C1orf51 Blocking Peptide
- Known as:
- C1orf51 Blocking Peptide
- Catalog number:
- 33r-3526
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- C1orf51 Blocking Peptide
Related genes to: C1orf51 Blocking Peptide
- Gene:
- CIART NIH gene
- Name:
- circadian associated repressor of transcription
- Previous symbol:
- C1orf51
- Synonyms:
- BC017397
- Chromosome:
- 1q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-02-02
- Date modifiied:
- 2014-11-19
Related products to: C1orf51 Blocking Peptide
Related articles to: C1orf51 Blocking Peptide
- Circadian and sleep-wake dysregulation have been implicated in episode recurrence and clinical heterogeneity in bipolar disorder (BD), supporting peripheral circadian markers as candidates for further investigation. This study examined the peripheral expression of selected circadian rhythm-related gene mRNAs and antisense long non-coding RNAs (lncRNAs), alongside corresponding serum protein levels and self-report-based rhythm phenotyping, in euthymic patients with BD. Sixty euthymic patients with BD (20 BD-1, 20 BD-2, and 20 with antidepressant-associated hypo/manic switch [ASHH], treated as an exploratory group) and 20 healthy controls were enrolled. Euthymia was verified by HAM-D < 7 and YMRS < 6, and chronotype and rhythm phenotypes were assessed using the MEQ, SRM-5, and BRIAN. Morning fasting blood was collected (08:00-10:00) with the morning medication dose withheld; because sampling was confined to a single morning window, the reported values represent morning transcript abundance rather than circadian rhythmicity, amplitude, or phase position. Three core clock gene mRNAs () and two antisense lncRNAs () were quantified by qRT-PCR (2^-ΔΔCt, β-actin reference), and serum CIART, CRY1, PER2, and ARNTL proteins were measured by ELISA. Between-group comparisons used nonparametric tests (Mann-Whitney U; Kruskal-Wallis H with Bonferroni post hoc), and correlations used Spearman's coefficient with Benjamini-Hochberg FDR correction. Compared with healthy controls, patients showed statistically significantly higher expression of the lncRNAs (r = 0,57) and (r = 0,49) and the mRNAs (r = 0,35) and (r = 0,29), all p ≤ 0,007, whereas mRNA did not differ (p = 0,654). In exploratory subgroup analyses, differences were concentrated in BD-2 and ASHH: BD-2 showed the highest expression and BD-1 the lowest, with BD-1 not differing from controls for any marker. Serum protein levels did not differ between groups or subgroups, and MEQ, BRIAN, and SRM-5 scores did not differ; however, a sensitivity analysis excluding shift workers revealed a chronotype difference masked in the full sample. Across 174 correlational tests, none survived FDR correction (lowest q = 0,063); nominal uncorrected associations are reported as preliminary only. In euthymic BD, peripheral expression of selected circadian rhythm-related markers-particularly the antisense lncRNAs and and the mRNAs of and - differed from healthy controls, whereas corresponding serum protein levels and behavioral rhythm phenotypes did not. This divergence across measurement levels can be considered a substantive finding, and the subgroup patterns are exploratory and hypothesis-generating. Longitudinal, episode-inclusive, and subtype-stratified studies incorporating objective circadian phase markers and repeated sampling are needed to establish the significance of peripheral transcript-level differences in BD.HIGHLIGHTS Peripheral circadian gene mRNAs and antisense lncRNAs are profiled in euthymic bipolar subtypes. and lncRNAs and and mRNAs are higher in patients than controls.Exploratory analyses: transcript differences concentrate in BD-2 and ASHH; not BD-1.Serum CIART, CRY1, PER2, and ARNTL protein levels by ELISA do not differ by group.Behavioral rhythm scores do not differ; correlations do not survive FDR correction. - Source: PubMed
Publication date: 2026/09/04
Gümüşlü Ağcabay AslıhanDemir BahadırKorkmaz MuratYumrutaş PınarSancaktar MuhammetElboğa GülçinBülbül FeridunAltındağ Abdurrahman - Disturbances in sleep and circadian rhythms are observed as sequelae of COVID-19 syndrome. However, the pathogenetic mechanisms remain largely unknown. Here, we established a fibroblast cell line (GrLBmal1-luc) from the lungs of diurnal Nile grass rats stably expressing the Bmal1-luciferase reporter gene to investigate peripheral clock regulation. First, endogenous receptor expression was screened with quantitative RT-PCR, immunohistochemistry, Ca2+ imaging, and Bmal1-luciferase reporter in GrLBmal1-luc cells. Through these, the present study discovered phase-shifting effects of adrenaline via β2-adrenoceptor. Interestingly, GrLBmal1-luc cells expressed collagen triple helix repeat containing-1 (Cthrc1) and exhibited a morphology typical of fibroblasts that accumulate in the fibrotic lungs of severe COVID-19 patients. Therefore, human angiotensin-converting enzyme-2 (ACE2) receptors were overexpressed in GrLBmal1-luc cells, and the effects of SARS-CoV-2 (Omicron, XBB.1) infection were analyzed. Following SARS-CoV-2 infection, Bmal1 transcriptions were significantly reduced, while IL-6 and Ciart transcriptions were upregulated. Rev-erbα and Per1 transcriptions were not substantially impacted. The flattened Bmal1-luciferase rhythms gradually recovered 4 days after infection, and adrenaline stimulation amplified and recovered the rhythms faster compared with unstimulated controls. These results provide insight into the molecular mechanisms underlying circadian rhythm disturbances during SARS-CoV-2 infection, and they suggest that adrenergic agents may have therapeutic potential in COVID-19 patients. - Source: PubMed
Publication date: 2026/04/02
Suga KyteKoizumi HayatoAsano YukiHamasaki ShihoriIgarashi MikuTamogami SakuraAwale SureshYamada HiroshiMorioka EriYoshikawa TomokoMochizuki TakatoshiMorinaga YoshitomoIkeda Masayuki - Osteoporosis is a prevalent disorder characterized by reduced bone mass and deterioration of bone microstructure, leading to an increased risk of fractures. The osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) plays a critical role in bone formation. Circular RNAs (circRNAs) have been implicated in various diseases, including osteoporosis, by modulating gene expression. This study explores the role of circCacna1c in osteogenic differentiation and its potential as a therapeutic target for osteoporosis. CircCacna1c expression was downregulated in OVX mice and upregulated during osteogenic differentiation of BMSCs. Overexpression of circCacna1c promoted osteogenesis by increasing key osteogenic markers, such as Runx2, Ocn, and Alp. CircCacna1c was found to act as a molecular sponge for miR-7669-3p, which targets Ciart, enhancing its expression. The miR-7669-3p/Ciart axis played a crucial role in osteogenic differentiation, with knockdown of Ciart reversing the osteogenic-promoting effects of circCacna1c. In conclusions, the circCacna1c/miR-7669-3p/Ciart pathway is involved in regulating the osteogenic differentiation of BMSCs and may serve as a potential therapeutic target for osteoporosis. Modulating circCacna1c expression or its downstream signaling could offer novel strategies for the treatment and management of osteoporosis. - Source: PubMed
Publication date: 2025/12/09
Chen ZhipengLi YanChen Bailing - Heart failure (HF) represents the end stage of cardiovascular disease and is the leading cause of mortality. The objective of this study was to identify potential biomarkers and elucidate the mechanisms underlying the development of HF across diverse populations and among different genders. - Source: PubMed
Publication date: 2025/10/14
Yu YueXue ChentianJi DongSheng WeiGao XiangWu XizeWu Chengyan - Cardiac fibrosis, marked by excessive extracellular matrix deposition, leads to heart failure. This study examines the effects of bovine milk exosomes on cardiac fibrosis in an isoproterenol-induced rat model. Rats were orally administered bovine milk exosomes, and transcriptome sequencing of the left ventricle was conducted. We identified 116 differentially expressed mRNAs (DEMs) and 141 differentially expressed lncRNAs (DELs). Key DEMs (Ciart, Cd151, Per2, Per3, H3f3c, Dbp, Tnc) and DELs (XR_001841620.1, TCONS_00025336, TCONS_00002367, TCONS_00027989, TCONS_00029872, TCONS_00036358) were significantly upregulated, as confirmed by RT-qPCR. Gene Ontology and KEGG analysis showed enrichment in circadian rhythms and immune activities. Co-expression and competing endogenous RNA networks illustrated potential regulatory mechanisms. These findings elucidate the therapeutic effects of bovine milk exosomes on cardiac fibrosis, highlighting potential targets for future clinical research. - Source: PubMed
Publication date: 2025/10/08
Hu JiajiaLu XiaoxuYan JianqinWang JianZhang JunjieZhu HongWang EZhang Chengliang