Ask about this productRelated genes to: DAAM1 Blocking Peptide
- Gene:
- DAAM1 NIH gene
- Name:
- dishevelled associated activator of morphogenesis 1
- Previous symbol:
- -
- Synonyms:
- KIAA0666
- Chromosome:
- 14q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-06
- Date modifiied:
- 2016-10-05
Related products to: DAAM1 Blocking Peptide
Related articles to: DAAM1 Blocking Peptide
- We aimed to define the genetic architecture and regulatory mechanisms of Alzheimer's disease (AD) -related plasma biomarkers in an East Asian population. - Source: PubMed
Kim Jun PyoSong MinkuCho MinyoungLee HyunwooJung Sang-HyukLim SoohyunKim ChanheeJang BeomjinShin DaeunKang HeekyoungYim SohyunJang HyeminKim Bo-HyunKim Hee JinNa Duk LAn Joon-YongZetterberg HenrikBlennow KajGonzalez-Ortiz FernandoAshton Nicholas JDay Theresa ASeo Sang WonWon Hong-Hee - Fetal development is a critical period that establishes reproductive efficiency and herd performance depending on in-utero epigenetic modifications. Dietary restrictions may affect fetal testis development and the offspring fertility. Several studies have connected genetic instability to circadian cycle disruptions, including epigenetic modifications to melatonin, a key regulator. On day 160 of gestation, 17 male-bearing Brangus heifers were assigned to one of four groups in a 2 × 2 factorial treatment arrangement: adequately fed (ADQ; 100% NRC recommendation, n = 3), nutrient restricted (RES; 60% NRC recommendation, n = 5), or ADQ or RES supplemented with 20 mg/d melatonin (ADQ-MEL, n = 5; RES-MEL, n = 4). On day 240 of gestation, heifers underwent Cesarean sections to collect fetuses and testicular tissues. The fetal testicular tissue was processed and analyzed using the Methyl-MiniSeq Service: Genome-wide bisulfite sequencing (Methyl MiniSeq-GWBS). Sequence reads from Methyl Mini-Seq libraries were identified using standard Illumina platform calling software for methylome profile. RNA-Seq libraries were then sequenced on the Illumina platform for transcriptome profile. The common genes between differentially methylated regions (DMRs) and differentially expressed genes (DEGs) across different treatment groups were identified by an overlap analysis using bedtools v2.31.1. There were 413 DMRs in RES-CON and ADQ-CON testicular tissues, without differential gene expression. Compared with the ADQ-CON group, the ADQ-MEL group showed 411 DMRs and a higher KYAT1 gene expression (P-adj <0.05) without methylation changes. Comparing RES-MEL with RES-CON showed that 9 genes (DAAM1, COL28A1, RPL10, TRPM3, SLIT, ARHGEF40, SYT1, TMEM35B, CSPG4B) were expressed more in the former (P-adj <0.05). The only hypomethylated gene was DAAM1 located on chromosome 10. However, 13 genes (PTPRU, snRNP-E, TMEM59L, MUC5B, ANAPC15, FAM221A, SHCBPiL, PAQR5, PPP4R3C, DTNB, LncRNA, SHANK2, RIC3) showed increased expression in RES-CON vs. RES-MEL without differential methylation alterations, yet there were 370 DMRs. Five genes showed increased expression in RES-MEL compared with ADQ-MEL (P-adj <0.05), including histone H2B on chromosome 23. Two genes (PTPRU, TDRD10) showed increased expression in ADQ-MEL compared with RES-MEL (P-adj <0.05) without affecting methylation and 344 DMRs. In conclusion, dietary melatonin supplementation to nutrient restricted dams may influence fetal development as epigenomic and transcriptomic regulators are altered. - Source: PubMed
El Daous HalaLittlejohn Brittni PContreras-Correa Zully ERajput ShiveeliSidelinger Darcie RKing E HeathArick Mark ALemley Caleb O - The immune response plays a critical role in determining the prognosis of breast cancer (BC) patients. However, the underlying molecular mechanisms linking immune regulation to BC progression remain uncleared. This study aims to identify and functionally validate key immune-related genes that mechanistically impact on BC prognosis. - Source: PubMed
Publication date: 2025/12/17
Chen GangZhang KunWang YidanZhang ZheCao JianqiaoGao GeYu ChaoDai YuanpingQiao GuangdongCong Yizi - With the increasing proportion of elderly individuals, understanding biological mechanisms of aging is critical. Retinal vascular complexity, measured as fractal dimension () from fundus photographs, has emerged as a vascular aging indicator. We conducted a genome-wide association study of on 74,434 participants from the Canadian Longitudinal Study on Aging, Genetics of Diabetes Audit and Research in Tayside Scotland, and UK Biobank cohorts. We identified a novel locus near . We found negative genetic correlations between and cardiovascular disease, stroke, and inflammation but a positive correlation with life span. By combining the genetic determinants of 1159 circulating proteins from the Prospective Urban and Rural Epidemiological cohort with those of using Mendelian randomization, we identified eight causal mediators, including MMP12 and IgG-Fc receptor IIb, which link higher inflammation to lower , increased cardiovascular disease risk, and shorter life span. These results extend our understanding of the biological pathways underlying aging processes and inform targets to prevention and treatment. - Source: PubMed
Publication date: 2025/10/24
Villaplana-Velasco AnaPerrot NicolasHang YuChong MichaelTrucco EmanueleMookiah Muthu R KNelson WalterPetch JeremyGerstein Hertzel CRaina ParminderYusuf SalimBernabeu Miguel OTenesa AlbertRawlik KonradPare GuillaumeDoney AlexanderPairo-Castineira ErolaPigeyre Marie - Prior studies on non-canonical Wnt signaling have established Dishevelled Associated Activator of Morphogenesis 1 (Daam1) as a crucial link in cell movements by cytoskeletal rearrangement. Overexpression or depletion of Daam1 blocks gastrulation in Xenopus embryos and results in phenotype characteristic of spina bifida. A yeast two-hybrid screen has been performed to further identify factors required downstream of Daam1. Among many, DENN (Differentially Expressed in Normal versus Neoplastic cells) domain-containing protein 5 (Dennd5A) is identified as a binding partner of Daam1. In zebrafish, dennd5a and dennd5b are human orthologues of DENND5A and DENND5B. Until now, no data on zebrafish dennd5b's expression or function is available. This current study elucidates the expression and function of the dennd5b during the early embryonic development of zebrafish. dennd5b shows 68.18% sequence similarity with human DENND5B and 68.56% with zebrafish dennd5a. Semi-quantitative RT-PCR showed maternal deposition of dennd5b at 0 h post-fertilization (hpf), continued expression through gastrulation, somite formation, and persistence into the larval stage. Spatial analysis demonstrated ubiquitous expression during cleavage and gastrulation, followed by restriction to the brain and neural tube during early somite stages, with brain-specific expression maintained through late embryogenesis and larval stage. Functional studies of dennd5b revealed compressed head and tail deformity. Both loss-of-function and gain-of-function perturbations disrupted convergence and extension movements, affecting rhombomere patterning, neural plate morphology, somite organization, notochord structure, and prechordal plate formation. Together, these findings establish dennd5b as essential for zebrafish embryogenesis, particularly in neural development, highlighting a conserved role downstream of Daam1 in non-canonical Wnt-mediated morphogenesis. - Source: PubMed
Publication date: 2025/09/25
Mendoza AliciaNassar Khaled MohamedMarston MagdalenGil AndreHasan Sharmin