Ask about this productRelated genes to: TUBA1C Blocking Peptide
- Gene:
- TUBA1C NIH gene
- Name:
- tubulin alpha 1c
- Previous symbol:
- TUBA6
- Synonyms:
- MGC14580, MGC10851, bcm948
- Chromosome:
- 12q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2005-11-02
- Date modifiied:
- 2015-12-11
Related products to: TUBA1C Blocking Peptide
Related articles to: TUBA1C Blocking Peptide
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Publication date: 2026/07/30
Jiang LileYang ShujunWang YiwenXie JuankeGeng JiaxuanZhang HelongZhang YixuanWang QianChen YixuanWang XingyiZhang Cuilian - Lung adenocarcinoma (LUAD) is characterized by marked prognostic heterogeneity. Although lactylation has been implicated in tumor progression and immune regulation, the clinical relevance of lactylation-related transcriptional programs in LUAD remains insufficiently defined. This study aimed to develop and externally validate a lactylation-related gene signature for overall survival prediction in LUAD and to prioritize candidate genes for further biological investigation. - Source: PubMed
Publication date: 2026/06/24
Wang ZhiYan NuoDing TaohuiXiong WenxunFeng WeiqiangWang YunzheWei Yiping - Cirrhosis, accounting for 2.4% of global mortality in 2019, represents a leading cause of death in chronic liver disease. Hepatic encephalopathy (HE), a decompensated complication of cirrhosis, is associated with a median survival of only 0.92 years post-diagnosis. Current screening methods relying on neuropsychological tests (e.g., Psychometric Hepatic Encephalopathy Score, PHES) have limitations such as time-consuming procedures and subjective interpretation, potentially delaying diagnosis. To address this, we integrated four cirrhotic transcriptomic cohorts (GSE41919, GSE57193, GSE139602, and GSE15654) and employed an integrated algorithm (LASSO [Least Absolute Shrinkage and Selection Operator]-RFE [Recursive Feature Elimination]-random forest) to identify HE-specific biomarker genes. Ultimately, we developed an HE risk-prediction system centered on eight HE-specific marker genes, namely, , , , , , , and . Based on these genes, an XGBoost (eXtreme Gradient Boosting)-based HE risk stratification model was constructed, and SHAP (SHapley Additive exPlanations) analysis was further introduced to address the "black-box" limitation of conventional machine learning models and to improve the interpretability. The finalized eight-gene system enables accurate, efficient, and interpretable HE risk assessment in patients with cirrhosis. Functional characterization through gene set enrichment analysis and structural equation modeling further revealed that these marker genes converge on four interconnected biological processes, namely, metabolic homeostasis, synaptic and neural transmission, immune inflammatory signaling, and hepatic detoxification, which collectively reflect the gut-liver-brain axis disruption central to HE pathogenesis. This dual-model system, incorporating both cirrhosis progression and survival prognosis, provides a reliable and clinically applicable tool for early HE risk warning and stratification, reducing the limitations of traditional neuropsychological screening and offering a translational foundation for timely intervention and prognostic optimization in high-risk cirrhotic patients. - Source: PubMed
Publication date: 2026/08/01
Lan YuanfengZhao TianXu YingYe Haihong - OSTC and TUBA1C drive the malignant progression of lung adenocarcinoma (LUAD) through the modulation of N-glycosylation and the PI3K/AKT signaling pathway; Silencing these two genes markedly suppresses the malignant phenotypes of tumor cells, thereby identifying them as promising novel candidate targets for LUAD diagnosis and therapeutic intervention. - Source: PubMed
Publication date: 2026/07/16
Zhang XinyuZhou ZhengjieLian XiaofuMa ShuoChen HuiliZhang FeiyueZhang QiZhang XiangyiMin ShengpingLian Chaoqun - The mechanisms underlying the occurrence and development of breast cancer (BC) is complex. Vinorelbine-related genes (Vino-RGs) may play important roles in the treatment of BC, but their specific mechanisms remain unclear. We aimed to explore vinorelbine-related prognostic genes and their mechanisms for BC treatment. - Source: PubMed
Publication date: 2026/06/26
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