Ask about this productRelated genes to: Arsg Blocking Peptide
- Gene:
- ARSG NIH gene
- Name:
- arylsulfatase G
- Previous symbol:
- -
- Synonyms:
- KIAA1001
- Chromosome:
- 17q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 2006-02-09
- Date modifiied:
- 2015-09-11
Related products to: Arsg Blocking Peptide
Related articles to: Arsg Blocking Peptide
- Inherited retinal dystrophies (IRDs) encompass a genetically and clinically heterogeneous group of disorders, with over 300 genes currently implicated. Early and precise genetic diagnosis is critical for advancing targeted gene therapies and personalized treatment strategies. This study aims to investigate genetic findings in IRDs using whole-exome sequencing (WES) in a cohort of affected individuals. - Source: PubMed
Publication date: 2025/12/12
Keles ZulalFatihoglu Ozlem UralAyhan ZiyaSaatci Ali OCaglayan Ahmet OUlgenalp Ayfer - Deciphering rare 3--sulfated motifs in heparan sulfate (HS) is the key to understanding critical biological processes, such as viral infection and tumor progression. However, the structural analysis of these elusive structures remains highly challenging due to their low abundance and the limitations of conventional analytical approaches. In this study, we report the application of human lysosomal arylsulfatase G (ARSG), a sulfatase specifically targeting 3--sulfated glucosamine residues, as a novel enzymatic tool, which, in combination with heparinase and heparanase digestion, facilitates the identification of 3--sulfated glucosamine moieties within HS. Coupling ARSG-mediated regioselective desulfation with hydrophilic interaction liquid chromatography-mass spectrometry (HILIC-MS) enables the efficient detection and quantification of 3--sulfated oligosaccharides in HS and heparin derivatives. This approach overcomes a major analytical barrier in HS characterization and provides new insights into the distribution and functional roles of 3--sulfation. The integration of ARSG expands the enzymatic toolkit available for HS structural characterization and represents a significant advance toward elucidating the structure-function relationships of HS in health and disease. - Source: PubMed
Publication date: 2026/02/16
Poyer SaloméDenys AgnèsEl Omrani NesrineIlse Mai-BrittAllain FabriceDamme MarkusLübke TorbenDaniel Régis - Estrogen exerts a multifaceted influence on breast cancer, particularly through its association with estrogen receptor (ER) and progesterone receptor (PR), which serve as pivotal prognostic and therapeutic markers. While the differential expression of metabolic genes and their prognostic relevance in breast cancer have been extensively studied, limited research has examined their regulation by estrogen signaling. This study adopts a novel approach by investigating the effect of estrogen signaling on the expression of a broad spectrum of metabolic genes in breast cancer. - Source: PubMed
Publication date: 2025/12/01
Mazumder ArchismanSuryansh SuryanshSahoo Om SaswatSingh PrithviGoel IshaTalukdar JoyeetaSrivastava TryambakRanjan PiyushRai AvdheshDhar RubyKarmakar Subhradip - American Staffordshire Terriers (ASTs) with a c.296G>A variant in develop progressive ataxia, cerebellar atrophy, and neuronal accumulation of autofluorescent storage material. Human subjects with variants exhibit hearing loss and rod-cone dystrophy without apparent other neurological involvement and knockout mice exhibit progressive ataxia, lysosomal storage, and photoreceptor loss. Owners of 8 of 11 affected ASTs evaluated for the risk variant reported observing visual impairment in their dogs, suggesting that the canine disease may involve retinal dysfunction consistent with human subjects and mice with variants. To assess whether this might be the case, electroretinography was performed on four affected and three unaffected ASTs. Three affected dogs that were exhibiting signs of ataxia had attenuated electroretinogram (ERG) amplitudes indicative of rod and cone photoreceptor dysfunction, while ERG responses were not attenuated in a younger dog that had not yet shown signs of ataxia or visual impairment. Autofluorescent inclusions were observed in the retinal pigment epithelium and retinal ganglion cell layer of two affected dogs that were euthanized due to neurological disease progression. The results from these cases indicate that standardized electroretinography can be used to detect retinal dysfunction in dogs with the -related disorder and in other disorders in which dogs exhibit apparent impairment in visually mediated behavior. - Source: PubMed
Publication date: 2025/11/12
Kick Grace RMarzano Samantha LOta-Kuroki JuriBullock GarrettKatz Martin L - Efferocytosis, phagocytic clearance of apoptotic cells, is crucial for inflammation resolution and maintenance of tissue homeostasis. However, it is not known how epigenetic alterations govern macrophage-mediated efferocytosis. A Cleavage Under Targets and Release Using Nuclease (CUT&RUN) sequencing revealed a genome-wide selective suppression of H3K9me3, a heterochromatin mark that represses gene activity, in macrophages undergoing efferocytosis. Moreover, Recombination Signal Binding Protein for Immunoglobulin Kappa J region (RBPJ), which is a transcription factor typically involved in the canonical Notch signaling process, dampened this epigenetic modification, enhanced apoptotic cell clearance, and suppressed inflammation by mouse atherosclerotic plaque, alveolar, peritoneal, and bone marrow-derived macrophages and human primary macrophages. Inhibition of the Notch signaling in macrophages significantly reduced efferocytosis whereas activation of this signaling augmented apoptotic debris clearance. Mechanistically, RBPJ upregulated and by diminishing H3K9me3 on their promoters. promoted efferocytosis by magnifying actin polymerization via inhibition and activation of Rho and RAC GTPases, respectively. Genetic and pharmacological inhibitions of SUV39H1/H2, the methyltransferases that are responsible for H3K9 trimethylation, amplified the expression of and , and augmented efferocytosis by macrophages. In sum, this study shows epigenetic regulation of efferocytosis in tissue macrophages. - Source: PubMed
Publication date: 2025/10/12
Sadaf SamreenZhang XinyiLei LiqunShen JixingJamal ImranModugu GaneshDutta Partha