Ask about this productRelated genes to: EPHX1 Blocking Peptide
- Gene:
- EPHX1 NIH gene
- Name:
- epoxide hydrolase 1
- Previous symbol:
- EPHX
- Synonyms:
- -
- Chromosome:
- 1q42.12
- Locus Type:
- gene with protein product
- Date approved:
- 1988-08-09
- Date modifiied:
- 2016-10-05
Related products to: EPHX1 Blocking Peptide
Related articles to: EPHX1 Blocking Peptide
- Although the COVID-19 pandemic has now been down-graded, long COVID (LC) presents an ongoing risk of long-term disease for a significant percentage of the population, even after mild or no symptoms upon infection. LC post-viral effects have been associated with oxidative stress (OS), impacting canonical cell function. The aim of this study was to investigate the association of eight OS-related single nucleotide polymorphisms (SNPs) on LC susceptibility among patients with mild or no symptoms during SARS-CoV-2 infection, with emphasis on a clinically homogeneous population free from bias and overlap with other conditions. Blood samples were collected from 85 clinically confirmed LC patients and 96 unvaccinated controls (observational case control study) all with mild/asymptomatic infection, and analysed by targeted SNP genotyping in the GSTP1, SELENOS, CAT, SOD2, and EPHX1 OS-related genes. Τhe control individuals had been infected at least 6 months prior to enrollment and had not developed any symptoms related to long COVID. Our analysis revealed associations between SOD2 and EPHX1 polymorphisms and disease progression, with pre-existing thyroid disease and acute phase symptoms being significant aggravating factors. Machine Learning (ML) analysis produced a 10-factor predictive model for LC with a balanced accuracy over 0.74, released herein as an open-access LC risk rating webtool. Our findings suggest that individuals' genetic antioxidant capacity may plays an important role in long covid, fitting with current ideas of mitochondrial dysfunction and viral persistence. It is also shown how well diagnosed and bias free cohorts can reveal patterns often missed in self-reported cases and the potential for predictive tools that combine genetic and clinical data. - Source: PubMed
Publication date: 2026/03/26
Katsarou Martha-SpyridoulaPapasavva MariaTsolakou AnniaChristodoulou AvgiAntonoglou ArchontoulaRaptis AthanasiosKontaxakis AntoniosGavrielatos MariosMichalopoulos IoannisVassiliou Alice GStefanatou MariaPappas GeorgiosMoschos Sterghios ADrakoulis NikolaosKatsaounou Paraskevi - Aspergillus flavus infection and the resulting aflatoxin contamination pose serious threats to agricultural commodities, including nutmeg (Myristica fragrans). The use of indigenous yeasts offers a promising biological strategy to suppress A. flavus and reduce aflatoxin levels. This study isolated and characterised yeasts from nutmeg leaves with the ability to decontaminate aflatoxin B1 (AFB1) and inhibit A. flavus. Eight isolates were obtained, among which DAP1 identified as Aureobasidium melanogenum exhibited the strongest activity. DAP1 achieved a 50.4% reduction of AFB1 in vitro, as quantified by HPLC, and inhibited the growth of A. flavus by 43.6% in dual-culture assays. Whole-genome sequencing of DAP1 yielded a 24 Mbp genome with a GC content of 50.14%. Genome annotation revealed putative AFB1 detoxifying genes, including cytochrome P450 monooxygenase (CYP531), glutathione transferase (GST), epoxide hydrolase (EPHX1), and aflatoxin B1 aldehyde reductase (AKR7). AntiSMASH analysis further identified biosynthetic gene clusters showing similarity to bioactive metabolites such as yanuthone (50%), lucilactaene (46%), and choline (100%). In vivo assays using nutmeg seeds confirmed the antagonistic activity of DAP1, which suppressed A. flavus growth by 58.3%. LC-MS/MS analysis showed that AFB1 levels in DAP1-treated seeds were reduced to below 1.26 ppb compared to 20.03 ppb in untreated controls. Overall, these results highlight the biocontrol potential of A. melanogenum DAP1 and its promise as a natural strategy for mitigating aflatoxin contamination in agricultural products. - Source: PubMed
Publication date: 2026/03/05
Harahap IsrawatiMaryam RomsyahSudirman Lisdar IdwanAstuti Rika Indri - Modulation of circadian rhythms impairs homeostasis, resulting in altered susceptibility to disease development. New perspectives on nutrition emphasize the circadian timing of food intake. Here, we found that the ad libitum feeding of oxidized frying oil disrupted the conversion of epoxides to diols in the kidneys, leading to aggravated renal injury. Interestingly, the circadian rhythms of epoxides and their diols in the kidneys and plasma showed differences between the light and dark phases. We demonstrated that time-imposed feeding of fried oil during the active period resulted in limited damage to renal function, conversely, renal function was impaired during the inactive period. Remarkably, feeding with epoxy stearic acid (EpSA) from fried oil during the inactive period disrupted the rhythmicity of epoxide hydrolases and related metabolites, and fueled the progression of renal fibrosis and injury. The effect of EpSA on SMA and E-cadherin, two specific biomarkers for renal inflammation and fibrosis, are lost in knockouts of Ephx1 and Ephx2, which encodes for epoxide hydrolases. In addition, dietary supplementation with linoleic acid, which inhibits epoxide hydrolases, protected mice from damage caused by time-imposed feeding of EpSA. Our findings revealed that the time-of-day dependence of epoxide hydrolases, and circadian disruption induced by time-imposed feeding of EpSA from thermo-induced oxidized oil have adverse effects on kidney function. - Source: PubMed
Publication date: 2026/02/13
Liu YanjunLu MeishanDu YanpengXu JieFan MingjieXue ChanghuLiu Yuanfa - Sheep () tail fat serves as a crucial energy reserve for adapting to harsh environments. However, excessive deposition can reduce farming efficiency and product quality. Elucidating the regulatory mechanisms of tail fat deposition is of great significance for genetic improvement in sheep. - Source: PubMed
Publication date: 2026/01/30
Gao LeiZhang YunyunZhang YiyuanPeng WeifengZhang ZhenliangLiu YuchengWang JingjingWan PengchengZhao Zongsheng - Perfluorooctanoic acid (PFOA) is associated with disrupted female endocrine and reproductive function. In this study, the ovarian impact of PFOA exposure was investigated in postpubertal pigs housed in thermal neutral (TN) or heat stress (HS) environments. Gilts (n = 48) were housed in either TN conditions (21.0 ± 0.10 °C) or cyclical HS (32.2 ± 0.1 °C to 26.2 ± 0.1 °C) for 19 days and assigned randomly to TN vehicle control (TC; n = 12), TN PFOA (TP; n = 12, 70 ng PFOA/kg), HS control (HC; n = 12), and HS PFOA (HP; n = 11; 70 ng PFOA/kg) treatments. Relative to TC, ovarian weight was decreased in TP (P = 0.03) and tended to be decreased in HP (P = 0.08). Follicular fluid estradiol tended (P = 0.08) to be decreased in HP relative to HC gilts. Dominant follicle size, vulva size, uterine weight, and follicular fluid progesterone level were not altered by treatment. The number of ovarian primordial, primary, and secondary follicles was not affected by PFOA treatment, but tertiary follicles tended (P = 0.08) to be decreased by HS. In HP gilts, there were more primordial (P = 0.05), secondary (P = 0.002), and empty (P = 0.008) follicles and a tendency for increased primary (P = 0.06) and tertiary (P = 0.08) follicles compared to TC gilts. The abundance of ovarian microsomal epoxide hydrolase (EPHX1) was reduced in HP relative to TC (P = 0.005) and HC (P = 0.006) gilts. In TP gilts, 3β-hydroxysteroid dehydrogenase (3BHSD) was reduced (P = 0.02) and both cytochrome P450 family 19 subfamily A member 1 (CYP19A1) tended (P = 0.06) to be reduced, while 3BHSD tended to be reduced in HP compared to HC gilts (P = 0.09). Thus, there were ovarian impacts of PFOA exposure in TP gilts with some additive impacts in heat-stressed pigs. - Source: PubMed
Antwi-Boasiako CollinsGonzález-Alvarez Maria EstefaníaBuol Bridget MAdeyanju OmotoyosiBaumgard Lance HKeating Aileen F