Ask about this productRelated genes to: CKMT2 Blocking Peptide
- Gene:
- CKMT2 NIH gene
- Name:
- creatine kinase, mitochondrial 2
- Previous symbol:
- -
- Synonyms:
- SMTCK
- Chromosome:
- 5q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 1992-10-14
- Date modifiied:
- 2015-11-26
Related products to: CKMT2 Blocking Peptide
Related articles to: CKMT2 Blocking Peptide
- Loss of cardiomyocytes during hypoxia-reoxygenation injury contributes to adverse myocardial remodeling, resulting in hypertrophy of surviving cardiomyocytes, interstitial fibrosis, and ultimately, heart dysfunction. Despite extensive research in the field, there is currently no specific treatment available for myocardial hypoxia-reoxygenation injury to prevent cardiomyocyte death. Prenylcysteine oxidase 1 (PCYOX1) is a pro-oxidant, FAD-dependent thioether oxidase that generates hydrogen peroxide during prenylcysteine metabolism, but its role in cardiomyocytes is poorly defined. Here, using HL-1 cardiomyocytes stably silenced for Pcyox1, we show that PCYOX1 contributes to both basal and stress-induced oxidative burden and cell death. Pcyox1 silencing reduced reactive oxygen species (ROS) levels at baseline and blunted the ROS increase during ischaemic/hypoxic stress. Consistently, Pcyox1 silencing decreased apoptosis after prolonged ischaemic/hypoxic exposure. Quantitative proteomics of whole-cell lysates and isolated mitochondria revealed coordinated remodeling of pathways involved in energy buffering and contractile machinery, including increased abundance of mitochondrial creatine kinases (CKMT1/CKMT2), acetyl-CoA synthetase 2-like (ACSS1), and multiple myosin components, changes that persisted under ischaemic/hypoxic stress and after reoxygenation. Overall, these data identify PCYOX1 as a modulator of redox homeostasis and proteomic adaptation in cardiomyocytes and support PCYOX1 inhibition as a potential strategy to limit hypoxia-reoxygenation-associated injury. - Source: PubMed
Banfi CristinaBrocca LisaBascucci AlicePapaianni Giulia GiusyMallia AliceEligini Sonia - Colorectal cancer (CRC) remains a major cause of cancer-related morbidity and mortality, with high recurrence rates and limited treatment options for metastatic disease. The tumor microenvironment (TME) and metabolic reprogramming are critical drivers of CRC progression, influencing immune responses, therapeutic resistance, and patient outcomes. - Source: PubMed
Publication date: 2026/03/09
Fu YuxiangLai JianboHuang KaibinLiu LipingLiao Guixiang - Prostate adenocarcinoma (PRAD) has substantial recurrence after primary treatment, and reliable prediction is clinically needed. We integrated clinical, genomic, and transcriptomic data to identify recurrence-associated genes, characterize their tumor microenvironmental context, and develop a prognostic model. - Source: PubMed
Publication date: 2026/03/14
Ma YuanLin GaotengWang KeruoLiu ZihaoShao YuanYu WenyueZhao XiaoyiYu DanZhan FangfangWang XinghangDuan ShidaDuan KeFei - PERM1 has been identified as a key regulator of muscle energy metabolism, contractile function, and mitochondrial biogenesis. To investigate the impact fasting and acute and chronic high-intensity exercise on p38MAPK, pCaMKII, and and on PERM1 target genes (, and ) in human skeletal muscle. We performed secondary analyses of muscle biopsy samples from two previously published studies, and from one unpublished study. Muscle biopsies were analyzed from the following protocols: (1) nine men pre-, during, and post- an 8 h fast with or without 2 h of arm ergometer exercise; (2) nine men and eight women pre- and 3 h post-acute high-intensity interval cycling exercise (HIIE); and (3) eleven men and eight women pre- and post- a 6-week period of high-intensity interval training (HIIT) or nonexercise control. We used RT-PCR and Western blotting to determine the and protein levels, respectively. Immunolabelling, microscopy, and subcellular fractionation were also performed to assess PERM1 cellular localization. Fasting did not induce detectable changes in the PERM1-related pathways. HIIE significantly increased p-p38MAPK ( < 0.05, = 1.27) protein, and ( < 0.05, = 0.781) and ( < 0.05, = 1.51) mRNA. Six weeks of HIIT increased the protein levels of PERM1 isoform 2 ( < 0.05, ƞ= 0.168) and CKMT2 ( < 0.05, ƞ= 0.226). PERM1 was localized in the perinuclear region and enriched in the mitochondria. Our results suggest that only some components of PERM1-related pathways are preserved in human skeletal muscle, highlighting the importance of future studies examining PERM1 function in humans. - Source: PubMed
Menezes E SIslam HArhen B BWu ZPacitti L JLyrae Silva N MChiarot ANg S YWilkinson J ANederveen JSimpson C AMcGlory CDe Felice F GGurd B J - Sheep have diversified into distinct breeds worldwide through both natural adaptation and human-driven selection, with hybridization serving as an effective strategy for rapid trait improvement. The Tianhua mutton sheep (TMS) is a novel breed derived from crossing South African Mutton Merino (SAMM) with Gansu alpine fine-wool sheep (GAFS). After nearly two decades of selective breeding, TMS has developed great meat quality traits and impressive cold tolerance at high altitudes. To study the genetic mechanism and provide new insights into phenotypic variation, we analyzed the genetic diversity, population structure, and selective signatures of TMS based on whole-genome sequencing of 55 TMS, 11 SAMM, and 197 public sheep genomes worldwide. - Source: PubMed
Publication date: 2026/01/31
Jiang BeixiangZeng JizeChi HuanpengShan JingfangZhang XueyingFeng QianjieLi FadiYue XiangpengFu Weiwei