Ask about this productRelated genes to: TGIF1 Blocking Peptide
- Gene:
- TGIF1 NIH gene
- Name:
- TGFB induced factor homeobox 1
- Previous symbol:
- HPE4, TGIF
- Synonyms:
- -
- Chromosome:
- 18p11.31
- Locus Type:
- gene with protein product
- Date approved:
- 1998-01-09
- Date modifiied:
- 2016-02-02
Related products to: TGIF1 Blocking Peptide
Related articles to: TGIF1 Blocking Peptide
- People with Systemic Lupus Erythematosus (SLE) experience high levels of pain and fatigue with poor overall health, which persist in those with low disease activity. By performing epigenome-wide DNA methylation analysis, this study aims to identify epigenetic alterations associated with self-reported scores for pain, fatigue, and health in women with SLE. - Source: PubMed
Publication date: 2026/07/30
Camponeschi AlessandroRavaei AminFatima TahzeebWincup ChrisRudin AnnaBjersing JanMaglio Cristina - Interstitial lung disease (ILD) is a common but serious extra-articular manifestation of rheumatoid arthritis (RA). RA-associated ILD (RA-ILD), which often presents with the usual interstitial pneumonia (UIP) pattern, can resemble idiopathic pulmonary fibrosis (IPF), though the treatment and progression of these two conditions differ. However, the immunologic and molecular mechanisms associated with RA-ILD and IPF development have not been well elucidated at the single-cell level. - Source: PubMed
Publication date: 2026/07/28
Kim DongjunLee HyunKim Sang-HeonEun YeongheeKim Hyun JeKim Bo-Guen - : MEIS proteins are essential homeobox transcription factors that play critical roles in development and have been increasingly implicated in oncogenesis, including breast cancer. : In this study, we identified and characterized novel small-molecule MEIS2 inhibitors through in silico docking targeting the active region of the human MEIS2 homeobox domain. Lead candidates MEISi-2E, MEISi-3, and MEISi-4 were identified with binding energies ranging from -3.0 to -3.90 kcal/mol. The inhibitory potential of these molecules was validated in vitro using a species-conserved MEIS-Luciferase Reporter construct containing the TGACAG targeted locus. : Our results demonstrate that MEISi-2E, MEISi-3, and MEISi-4 significantly suppress MEIS-driven luciferase activity and downregulate the expression of , , and downstream genes such as , , , , and while upregulating negative regulator and . In breast cancer cell lines, these inhibitors exhibited potent growth inhibition, with MEISi-3 showing an exceptional IC50 as low as 0.1 μM in SK-BR-3 cells. Mechanistic studies using flow cytometry revealed that these inhibitors induce dose-dependent apoptosis and necrosis. Importantly, the novel inhibitors showed minimal toxicity to healthy human dermal and MRC5 fibroblasts, suggesting a favorable safety profile. : These findings establish these small molecules as promising therapeutic candidates for targeting MEIS2-dependent pathways in breast cancer. - Source: PubMed
Publication date: 2026/06/01
Kocabaş FatihGirgin BirkanUslu MerveSiyah PınarMermer Arif - Acute kidney injury (AKI) is a common and severe complication following renal transplantation, largely driven by ischemia-reperfusion injury (IRI). However, reliable biomarkers for post-transplant AKI remain unavailable. In this study, we analyzed transcriptomic datasets from multiple cohorts to identify robust gene signatures associated with transplant-related AKI. Weighted gene co-expression network and differential expression analyses in the discovery cohort revealed 222 candidate genes altered during early allograft IRI, which were subsequently refined in an integrated training cohort using least absolute shrinkage and selection operator (LASSO) regression and support vector machine-recursive feature elimination (SVM-RFE) to a four-gene signature comprising , , , and . This signature showed excellent discriminative performance in the training cohort (10-fold cross-validation AUC = 0.969) and was validated in independent external datasets, including a large cohort (AUC = 0.942). Decision curve analyses indicated potential clinical utility for early AKI identification across a broad threshold-probability range, with favorable performance compared with several established biomarkers such as neutrophil gelatinase-associated lipocalin. Single-cell transcriptomics revealed cell type-specific expression of the four genes across renal compartments. Moreover, their protein levels were elevated at 24 h after IRI in mouse kidneys, and displayed high expression in human AKI biopsies. Additionally, serum protein levels of SOCS3 and LETM2 were elevated in patients with cardiac surgery-associated AKI, whereas TGIF1 and MYC did not reach statistical significance. Collectively, this study identified a four-gene signature with potential utility as an early diagnostic biomarker panel for post-transplant AKI. Further large-scale clinical trials are needed to validate its diagnostic efficacy. - Source: PubMed
Publication date: 2026/06/18
Feng JinghanZhang XinniLiu JiayiSun QianPeng FangyuanRen TingZou ZhoupingLiu QinDing XiaoqiangJia Ping - Blood-based DNA methylation has been linked to obesity and metabolic health, yet its relationship to adipose tissue function remains incompletely understood. This study aimed to investigate the epigenetic regulation of EIF5A (Eukaryotic translation initiation factor 5A-1) and TGIF1 (TGFB Induced Factor Homeobox 1) across blood and adipose tissue in obesity. - Source: PubMed
Publication date: 2026/06/16
Ruf SophieHoffmann AnneMüller LuiseLandgraf KathrinVogel MandyJørsboe EmilKubitz PhilDietrich ArneGhosh AdhidebNoé FalkoWolfrum ChristianClaussnitzer MelinaHauner HansStumvoll MichaelBaber RonnyBlüher MatthiasKörner AntjeKovacs PeterKeller Maria