Ask about this productRelated genes to: SUSD4 Blocking Peptide
- Gene:
- SUSD4 NIH gene
- Name:
- sushi domain containing 4
- Previous symbol:
- -
- Synonyms:
- FLJ10052
- Chromosome:
- 1q41
- Locus Type:
- gene with protein product
- Date approved:
- 2005-04-22
- Date modifiied:
- 2019-03-19
Related products to: SUSD4 Blocking Peptide
Related articles to: SUSD4 Blocking Peptide
- NCI-MATCH (EAY131) is a precision medicine trial using genomic testing to allocate patients with advanced malignancies to targeted treatments. Arm Y evaluated capivasertib, a pan AKT inhibitor, in patients with an -mutated tumor. Here, we report on the translational objectives of the study, a molecular and genomic analysis of specimens to identify potential biomarkers of response or resistance to capivasertib. - Source: PubMed
Publication date: 2025/03/28
McCourt Carolyn KGross JacobKalinsky KevinGuan PingMcShane Lisa MWang VictoriaO'Dwyer Peter JLahey Matthew TMaican CaydenBu XiangningPatton DavidHarris Lyndsay N - Sushi domain-containing protein 4 (SUSD4) is a complement regulatory protein whose primary function is to inhibit the complement system, and it is involved in immune regulation. The role of SUSD4 in cancer progression has largely remained elusive. SUSD4 was studied across a variety of cancer types in this study. According to the results, there is an association between the expression level of SUSD4 and prognosis in multiple types of cancer. Further analysis demonstrated that SUSD4 expression level was related to immune cell infiltration, immune-related genes, tumor heterogeneity, and multiple cancer pathways. Additionally, we validated the function of SUSD4 in colorectal cancer cell lines and found that knockdown of SUSD4 inhibited cell growth and impacted the JAK/STAT pathway. By characterizing drug sensitivity in organoids, we found that the expression of SUSD4 showed a positive correlation trend with IC50 of Selumetinib, YK-4-279, and Piperlongumine. In conclusion, SUSD4 is a valuable prognostic indicator for diverse types of cancer, and it has the potential to be a target for cancer therapy. - Source: PubMed
Publication date: 2024/04/04
Zhong YuchenZheng ChaojingZhang WeiyuanWu HongyuZhang QianLi DechuanJu HaixingFeng HaiyangChen YinboFan YongtianChen WeipingWang MengWang Guiyu - The Qinghai Province of China is located in the northeast region of the Qinghai-Tibetan Plateau (QTP) and carries abundant yak genetic resources. Previous investigations of archaeological records, mitochondrial DNA, and Y chromosomal markers have suggested that Qinghai was the major center of yak domestication. In the present study, we examined the genomic diversity, differentiation, and selection signatures of 113 Qinghai yak, including 42 newly sequenced Qinghai yak and 71 publicly available individuals, from nine yak breeds/populations (wild, Datong, Huanhu, Xueduo, Yushu, Qilian, Geermu, Tongde, and Huzhu white) using high-depth whole-genome resequencing data. We observed that most of Qinghai yak breeds/populations have abundant genomic diversity based on four genomic parameters (nucleotide diversity, inbreeding coefficients, linkage disequilibrium decay, and runs of homozygosity). Population genetic structure analysis showed that Qinghai yak have two lineages with two ancestral origins and that nine yak breeds/populations are clustered into three distinct groups of wild yak, Geermu yak, and seven other domestic yak breeds/populations. values showed moderate genetic differentiation between wild yak, Geermu yak, and the other Qinghai yak breeds/populations. Positive selection signals were detected in candidate genes associated with disease resistance (, , and ), heat stress (, , and ), pigmentation (, , and ), vision (, , and ), milk quality ( and ), neurodevelopment (, , and ), and meat quality (), using the integrated PI, composite likelihood ratio (CLR), and methods. These findings offer new insights into the genetic mechanisms underlying target traits in yak and provide important information for understanding the genomic characteristics of yak breeds/populations in Qinghai. - Source: PubMed
Publication date: 2023/01/10
Li GuangzhenLuo JingWang FuwenXu DonghuiAhmed ZulfiqarChen ShengmeiLi RuizheMa Zhijie - Sushi domain-containing protein 4 (SUSD4) is a recently discovered protein with unknown cellular functions. We previously revealed that SUSD4 can act as complement inhibitor and as a potential tumor suppressor. - Source: PubMed
Publication date: 2022/12/29
Papadakos Konstantinos SEkström AlexanderSlipek PiotrSkourti EleniReid StevenPietras KristianBlom Anna M - We present molecular cytogenetic characterization of a de novo chromosome 1q41-q42.11 microdeletion of paternal origin in a mentally retarded child of a family requesting for genetic counseling of the future pregnancy. - Source: PubMed
Chen Chih-PingChern Schu-RernWu Peih-ShanChen Shin-WenWu Fang-TzuWang Wayseen