Ask about this productRelated genes to: DNMT3B Blocking Peptide
- Gene:
- DNMT3B NIH gene
- Name:
- DNA methyltransferase 3 beta
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 20q11.21
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-15
- Date modifiied:
- 2019-04-23
Related products to: DNMT3B Blocking Peptide
Related articles to: DNMT3B Blocking Peptide
- Neuroblastoma is one of the most common childhood tumors. As tumor suppressor genes are frequently silenced via promoter hypermethylation in cancers, targeting DNA methylation has become a promising therapeutic approach. Despite the therapeutic potential of targeting DNA methylation in neuroblastoma, conventional inhibitors of DNA methyltransferases (DNMTs) reportedly exhibit inadequate therapeutic efficacy and intolerable toxicity. Therefore, a more selective approach targeting DNA methylation enzymes that contribute to neuroblastoma progression is warranted. - Source: PubMed
Publication date: 2026/04/30
Izumi KazuyaAoki HiromasaToriuchi KohkiMiyajima ChiharuSanda TakaomiTakeshita SatoruKakita HirokiInoue YasumichiIida ShinsukeYamada YasumasaAoyama Mineyoshi - DNA methylation at the C-5 position of cytosine is an important epigenetic mechanism underpinning various cellular functions, such as heterochromatin assembly, gene expression, and cell fate determination. In mammals, DNA methylation mainly occurs in the context of CpG dinucleotide contexts. Establishment and maintenance of mammalian DNA methylation is orchestrated by two groups of functionally distinct enzymes: DNA methyltransferases DNMT3A and DNMT3B and maintenance DNA methyltransferase DNMT1. For proper genomic methylation, both and maintenance DNMTs are subjected to multilayered regulation by the chromatin environment, such as histone modifications and the methylation stiate of the CpG dinucleotide. Furthermore, DNA methylation is critically regulated by the accessory proteins of DNMTs, such as DNMT3L and DNMT3B3 for methylation and E3 ubiquitin ligase UHRF1 for maintenance DNA methylation. Increasing structural, biochemical and cellular evidence has unveiled the intricate interplay between the conformational dynamics of DNMTs and their target specification in governing the dynamic DNA demethylation across the genome. This review focuses on recent advances in structural and functional understanding of DNMTs, emphasizing how the interplay between their intramolecular and intermolecular interactions modulates the conformational dynamics and function of the individual DNA methylation machinery, thereby shaping the dynamic DNA methylation landscape across the mammalian genome. - Source: PubMed
Publication date: 2026/04/24
Song Jikui - - Source: PubMed
Publication date: 2026/04/23
Rizvi AshimaKansal RadhikaDatta Malabika - - Source: PubMed
Publication date: 2026/03/10
Chen XinJingHong Jingxuan - Distinguishing intrapulmonary metastasis (IPM) from separate primary lung cancers (SPLC) is crucial for staging and management of multiple lung cancers (MLC). Current methods lack a gold standard, limiting precise diagnosis to a subset of patients. This study introduces DNA methylation biomarkers to differentiate IPM from SPLC. - Source: PubMed
Publication date: 2026/04/15
Xu KeTan BinghuaLiang RuihaoLiang JialuHe ZhanghaiHe JianqunZhong YimingHu XuetingLei KaiLu HanlinZhang JuyongLin HuayueWang Minghui