Ask about this productRelated genes to: RPS15 Blocking Peptide
- Gene:
- RPS15 NIH gene
- Name:
- ribosomal protein S15
- Previous symbol:
- -
- Synonyms:
- RIG, MGC111130, S15
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-04-16
- Date modifiied:
- 2014-11-19
Related products to: RPS15 Blocking Peptide
Related articles to: RPS15 Blocking Peptide
- The genus Sida L. (Malvoideae, Malvaceae) comprises 275 species with a near-cosmopolitan distribution. Persistent taxonomic uncertainties, driven by morphological complexity and low resolution of traditional molecular markers, hinder systematic understanding of the genus. Chloroplast (cp) genomes provide genome-scale data capable of resolving these taxonomic uncertainties, but genomic resources for Sida remain limited. Here, we substantially expand cp genome sampling, perform comparative and selection analyses, identify candidate loci for species discrimination and phylogenetic inference, and conduct phylogenomic inference to clarify infrageneric relationships. - Source: PubMed
Publication date: 2026/06/09
Yan RushanSammad AbdulShah Sayed AfzalVallada AtingaTian XiaoxuanAbdullah - Recurrent point mutations in ribosomal proteins (RPs) RPL10 and RPS15 are found in T-cell acute lymphoblastic leukemia (T-ALL) and chronic lymphocytic leukemia (CLL), respectively. Furthermore, deletions of RPL5, RPL11, and RPL22 are frequent in hematologic diseases such as Diamond Blackfan Anemia, T-ALL, multiple myeloma, and in a variety of solid tumors. Yet, the role of these RP defects in dysregulation of the ribosomal translation function remains poorly understood. We engineered an isogenic RiboCancer cell line library modeling the most recurrent RP defects in blood and solid cancers and characterized it by a multi-omics translatome analysis (proteome, Ribo-seq, and total RNA-seq) as well as RiboMethSeq. Within this RiboCancer panel, CLLassociated Rps15 mutations induced the strongest alterations in mRNA translation, affecting up to 10% of expressed genes. Cryo-electron microscopy revealed that these mutations destabilize the Rps15 C-terminus and affect the translation elongation cycle dynamics by deregulating accommodation of aminoacylated tRNAs at the ribosomal A-site. This accommodation defect showed specificity for 11 codons, explaining the reduced translation efficiency of genes with high presence of these codons in Rps15-mutant cells. Notably, these genes were enriched for epigenetic and transcriptional regulators such as transcription factor Runx3, resulting in downregulation of Runx3 target genes involved in immune regulation. By developing and characterizing a unique RiboCancer cell line panel, we mapped translational rewiring driven by the most frequent somatic RP mutations. We provide unprecedented mechanistic insights into translation defects induced by CLL-associated Rps15 mutations, and reveal an intriguing translation-based rewiring of transcription in CLL. - Source: PubMed
Publication date: 2026/06/03
Astier AnaïsCaruso MarinoVereecke StijnSanto Paulo ECapron CoralieFroment CarineRinaldi DanaCabrerizo Granados DavidLeclercq MarineRoyaert JonathanVerbeeck JellePasau NaomyPlassart LauraPepe DanieleVerbruggen StevenParaqindes HermesLebaron SimonMarcel VirginieDurand SébastienChapat ClémentMenschaert GerbenClose PierreRapino FrancescaCatez FrédéricMarcoux JulienPlisson-Chastang CéliaDe Keersmaecker Kim - is one of the few genera in Crassulaceae that includes both dioecious and hermaphroditic species. However, previous studies have mainly relied on representative individuals or limited plastid fragments, which may not fully resolve evolutionary relationships within the genus, especially lineage divergence associated with sexual-system differentiation. - Source: PubMed
Publication date: 2026/05/11
Zang ErhuanZhu YandaMa DengxiuZou HongminZeng LingchaoShi LinchunLiu Jinxin - Development of castration resistance and distant metastasis remain two major clinical challenges in prostate cancer (PCa) treatment. By analyzing multiple public cancer datasets, we found that ribosomal protein S15 (RPS15) is overexpressed in PCa and related to its metastasis. Beyond its canonical role as a structural component of the ribosome, emerging evidence has highlighted the extraribosomal functions of RPS15 in disease progression. Our study demonstrates that RPS15 significantly promotes proliferation and migration in PCa through the establishment of RPS15 knockdown cells and xenograft models. Mechanistically, RPS15 interacts with the functional domain of DExD-box helicase 21 (DDX21) and facilitates the binding of DDX21 to the transcription start region of stearoyl-CoA desaturase-1 (SCD1), thereby enhancing its transcriptional activity and protein expression to drive the growth, ferroptosis-resistance, and metastasis of PCa cells. Moreover, analysis of clinical samples revealed that RPS15, DDX21, and SCD1 are concomitantly upregulated and exhibit strong positive correlations in PCa tissues. Collectively, our findings uncover the significance of the RPS15-DDX21-SCD1 axis in PCa development, expanding the understanding of noncanonical functions of ribosomal proteins and providing new insights for PCa management. - Source: PubMed
Publication date: 2026/05/07
Liao YuningSun WenshuangLi YutingDeng YuanfeiLiu QingYin ShushaXiang YujiePeng E-YingYao YuHe WanyingShao ZhenlongCai GengxiHuang Hongbiao - Our newly assembled plastomes of Dendrophthoe pentandra, a widespread mistletoe from Indonesia, reveal extensive gene loss, refined annotation, and evolutionary patterns that highlight the gradual degradation of plastomes in hemiparasites within Santalales. Mistletoes, long valued for their ecological and medicinal importance, reveal a hallmark of parasitism: chloroplast genome (plastome) reduction. Despite being the most widespread mistletoe in Indonesia, Dendrophthoe pentandra was previously represented by only two plastomes from China, limiting broader evolutionary interpretation. We report two plastomes from Indonesia and analyze them within a comparative framework spanning parasitic and non-parasitic relatives across Santalales. Both plastomes (122,298 bp and 122,291 bp) exhibited extensive gene loss, including most photosynthesis-related ndh genes as well as rpl32, rpl36, rps15, rps16, and trnK-UUU. Pseudogenization affected trnA-UGC, ycf15, ycf1, rpl2, infA, and ndhB. High-depth mapping against multiple plastome references confirmed that these features reflect genuine parasitic reduction rather than artifacts of limited sequencing depth. Our plastomes were slightly longer and had more complete gene annotations than those previously reported accessions. Despite several tRNA gene losses, amino acid frequencies and codon usage remained conserved. Additionally, 103-105 simple sequence repeats and 35-38 tandem repeats were identified as potential molecular markers. Phylogenomic analyses positioned D. pentandra within mistletoe lineages of Santalales, clearly separated from euphytoids and non-parasitic relatives. Comparative analyses revealed that plastome size reduction correlated with parasitism intensity. Gene loss, pseudogenization, and variable inverted repeat junctions further highlighted the genomic footprints of parasitism. Fine-scale alignments with close relatives showed no evidence of extreme rearrangements. Collectively, our findings support a gradual trajectory of plastome degradation in Santalales-from complete plastomes in non-parasitic species, to moderate reduction in euphytoids, and extensive loss in mistletoes-underscoring key genomic adaptations to parasitism. - Source: PubMed
Publication date: 2026/04/17
Pratiwi Risha AmiliaPriyadi AriefIriawati Prihatini IstianaEsyanti Rizkita Rachmi