MLLT4 Blocking Peptide
- Known as:
- MLLT4 Blocking Peptide
- Catalog number:
- 33r-3641
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- MLLT4 Blocking Peptide
Related genes to: MLLT4 Blocking Peptide
- Gene:
- AFDN NIH gene
- Name:
- afadin, adherens junction formation factor
- Previous symbol:
- MLLT4
- Synonyms:
- AF-6, AF6
- Chromosome:
- 6q27
- Locus Type:
- gene with protein product
- Date approved:
- 1994-09-06
- Date modifiied:
- 2016-06-28
- Gene:
- AFDN-DT NIH gene
- Name:
- AFDN divergent transcript
- Previous symbol:
- C6orf124, MLLT4-AS1, AFDN-AS1
- Synonyms:
- HGC6.4, dJ431P23.3
- Chromosome:
- 6q27
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2003-05-29
- Date modifiied:
- 2017-09-21
Related products to: MLLT4 Blocking Peptide
Related articles to: MLLT4 Blocking Peptide
- The role of ZNF165 in only a few tumors has been reported. ZNF165 plays an important role in liver cancer, gastric cancer, and breast cancer, especially in regulating the immune microenvironment, promoting tumor cell proliferation and migration, and serving as a potential target for immunotherapy. - Source: PubMed
Lyu GuizhenLi Dongbing - Emerging evidence has revealed that dysregulation of lncRNA is associated with the initiation and progression of cancer. However, the function of these lncRNAs in cancer remains largely unexplored. Here, we reported that AFDN-DT, an lncRNA that is repressed in gastric cancers (GC), functions as a tumour suppressor by inhibiting cell growth and metastasis through transcriptional repression of genes involved in metastasis. Using in vitro and in vivo models, we demonstrated that overexpression of AFDN-DT inhibited the proliferation and metastasis of GC. We found that AFDN-DT was located at the nucleus and interacted with the chromatin in gastric cells. Further, ChIRP-seq experiments and RNA-seq analysis revealed that AFDN-DT directly bound to the promoter regions and regulated the expression of genes essential for malignant transformation. Moreover, we demonstrated that DNA hypermethylation could repress AFDN-DT expression and treatment with DNA methylation inhibitors restored its expression. Collectively, the results of our study demonstrated the tumour suppressive role of AFDN-DT in GC and elucidated the transcription regulatory role of tumour suppressive lncRNAs, which can serve as potential prognostic markers for GC. - Source: PubMed
Publication date: 2020/01/24
Lai YuexingXu PingWang JingXu KaiWang LinMeng Yuchen