Ask about this productRelated genes to: MTNR1A Blocking Peptide
- Gene:
- MTNR1A NIH gene
- Name:
- melatonin receptor 1A
- Previous symbol:
- -
- Synonyms:
- MEL-1A-R
- Chromosome:
- 4q35.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-03-22
- Date modifiied:
- 2016-10-25
Related products to: MTNR1A Blocking Peptide
Related articles to: MTNR1A Blocking Peptide
- Immune checkpoint inhibitor (ICI) therapy for oral squamous cell carcinoma (OSCC) yields objective responses in fewer than 20% of patients, underscoring the urgent need for novel predictive biomarkers beyond PD-L1 expression and tumor mutational burden (TMB). Ferroptosis, an iron-dependent oxidative cell death program, has emerged as a dual-function regulator of tumor immunity. Whether ferroptotic dysregulation of the PDL stromal compartment and MT1/MT2 suppression constitute novel mechanistic determinants of ICI resistance in OSCC remains poorly understood and warrants mechanistic investigation. - Source: PubMed
Publication date: 2026/08/25
Han LuLi Conghui - In this study, we report for the first time the cloning and identification of three melatonin receptors (, , and ) from the freeze-resistant fish , all of which encode typical GPCR proteins. These receptors are expressed widely in high-metabolism tissues such as the liver. During the freezing and recovery process at -2 °C, the expression of liver receptors exhibited dynamic changes: and were significantly upregulated during the middle of resuscitation, while reached its peak expression in the later stages, suggesting its involvement in stress repair. In vitro experiments confirmed that melatonin significantly enhances the activity of liver antioxidant enzymes in a receptor-dependent manner, an effect that can be inhibited by the antagonist luzindole. Anti-inflammatory analyses indicate that melatonin primarily inhibits inflammation-related genes through and . Furthermore, the overexpression of can synergistically activate ERK in the presence of melatonin, inhibit the JNK/p38 MAPK pathway, and downregulate the expression of and . Pathway inhibition experiments further validated that the MAPK/NF-κB axis, including ERK, JNK, and p38 pathways, mediates the anti-inflammatory effects of melatonin. This study systematically elucidates the molecular mechanisms by which the melatonin receptors of play crucial antioxidant and anti-inflammatory roles during the later stages of freeze-thaw resuscitation, particularly by regulating the MAPK/NF-κB signaling axis through MTNR1A, thereby providing a novel basis for understanding the adaptation of vertebrates to extreme environments. - Source: PubMed
Publication date: 2026/08/06
Zhou JiajunLiu TianmeiNing ZhaoyangZhao XiaoyuHuang YeZhu KaitongKong XiangxinMu Weijie - Melatonin (MTN) plays a direct role in fish ovulation, and we hypothesized that aligning ovulation with an endogenous MTN peak levels could improve reproductive performance. To that, in experiment 1, we assessed circadian variation of plasma MTN in pacu () females. In experiment 2, pacu females were divided into two groups: one receiving the hypophysation dose at 7 pm (dark onset) and the other at midnight (five hours after dark). Experiment 1 showed that circulating MTN levels increased at 7 pm and remained stable through the dark phase. In experiment 2, no differences in latency or reproductive performance were observed between groups. However, MTN levels at ovulation increased significantly only in the 7 pm group. Strong positive correlations between MTN levels at ovulation and reproductive parameters, such as fertility, hatching rates, and fecundity, were observed. These results confirm that PGF2α and DHP peaks at ovulation are associated with successful ovulation in pacu, consistent with literature that shows that MTN influences ovulation by acting through the Mtnr1a receptor, triggering arachidonic acid release and prostaglandin synthesis. Our findings indicate that the timing of spawning induction influences MTN levels at ovulation, which are positively correlated with reproductive success. This is the first report linking plasma MTN levels at ovulation to successful reproductive performance in fish induced by hypophysation, highlighting the relevance of spawning timing for pacu reproduction. - Source: PubMed
Publication date: 2026/07/06
Sato Rafael Tomodade Abreu Mariana RozaSilva Laíza Maria de JesusBenevente Cristiane FernandaBatlouni Sergio Ricardo - Circadian rhythm disruption is increasingly implicated in the pathophysiology of type 2 diabetes mellitus (T2DM). Variants in core circadian clock genes - CLOCK (circadian locomotor output cycles kaput), BMAL1/ARNTL (brain and muscle ARNT-like protein 1), CRY1/2 (cryptochrome 1 and 2), PER1-3 (period 1-3), and NR1D1 (REV-ERBα) - and associated melatonin receptor genes may influence glycaemic homeostasis and insulin resistance. This systematic review synthesises evidence published between 2020 and 2025 on associations between these variants and key glycaemic parameters. A systematic search of PubMed/MEDLINE, Embase, Web of Science, and the Cochrane Library was performed following PRISMA 2020 (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Studies published from January 2020 to December 2025 that examined circadian gene variants or expression in T2DM or at-risk human populations and reported glycaemic or insulin-resistance outcomes were included. Risk of bias was independently assessed using the Newcastle-Ottawa Scale (NOS). Owing to substantial heterogeneity, a narrative synthesis following the Synthesis Without Meta-analysis (SWiM) framework was undertaken; no meta-analysis, formal heterogeneity (I²) metric, or GRADE certainty rating was performed. Six studies of diverse design (case control, cross-sectional, narrative review, and systematic review with meta-analysis) from China, South Africa, Croatia/multi-ethnic, and Spain, collectively involving more than 18,000 participants, met the inclusion criteria. A CLOCK rs1801260 × MTNR1A rs2119882 gene-gene interaction, CRY2 rs11605924, and BMAL1 rs3789327 were significantly associated with elevated fasting plasma glucose (FPG), higher Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), and increased T2DM risk. Reduced expression of core clock genes (BMAL1, CRY1, and PER2) correlated negatively with glycated haemoglobin (HbA1c) and HOMA-IR. BMAL1 rs7950226 was confirmed as a metabolic-syndrome susceptibility variant. Across 2020-2025, circadian gene variants were consistently associated with impaired glycaemic control and insulin resistance in T2DM. Because the available evidence is observational and heterogeneous, these findings suggest potential value in incorporating circadian genetic profiling into precision diabetes risk stratification rather than established causal utility, and prospective validation is required. - Source: PubMed
Publication date: 2026/06/26
Mokhtar Osman Alaa FathelrahmanTaha EzdeharHamid Mohammed Islam MustafaBakriy Mohamed Najwa MohamedAhmed Saeed WigdanMohamed WaleedAbdelkarim Ismail Abdalla Madani - Semen quality traits in chickens are critical indicators reflecting reproductive efficiency, breeding progress, and economic profitability in the poultry industry. Understanding the genetic architecture and enabling targeted genetic improvement of these traits are essential for enhancing poultry production efficiency. In this study, we estimated genetic parameters and performed weighted single-step GWAS for five semen traits in RIR chickens to reveal their genetic architecture and identify key candidate genes and QTLs associated with semen quality. The results showed that heritability estimates for SEVOL, SECON, SPMOT, SPABR, and SPCOUNT ranged from 0.097 to 0.322, indicating low to moderate heritability. 29 significant QTL regions and 12 candidate genes (NFKB1, UBE2D3, PPP3CA, EIF4E, H2AFZ, DOCK2, MTNR1A, TACC3, ADCYAP1, GFRA1, ABLIM1, and CASP7) associated with semen traits were identified by WssGWAS. These QTL regions were located on chromosomes 4 and 13 for SEVOL, chromosome 4 for SPMOT, and chromosomes 2 and 6 for SPABR. Interestingly, four prominent consecutive QTL regions were shared between SEVOL and SPMOT. These QTL were located at 59.83-61.43 Mb, explaining 11.55% and 16.33% of the genetic variance for SEVOL and SPMOT, respectively. The largest-effect SNPs within these four QTL intervals exhibited significant effects on both semen volume and sperm motility, and these markers could be used for marker-assisted selection of semen traits. This study provides further insights into the genetic architecture of chicken semen traits, improves our understanding of their molecular regulation, and identifies valuable QTL and candidate genes. These findings offer a scientific basis for genetic improvement and marker-assisted selection of semen quality. - Source: PubMed
Publication date: 2026/05/28
Tesfay Hailai HagosZhang XiaokeLi YunleiZong YunheMa ZhongHan XintongZhao YiPan ZitingMani Adamu IsaYang FujianZhang ZongyaoChen JimingSun YanyanChen Jilan