Ask about this productRelated genes to: ZNF326 Blocking Peptide
- Gene:
- ZNF326 NIH gene
- Name:
- zinc finger protein 326
- Previous symbol:
- -
- Synonyms:
- Zfp326, ZAN75, FLJ20403, ZIRD
- Chromosome:
- 1p22.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-09-26
- Date modifiied:
- 2016-10-05
Related products to: ZNF326 Blocking Peptide
Related articles to: ZNF326 Blocking Peptide
- Colorectal cancer (CRC) is a leading malignant tumor worldwide with rising morbidity and mortality. Cathepsin E (CTSE), a member of the cysteinyl asparaginase family, is implicated in immune responses, antigen processing, and cellular signaling. - Source: PubMed
Publication date: 2026/03/14
Zhang HuanFeng JieZhu MengxinShi TongguoXi Qinhua - C. Deng, B. Zhang, Y. Zhang, X. Xu, D. Xiong, X. Chen, and J. Wu, "A Long Non-Coding RNA OLBC15 Promotes Triple-Negative Breast Cancer Progression Via Enhancing ZNF326 Degradation," Journal of Clinical Laboratory Analysis 34, no. 8 (2020): e23304, https://doi.org/10.1002/jcla.23304. The above article, published online on 24 April 2020, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the authors; the journal Editor-in-Chief, Rong Fu; and Wiley Periodicals, LLC. The corresponding author Jiaojiao Wu contacted the journal to request that the article be retracted for the following reasons: 1. An inability to reproduce key experimental results; 2. Technical errors in the experimental protocols that may have compromised the reliability and reproducibility of the data (inconsistencies in RNA pulldown assay conditions, potential cross-contamination in cell line experiments, and insufficient validation of antibody specificity for ZNF326 detection); and 3. Discrepancies in the original data, calling into question the western blot images in Figures 4B, 5A, and 5B; the quantification data for migration assays; and IHC scoring consistency in clinical samples. Following an investigation, images in Figures 4 and 5 were found to be duplicated from earlier publications: Figure 4D being from Figure 3A in Koo et al. 2017 (https://doi.org/10.1158/1535-7163.MCT-17-0077), Figure 5B being from Figure 5B in Shen et al. 2019 (https://doi.org/10.1002/jcla.23122), and Figure 5E being from Figure 2G in Li et al. 2018 (https://doi.org/10.2147/CMAR.S183355). Due to the scope of these errors, the editor has lost confidence in the results reported, and therefore the article must be retracted. - Source: PubMed
Publication date: 2026/01/23
- DNA replication stress (RS) is a widespread phenomenon in carcinogenesis, causing genomic instability and extensive chromatin alterations. DNA damage leads to activation of innate immune signaling, but little is known about transcriptional regulators mediating such signaling upon RS. Using a chemical screen, we identified protein arginine methyltransferase 5 (PRMT5) as a key mediator of RS-dependent induction of interferon-stimulated genes (ISGs). This response is also associated with reactivation of endogenous retroviruses (ERVs). Using quantitative mass spectrometry, we identify proteins with PRMT5-dependent symmetric dimethylarginine (SDMA) modification induced upon RS. Among these, we show that PRMT5 targets and modulates the activity of ZNF326, a zinc finger protein essential for ISG response. Our data demonstrate a role for PRMT5-mediated SDMA in the context of RS-induced transcriptional induction, affecting physiological homeostasis and cancer therapy. - Source: PubMed
Publication date: 2024/06/05
Hoang Phuong MaiTorre DenisJaynes PatrickHo JessicaMohammed KevinAlvstad ErikLam Wan YeeKhanchandani VartikaLee Jie MinToh Chin Min ClarissaLee Rui XueAnbuselvan AkshayaLee SukchanSebra Robert PMartin J Walsh Marazzi IvanKappei DennisGuccione ErnestoJeyasekharan Anand D - Ventricular fibrillation (VF) in acute myocardial infarction (AMI) is the main cause of deaths occurring in the acute phase of an ischemic event. Although it is known that genetics may play an important role in this pathology, the possible role of long non-coding RNAs (lncRNA) has never been studied. Therefore, the aim of this work is to study the expression of 10 lncRNAs in patients with and without VF in AMI. For this purpose, the expression of CDKN2B-AS1, KCNQ1OT1, LIPCAR, MALAT1, MIAT, NEAT1, SLC16A1-AS1, lnc-TK2-4:2, TNFRSF14-AS1, and UCA1 were analyzed. After the analysis and Bonferroni correction, the lncRNA CDKN2B-AS showed a statistical significance lower expression (P values of 2.514 x 10-5). In silico analysis revealed that six proteins could be related to the possible effect of lncRNA CDKN2B-AS1: AGO3, PLD4, POU4F1, ZNF26, ZNF326 and ZNF431. These in silico proteins predicted to have a low cardiac expression, although there is no literature indicating a potential relationship with VF in AMI. Thus, the lncRNA CDKN2B-AS1 shows a significant lower expression in patients with VF in AMI vs patients without VF in AMI. Literature data suggest that the role of CDKN2B1-AS is related to the miR-181a/SIRT1 pathway. - Source: PubMed
Publication date: 2024/05/21
Pan-Lizcano RicardoNúñez LucíaPiñón PabloAldama GuillermoFlores XacobeCalviño-Santos RamónVázquez-Rodríguez José ManuelHermida-Prieto Manuel - Adjuvant chemotherapy is considered for stage II colorectal cancer (CRC) patients with poor prognostic risk factors. However, current stratification algorithms are still insufficient to identify high-risk patients. - Source: PubMed
Publication date: 2024/02/28
Pu HongjiangZhang ShuaiYan ShanLi ChunxiaFu JiangpingYou DingyunZhang TaoLi Zhenhui