Source: PubMed
Publication date: 2026/06/25
Fedotkina OlenaBegum Most ChampaTrinh Xuan TungÖzgumus TurkulerÅkerlund MikaelNilsson PeterSpindola Leticia MariaLyssenko Valeriya - Primary chondrocytes often lose matrix-forming capacity during in vitro expansion, limiting scalable cartilage engineering. Here, we examined aging-independent regulation of chondrogenic function during long-term expansion of primary auricular chondrocytes and sought molecular features associated with late-passage functional decline. - Source: PubMed
Publication date: 2026/06/13
Alemujiang DilinapaTsuji NaokiSakamoto TomoakiChu Yu-YingHoshi KazutoHikita Atsuhiko - Chronic lung allograft dysfunction (CLAD) leads to declining respiratory function and high mortality, representing the main barrier to long-term survival in lung transplantation (LT). We performed the first genome-wide association study (GWAS) investigating donor's and recipient's genetic factors associated with CLAD. - Source: PubMed
Publication date: 2026/03/19
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