Ask about this productRelated genes to: B4galt5 Blocking Peptide
- Gene:
- B4GALT5 NIH gene
- Name:
- beta-1,4-galactosyltransferase 5
- Previous symbol:
- -
- Synonyms:
- beta4GalT-V
- Chromosome:
- 20q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1999-03-15
- Date modifiied:
- 2016-10-05
Related products to: B4galt5 Blocking Peptide
Related articles to: B4galt5 Blocking Peptide
- Abnormal glycosylation modifications are pivotal in tumorigenesis. However, the mechanism by which Helicobacter pylori (H. pylori) infection affects glycosylation during gastric cancer (GC) progression is not well understood. This study investigated how H. pylori infection-related glycosylation contributes to GC, aiming to uncover new therapeutic targets. - Source: PubMed
Publication date: 2026/05/05
Tuo WenbinQu ZiluXiang TianYuan ChunhuiCai QinzhenLiu GaoWang JunXiang Yun - Cryopreservation of porcine blastocysts remains a significant challenge due to their high lipid content, which can lead to cryoinjury and reduced developmental competence. While liquid nitrogen (LN) vitrification causes significant molecular damage, LHe vitrification enhances oocyte viability, reduces cryoinjury, and better preserves ultrastructure and gene expression. Despite these advantages, the specific effects of LHe vitrification on porcine blastocysts are still underexplored. - Source: PubMed
Publication date: 2026/04/02
Ayantoye Jesse OluwaseunYang BaigaoDong JianhuaFeng XiaoyiShahzad MuhammadKolachi Hubdar AliWan PengchengPan HongmeiZhao Xueming - Altered cell-surface glycans are established cancer biomarkers, yet no oncogenes have been identified within glycan biosynthesis machinery. This represents a critical gap, as defining a gene as a true oncogene, rather than merely a component of an oncogenic pathway, reveals targetable dependencies that can improve clinical decisions. To date, no gain-of-function mutations have been detected in glycogenes, and the search for such mutations is largely saturated. To address this gap, we developed a bioinformatic-experimental pipeline to identify copy number alteration (CNA)-based driver genes, overcoming noise from passenger genes. The approach recovered known oncogenes and tumor suppressors, while revealing novel candidates, including glyco-oncogenes. Focusing on the glycosphingolipid (GSL) biosynthetic pathway, we validated as a bona fide glyco-oncogene whose genomic amplification drives proliferation, oncogene addiction, and poor prognosis, effects that can be reversed by targeted pathway inhibition. Mechanistic studies show that B4GALT5 promotes cancer cell survival via integrin-Src signaling under anchorage-independent conditions. Collectively, these findings establish glycosylation enzymes as a druggable oncogene class and provide a resource of high-confidence CNA-based cancer regulatory genes. - Source: PubMed
Publication date: 2026/04/01
Sahu PranoyRusso FrancescoRusso DomenicoAgliarulo IleniaAmbrosio PasqualinaRizzo RiccardoLo Monte MatteoNormanno NicolaSoddu SilviaCarlomagno FrancescaLuini AlbertoParashuraman Seetharaman - Focal segmental glomerulosclerosis (FSGS) is a major cause of nephrotic syndrome and chronic kidney disease, characterized by podocyte injury and glomerular scarring. Its heterogeneity complicates early diagnosis and treatment. - Source: PubMed
Publication date: 2026/03/24
Zhang JingkeNing HanHou YunTang Ning - Sheep have diversified into distinct breeds worldwide through both natural adaptation and human-driven selection, with hybridization serving as an effective strategy for rapid trait improvement. The Tianhua mutton sheep (TMS) is a novel breed derived from crossing South African Mutton Merino (SAMM) with Gansu alpine fine-wool sheep (GAFS). After nearly two decades of selective breeding, TMS has developed great meat quality traits and impressive cold tolerance at high altitudes. To study the genetic mechanism and provide new insights into phenotypic variation, we analyzed the genetic diversity, population structure, and selective signatures of TMS based on whole-genome sequencing of 55 TMS, 11 SAMM, and 197 public sheep genomes worldwide. - Source: PubMed
Publication date: 2026/01/31
Jiang BeixiangZeng JizeChi HuanpengShan JingfangZhang XueyingFeng QianjieLi FadiYue XiangpengFu Weiwei