Ask about this productRelated genes to: DOK5 Blocking Peptide
- Gene:
- DOK5 NIH gene
- Name:
- docking protein 5
- Previous symbol:
- C20orf180
- Synonyms:
- dJ805C22.1
- Chromosome:
- 20q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-07-17
- Date modifiied:
- 2015-08-27
- Gene:
- DOK6 NIH gene
- Name:
- docking protein 6
- Previous symbol:
- DOK5L
- Synonyms:
- MGC20785, HsT3226
- Chromosome:
- 18q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-05-05
- Date modifiied:
- 2015-08-27
Related products to: DOK5 Blocking Peptide
Related articles to: DOK5 Blocking Peptide
- Specific neurotrophic signaling by Trk receptors relies on the selective recruitment of downstream adaptors such as Dok5 and Dok6, yet the structural basis underlying this selectivity has remained unresolved. Here, we elucidate the principles governing Trk-Dok specificity by integrating structural prediction with biochemical validation. Comparative analysis of AlphaFold3-predicted complexes reveals that the intracellular domains of Trk dimers exhibit model-based interpretation, matching the distinct pocket architectures of Dok5 and Dok6. Ligand-induced phosphorylation exposes critical Trk tyrosine residues, enabling high-affinity engagement by adaptor PTB domains. We identify a conserved interaction hotspot centered on Trk Tyr515/516 and Dok Tyr187 that anchors this recognition. Crucially, co-immunoprecipitation assays validate that the C-terminal domains of Dok proteins exert modulatory control via steric hindrance, a finding consistent with our structural model. Collectively, our study establishes spatial complementarity and phosphorylation-dependent exposure of docking sites as key principles governing Trk-Dok signaling specificity, providing new structural insights into neurotrophin signaling and its potential therapeutic modulation. - Source: PubMed
Publication date: 2026/06/23
Wu YingyaoSun XiaojiaoChen HongyueYin BinHou LinQiang BoqinShu PengchengPeng Xiaozhong