Ask about this productRelated genes to: HTR1A Blocking Peptide
- Gene:
- HTR1A NIH gene
- Name:
- 5-hydroxytryptamine receptor 1A
- Previous symbol:
- ADRB2RL1, ADRBRL1
- Synonyms:
- 5-HT1A
- Chromosome:
- 5q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-02-04
Related products to: HTR1A Blocking Peptide
Related articles to: HTR1A Blocking Peptide
- The serotonin system is the main therapeutic target for selective serotonin reuptake inhibitors (SSRIs) in treating depression, yet the mechanism of action of SSRIs remains incompletely understood. To investigate the molecular and transcriptional effects of SSRI administration on serotonin neurons, we performed spatial transcriptomics, a spatially resolved RNA-sequencing method in intact brain tissue. Mouse brain sections containing the dorsal raphe nucleus and adjacent midbrain structures were analyzed, revealing six distinct serotonergic subpopulations with unique molecular signatures and spatial distributions. Both acute and chronic fluoxetine treatment induced a large number of changes in gene expression in the dorsal raphe nucleus. Notably, Htr1a expression increased following acute treatment but decreased after chronic administration, supporting previous findings on serotonin transporter blockade effects on 5-HT1A autoreceptors. Gene enrichment and network analysis identified key pathways modulated by SSRI administration, including Ras, MAPK and cAMP signaling pathways as well as pathways involved in axonal guidance. Additionally, we observed treatment-dependent opposing transcriptional changes in neuropeptides, particularly Thyrotropin-releasing hormone (Trh) and Prodynorphin (Pdyn), with distinct spatial localization within the dorsal raphe nucleus. Collectively, our transcriptomic and in situ hybridization analyses reveal spatial and cell-type-specific heterogeneity in SSRI action within the dorsal raphe nucleus, providing new insights into the molecular basis of SSRI treatment effects. - Source: PubMed
Publication date: 2026/05/15
Henningson CharlottaMlost JakubPollak Dorocic Iskra - Major depressive disorder is a debilitating condition linked to dysregulated serotonin (5-HT) signaling, neuroinflammation, and oxidative stress. Boldine (BDN), a natural aporphine alkaloid with antioxidant and neuroprotective properties, might have antidepressant potential, which is still unexplored. This study investigates the effects of BDN on chronic unpredictable stress (CUS)-induced depression-like behavior in male Wistar rats. It focuses on neuroinflammation, oxidative stress, monoamine levels, and 5-HT receptor modulation. Rats were subjected to CUS for 42 days and treated with BDN (20, 40, or 80 mg/kg, po) or vortioxetine (VORT, 20 mg/kg, p.o) from the 22nd to 42nd day. Behavioral assessments (sucrose preference test, forced swim test, hole board test) revealed that BDN significantly alleviated anhedonia, despair, and anxiety-like behaviors. CUS increased serum and hippocampal cortisol, oxidative stress (elevated malondialdehyde, reduced glutathione, superoxide dismutase, catalase), and pro-inflammatory markers (NLRP3, IL-1β), which BDN effectively normalized. High-performance liquid chromatographic analysis of the brain region showed that BDN restored hippocampal dopamine, norepinephrine, and serotonin levels. RT-PCR analysis demonstrated that BDN downregulated hippocampal and upregulated gene expression, suggesting serotonergic modulation. Histopathological evaluation confirmed BDN neuroprotective effects preventing CUS-induced neuronal damage in the CA1 and CA3 hippocampal regions. These findings indicate that BDN exerts antidepressant effects by mitigating oxidative stress, suppressing NLRP3-mediated neuroinflammation, normalizing HPA axis hyperactivity, and modulating 5-HT receptor signaling. Thus, BDN represents a promising multitarget therapeutic candidate for stress-related depression. - Source: PubMed
Publication date: 2026/04/28
Akotkar LikhitAswar Urmila - Microbiome-derived deoxycholic acid (DCA) elevates serum 5-hydroxytryptamine (5-HT), a mediator of portal hypertension (PH). Rifaximin, a non-absorbable antibiotic, is known to reduce DCA levels. We aimed to elucidate the role of DCA in cirrhotic PH and the therapeutic potential of rifaximin. - Source: PubMed
Publication date: 2026/05/11
Xiong Hai-LinZhao QiLiu Shu-QingChen Li-LinNie Mei-TongHong Xia-LuDing Chen-HongHuang RuJiang NanChen FeiSong Yu-HaoZhang XinWang Ke-QiZhu Chang-PengXie Wei-Fen - Late-life depression (LLD) and chronic low back pain frequently co-occur and exacerbate one another. Outcomes with antidepressant treatment in this population are often suboptimal. Pharmacogenetic factors may help explain variability in antidepressant response. Building on prior findings suggesting that SLC6A2 variation predicts venlafaxine response in LLD, we examined whether such genetic associations extend to older adults with chronic low back pain in the ADAPT study (Addressing Depression and Pain Together). - Source: PubMed
Publication date: 2026/05/08
Kronenbuerger MartinMagarbeh LeenKloiber StefanTavakoli EmytisGorbovskaya IlonaTiwari ArunKennedy James LKarp Jordan FMuller Daniel JElsheikh Samar S M - Stunning pigs with inert gases induces less aversive behavior before loss of consciousness than stunning with high-concentration carbon dioxide (CO). As the amygdala is the center of emotional processing, we hypothesized to find differences in the amygdala transcriptome depending on the gas used for stunning. Therefore, 27 amygdala samples were collected from pigs that were stunned with either argon (Ar), a mixture of nitrogen (N) and Ar, or CO. From each sample, total RNA was isolated and sequenced. Compared with inert gases, CO stunning induced an amygdala transcriptional profile consistent with increased fear-related processing. For example, gene set enrichment analysis identified G protein‑coupled serotonin receptor activity as significantly enriched only in comparisons between CO stunning and inert‑gas stunning. In this context, HTR1A and HTR2A, which encode serotonin receptors, were downregulated in the animals stunned with CO. Both receptors have already been described to be involved in psychological disorders and fear, suggesting that CO stunning induces more fear-like emotions. Together, these transcriptomic differences support previous reports of more aversive responses during CO stunning. This study provides the first whole‑transcriptome analysis of porcine amygdalae following stunning with different gas mixtures and highlights candidate transcripts for benchmarking welfare outcomes of stunning gases. - Source: PubMed
Publication date: 2026/05/06
Gelhausen JuliaPaul Nora-FKnöll JonasWilk IngaMörlein DanielTetens JensFalker-Gieske Clemens