Ask about this productRelated genes to: PHLDB1 Blocking Peptide
- Gene:
- PHLDB1 NIH gene
- Name:
- pleckstrin homology like domain family B member 1
- Previous symbol:
- -
- Synonyms:
- FLJ00141, LL5a, KIAA0638
- Chromosome:
- 11q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-12
- Date modifiied:
- 2016-01-27
Related products to: PHLDB1 Blocking Peptide
Related articles to: PHLDB1 Blocking Peptide
- Endometrial cancer (EC) is a common gynecological tumor. Insulin resistance (IR) increases the risk of EC. However, the common molecular basis between the two remains unclear. This study aims to screen the common differential expression genes (DEGs) between the two diseases and construct a prognostic risk model. - Source: PubMed
Publication date: 2026/02/11
Lu SiyunXu JieSun XiaoXiaoYuan JieCheng JiajingQin Jinlong - Our previous study confirmed systemic lupus erythematosus (SLE) associated with polymorphisms of PHLDB1 and WDFY4 genes. In this study, we investigatedthe clinical relevance of PHLDB1 and WDFY4 in SLE pathogenesis and their potential as biomarkers. - Source: PubMed
Publication date: 2026/01/24
Zhai JianzhaoZhang LeiJia WeiPan YueZhang PingZou QingyuWu Yongkang - The germline variant rs55705857 is causal for development of mutant (mut) adult glioma. However, ~60% of mut patients do not carry the rs55705857 risk allele. We aimed to identify variants associated with developing mut glioma among patients that do not have the rs55705857 risk allele and to further understand development of wt glioma. - Source: PubMed
Publication date: 2025/07/08
Kosel Matthew LDecker Paul AKollmeyer Thomas MDrucker Kristen LShurtz Anne KMolinaro Annette MConte Gian MarcoMoassefi ManaErickson Bradley JWiencke John KFrancis StephenBurns Terry CVaubel Rachel AWrensch MargaretLachance Daniel HTobin W OliverJenkins Robert BEckel-Passow Jeanette E - Sjögren's disease (SjD) and systemic lupus erythematosus (SLE) share genetic risk at the DDX6-CXCR5 locus (11q23.3). Identifying and functionally characterising shared SNPs spanning this locus can provide new insights into common genetic mechanisms of autoimmunity. - Source: PubMed
Publication date: 2025/05/30
Wiley Mandi MRadziszewski MarcinKhatri BhuwanJoachims Michelle LTessneer Kandice LStolarczyk Anna MYao SongyuanLi JamesPritchett-Frazee CherilynJohnston Audrey ARasmussen AstridAnaya Juan-ManuelAqrawi Lara ABae Sang-CheolBaecklund EvaBjörk AlbinBrun Johan GBucher Sara MagnussonDand NickEloranta Maija-LeenaEngelke FionaForsblad-d'Elia HelenaFugmann CeciliaGlenn Stuart BGong ChenGottenberg Jacques-EricHammenfors DanielImgenberg-Kreuz JulianaJensen Janicke LiaaenJohnsen Svein Joar AuglændJonsson Malin VKelly Jennifer AKhanam SharmilyKim KwangwooKvarnström MarikaMandl ThomasMartín JavierMorris David LNocturne GaetaneNorheim Katrine BrækkeOlsson PeterPalm ØyvindPers Jacques-OlivierRhodus Nelson LSjöwall ChristopherSkarstein KathrineTaylor Kimberly ETombleson PhilThorlacius Gudny EllaVenuturupalli Swamy RVital Edward MWallace Daniel JRadfar LidaBrennan Michael TJames Judith AScofield R HalGaffney Patrick MCriswell Lindsey AJonsson RolandAppel SilkeEriksson PerBowman Simon JOmdal RoaldRönnblom LarsWarner Blake MRischmueller MaureenWitte TorstenFarris A DariseMariette XavierShiboski Caroline H Wahren-Herlenius MarieAlarcón-Riquelme Marta E Ng Wan-Fai Sivils Kathy LGuthridge Joel MAdrianto IndraVyse Timothy JTsao Betty PNordmark GunnelLessard Christopher J - Fine mapping and bioinformatic analysis of the genetic risk association in Sjögren's Disease (SjD) and Systemic Lupus Erythematosus (SLE) identified five common SNPs with functional evidence in immune cell types: rs4938573, rs57494551, rs4938572, rs4936443, rs7117261. Functional interrogation of nuclear protein binding affinity, enhancer/promoter regulatory activity, and chromatin-chromatin interactions in immune, salivary gland epithelial, and kidney epithelial cells revealed cell type-specific allelic effects for all five SNPs that expanded regulation beyond effects on and expression. Mapping the local chromatin regulatory network revealed several additional genes of interest, including . Collectively, functional characterization implicated the risk alleles of these SNPs as modulators of promoter and/or enhancer activities that regulate cell type-specific expression of , , and , among others. Further, these findings emphasize the importance of exploring the functional significance of SNPs in the context of complex chromatin architecture in disease-relevant cell types and tissues. - Source: PubMed
Publication date: 2023/10/06
Wiley Mandi MKhatri BhuwanJoachims Michelle LTessneer Kandice LStolarczyk Anna MRasmussen AstridAnaya Juan-ManuelAqrawi Lara ABae Sang-CheolBaecklund EvaBjörk AlbinBrun Johan GBucher Sara MagnussonDand NickEloranta Maija-LeenaEngelke FionaForsblad-d'Elia HelenaFugmann CeciliaGlenn Stuart BGong ChenGottenberg Jacques-EricHammenfors DanielImgenberg-Kreuz JulianaJensen Janicke LiaaenJohnsen Svein Joar AuglændJonsson Malin VKelly Jennifer AKhanam SharmilyKim KwangwooKvarnström MarikaMandl ThomasMartín JavierMorris David LNocturne GaetaneNorheim Katrine BrækkeOlsson PeterPalm ØyvindPers Jacques-OlivierRhodus Nelson LSjöwall ChristopherSkarstein KathrineTaylor Kimberly ETombleson PhilThorlacius Gudny EllaVenuturupalli SwamyVital Edward MWallace Daniel JGrundahl Kiely MRadfar LidaBrennan Michael TJames Judith AScofield R HalGaffney Patrick MCriswell Lindsey AJonsson RolandAppel SilkeEriksson PerBowman Simon JOmdal RoaldRönnblom LarsWarner Blake MRischmueller MaureenWitte TorstenFarris A DariseMariette XavierShiboski Caroline H Wahren-Herlenius MarieAlarcón-Riquelme Marta E Ng Wan-Fai Sivils Kathy LGuthridge Joel MAdrianto IndraVyse Timothy JTsao Betty PNordmark GunnelLessard Christopher J