Ask about this productRelated genes to: Klhdc9 Blocking Peptide
- Gene:
- KLHDC9 NIH gene
- Name:
- kelch domain containing 9
- Previous symbol:
- -
- Synonyms:
- KARCA1
- Chromosome:
- 1q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2007-07-19
- Date modifiied:
- 2014-11-19
Related products to: Klhdc9 Blocking Peptide
Related articles to: Klhdc9 Blocking Peptide
- DNA methylation can regulate the role of long noncoding RNAs (lncRNAs) in the development of lung adenocarcinoma (LUAD). The present study aimed to identify methylation-driven lncRNAs and mRNAs as biomarkers in the prognosis of LUAD using bioinformatics analysis. - Source: PubMed
Publication date: 2019/09/27
Li RuiYang Yi-EYin Yun-HongZhang Meng-YuLi HaoQu Yi-Qing - As one of the most common malignant tumors in humans, lung cancer has experienced a gradual increase in morbidity and mortality. This study examined prognosis-related methylation-driven genes specific to lung adenocarcinoma (LUAD) to provide a basis for prognosis prediction and personalized targeted therapy for LUAD patients. - Source: PubMed
Publication date: 2018/11/26
Gao ChundiZhuang JingLi HuayaoLiu CunZhou ChaoLiu LijuanSun Changgang - Next-generation sequencing technologies have recently been used in pharmacogenomic studies to characterize large panels of cancer cell lines at the genomic and transcriptomic levels. Among these technologies, RNA-sequencing enable profiling of alternatively spliced transcripts. Given the high frequency of mRNA splicing in cancers, linking this feature to drug response will open new avenues of research in biomarker discovery. To identify robust transcriptomic biomarkers for drug response across studies, we develop a meta-analytical framework combining the pharmacological data from two large-scale drug screening datasets. We use an independent pan-cancer pharmacogenomic dataset to test the robustness of our candidate biomarkers across multiple cancer types. We further analyze two independent breast cancer datasets and find that specific isoforms of IGF2BP2, NECTIN4, ITGB6, and KLHDC9 are significantly associated with AZD6244, lapatinib, erlotinib, and paclitaxel, respectively. Our results support isoform expressions as a rich resource for biomarkers predictive of drug response. - Source: PubMed
Publication date: 2017/10/24
Safikhani ZhalehSmirnov PetrThu Kelsie LSilvester JenniferEl-Hachem NehmeQuevedo ReneLupien MathieuMak Tak WCescon DavidHaibe-Kains Benjamin - The CDK2-associated cyclin A1 is essential for spermatogenesis and contributes to leukemogenesis. The detailed molecular functions of cyclin A1 remain unclear, since the molecular networks involving cyclin A1-CDK2 have not been elucidated. Here, we identified novel cyclin A1/CDK2 interaction partners in a yeast triple-hybrid approach. Several novel proteins (INCA1, KARCA1, and PROCA1) as well as the known proteins GPS2 (G-protein pathway suppressor 2), Ku70, receptor for activated protein kinase C1/guanine nucleotide-binding protein beta-2-like-1, and mRNA-binding motif protein 4 were identified as interaction partners. These proteins link the cyclin A1-CDK2 complex to diverse cellular processes such as DNA repair, signaling, and splicing. Interactions were confirmed by GST pull-down assays and co-immunoprecipitation. We cloned and characterized the most frequently isolated unknown gene, which we named INCA1 (inhibitor of CDK interacting with cyclin A1). The nuclear INCA1 protein is evolutionarily conserved and lacks homology to any known gene. This novel protein and two other interacting partners served as substrates for the cyclin A1-CDK2 kinase complex. Cyclin A1 and all interaction partners were highly expressed in testis with varying degrees of tissue specificity. The highest expression levels were observed at different time points during testis maturation, whereas expression levels in germ cell cancers and infertile testes decreased. Taken together, we identified testicular interaction partners of the cyclin A1-CDK2 complex and studied their expression pattern in normal organs, testis development, and testicular malignancies. Thereby, we establish a new basis for future functional analyses of cyclin A1. We provide evidence that the cyclin A1-CDK2 complex plays a role in several signaling pathways important for cell cycle control and meiosis. - Source: PubMed
Publication date: 2004/05/24
Diederichs SvenBäumer NicoleJi PingMetzelder Stephan KIdos Gregory ECauvet ThomasWang WenbingMöller MariaPierschalski SarahGromoll JörgSchrader Mark GKoeffler H PhillipBerdel Wolfgang EServe HubertMüller-Tidow Carsten