Ask about this productRelated genes to: KLHL14 Blocking Peptide
- Gene:
- KLHL14 NIH gene
- Name:
- kelch like family member 14
- Previous symbol:
- -
- Synonyms:
- KIAA1384
- Chromosome:
- 18q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-30
- Date modifiied:
- 2015-11-18
Related products to: KLHL14 Blocking Peptide
Related articles to: KLHL14 Blocking Peptide
- The prevalence of Type 2 diabetes mellitus (T2DM) is rapidly increasing in India, yet molecular markers that reflect early disease susceptibility remain limited. Epigenetic modifications such as DNA methylation may reflect early metabolic vulnerability preceding overt dysglycemia. In this study, we examined genome-wide DNA methylation patterns in a pilot subset nested within a prospective Indian cohort using Nanopore sequencing and assessed their associations with previously identified metabolite predictors from the same cohort. - Source: PubMed
Publication date: 2026/04/16
Satheesh GopikaAsokan Aneesh KVijayakumar GadadharanRajavelu ArumugamRao Sudha NarayanaSivakumar Krishnankutty ChandrikaJaleel Abdul - Although diffuse large B-cell lymphoma (DLBCL) has entered the era of molecular subtyping, gene mutations have not yet been used for risk stratification of patients with DLBCL. Therefore, there is an urgent need for a molecular-based model to comprehensively evaluate the prognosis of DLBCL patients in clinical practice. - Source: PubMed
Publication date: 2026/03/13
Zhang Ting-JuanWu Xiao-ChiChu Ming-QiangXu Zi-JunQiao LiangZhao Yang-JingQian JunZhou Jing-Dong - Endoplasmic Reticulum Stress (ERS), as a core mechanism of cellular response to protein homeostasis imbalance, plays a dual regulatory role in tumorigenesis and development. In this study, we aimed to analyze the regulatory network of endoplasmic reticulum stress-associated genes (ERSAGs) in oral squamous cell carcinoma (OSCC). By screening differentially expressed genes through the TCGA database, we explored the potential associations between ERS and OSCC across various aspects. We constructed an OSCC prognostic risk scoring model based on ERSRGs and validated the model's reliability using the GEO dataset as a validation set. In total, 43 differentially expressed ERSAGs were screened as well as 9 prognostic genes. Six genes (KLHL14, SLC25A4, STC2, TRIB3, ALG3, and CCNA2) were screened by Lasso regression to construct a prognostic risk score model. Further analysis suggested that KLHL14 may suppress OSCC progression by modulating tumor-infiltrating immune cells, specifically activated B cells and mast cells. Concurrently, experimental validation demonstrated that overexpression of CCNA2 significantly promotes the proliferation of OSCC. The results indicated that CCNA2 promotes the proliferation of OSCC cells cultured in vitro. This study is the first to construct a prognostic risk model for OSCC based on ERSAGs, which may assist in predicting prognosis of OSCC patients. The identified ERSAGs may contribute to the development of new therapeutic strategies, highlighting the potential clinical application value of ERS-related genes in predicting OSCC prognosis. - Source: PubMed
Publication date: 2026/03/10
Li ShuojieChen WeitingWang MaonanShu GuangYin Gang - The corticospinal tract (CST) facilitates skilled, precise movements, which necessitates that subcerebral projection neurons (SCPNs) establish segmentally specific connectivity with brainstem and spinal circuits. Developmental molecular delineation enables prospective identification of corticospinal neurons (CSNs) projecting to thoraco-lumbar spinal segments; however, it remains unclear whether other SCPN subpopulations in developing sensorimotor cortex can be prospectively identified in this manner. Such molecular tools could enable investigations of SCPN circuitry with precision and specificity. During development, Kelch-like 14 () is specifically expressed by a specific SCPN subpopulation, CSN, that reside in lateral sensorimotor cortex with axonal projections exclusively to bulbar-cervical targets. In this study, we generated Klhl14-T2A-Cre knock-in mice to investigate SCPN that are during development into maturity. Using conditional anterograde and retrograde labeling in mice of either sex, we find that Klhl14-Cre is specifically expressed by CSN only at specific developmental time points. We establish conditional viral labeling in Klhl14-T2A-Cre mice as a new approach to reliably investigate CSN axon targeting and confirm that this identifies known molecular regulators of CSN axon targeting. Therefore, Klhl14-T2A-Cre mice can be used as a novel tool for identifying molecular regulators of CST axon guidance in a relatively high-throughput manner in vivo. Finally, we demonstrate that intersectional viral labeling enables precise targeting of only Klhl14-Cre+ CSN in the adult central nervous system. Together, our results establish that developmental molecular delineation of SCPN subpopulations can be used to selectively and specifically investigate their development, as well as anatomical and functional organization into maturity. - Source: PubMed
Publication date: 2025/09/08
Lustig JakeLammers AlexanderKaiser JuliaPatel PayalRaghu AidanConner James MNguyen PhongAzim EimanSahni Vibhu - Intervertebral disc degeneration (IDD) is one of the most common diseases in the elderly population. Recently, immune disorders have been considered to play an important role in IDD. This study aimed to conduct a bioinformatic analysis to identify biomarkers associated with IDD immune cells. - Source: PubMed
Publication date: 2025/02/26
Shi Wei-HanZou Hui-ShuangWang Xiang-YuLu JieYu Hua-QiZhang Ping-PingHuang Li-LiChu Peng-ChengLiang Da-ChuanZhang Ya-NingLi Bin