Ask about this productRelated genes to: ASZ1 Blocking Peptide
- Gene:
- ASZ1 NIH gene
- Name:
- ankyrin repeat, SAM and basic leucine zipper domain containing 1
- Previous symbol:
- C7orf7, ANKL1
- Synonyms:
- Orf3, GASZ, ALP1, CT1.19
- Chromosome:
- 7q31.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-08-23
- Date modifiied:
- 2014-11-19
Related products to: ASZ1 Blocking Peptide
Related articles to: ASZ1 Blocking Peptide
- Zirconium (Zr) based ceramic glass is a commonly utilized glass ceramic due to its exceptional mechanical and chemical properties. These materials exhibit high durability and resistance to acid attack, making them prospective materials for ionizing radiation protection applications. This study aims to evaluate the neutron and gamma radiation shielding properties of a Zirconium (Zr) based glass ceramics (ASZx) by computing the Linear attenuation coefficient (LAC), Mean free path (MFP), Half-value layer (HVL), Effective atomic number (Z), and Fast neutron removal cross-section (FNRCS) using WinXCOM at different photon energies. The samples were formulated using varying molar percentages (mol%) of Aluminum Oxide (AlO), Silicon dioxide (SiO), and Zirconia (ZrO) to produce AlO-SiO-ZrO. Results show that ASZ1 displays the highest LAC of 37.71 cm and MAC value of 10.47 cm/g at 0.015 MeV, trailed by ASZ2 and ASZ3, demonstrating that ceramic glasses with higher Zr have higher attenuation properties at lower energies. The result also showed that ASZ1 exhibited a maximum FNRCS value of 0.1072 cm indicating that a composition of ASZ1 ceramic glass is effective in fast neutron shielding than some traditional neutron shielding materials. This suggests that the ASZx ceramic glass system is a potential alternative to commercially available SCHOTT shielding glasses for some special applications. - Source: PubMed
Publication date: 2025/12/05
Echeweozo E OAl-Buriahi M SAlthagafi Talal MAlzahrani Jamila S - Pachytene piRNAs are the least understood class of piRNAs in the mammalian male germ line. During meiosis, their biogenesis occurs near mitochondrial outer membrane in germ granules known as intermitochondrial cement (IMC). However, how mitochondrial factors regulate the trafficking of PIWI proteins into and out of the IMC remain poorly understood. Here we show that the cytoplasmic PIWI proteins MILI and MIWI are recruited for pachytene piRNA biogenesis via distinct mitochondrial membrane proteins. Loss of the mitochondrial scaffold protein ASZ1 during meiosis in mice disrupts multiple downstream biogenesis steps, leading to misregulation of MILI and MIWI, failure of IMC formation, and a near-complete loss of mature pachytene piRNAs. Strikingly, despite the drastic depletion of pachytene piRNAs, LINE1 transposon silencing remains unaffected. We identify three classes of pachytene piRNA pathway components that coordinate piRNA production and compartmentalization. Our findings reveal that chromatoid body precursors serve as a central hub for the accumulation of pachytene PIWI-piRNA complexes, thus establishing a connection between IMC-based biogenesis and downstream piRNA function. - Source: PubMed
Publication date: 2025/11/04
Yan XiaoyuanWei ChaoMann Jeffrey MShang GuanyiWang QianyiXie HuirongDemireva Elena YSun LiangliangDing DeqiangChen Chen - piRNA biogenesis occurs in the intermitochondrial cement (IMC) in mammalian germ cells. The mechanisms by which IMC components engage mitochondria to form an efficient piRNA biogenesis machinery remain elusive. Here, we demonstrate that PIWI proteins orchestrate the assembly and disassembly of the piRNA biogenesis machinery in mice. The mitochondrial-anchored protein ASZ1 specifically interacts with PIWIL2 and recruits PIWIL2 to IMC granules. Sequentially, piRNAs competitively bind PIWIL2, leading to ASZ1-PIWIL2 dissociation. In fetal male germ cells, ASZ1-PIWIL2-TDRD1 forms a seed complex to initiate the assembly of the piRNA biogenesis machinery. During postnatal meiosis, the TDRKH-PIWIL1-TDRD1 complex synergizes with the ASZ1-PIWIL2-TDRD1 complex to induce substantial IMC assembly and pachytene piRNA biogenesis through TDRD1-mediated phase separation. PIWI proteins act as bridges, tethering non-mitochondrial proteins to mitochondrial-anchored proteins in IMC granules with the assistance of TDRD1. Together, our findings establish the pivotal role of PIWI proteins in governing the spatiotemporal dynamics of piRNA biogenesis machinery during mammalian spermatogenesis. - Source: PubMed
Publication date: 2025/09/29
Gao JieChen CanmeiShang GuanyiYu WenyangZhao TingZhang YunfangChen ChenDing Deqiang - Germ cells are essential for fertility, embryogenesis, and reproduction. Germline development requires distinct types of germ granules, which contains RNA-protein (RNP) complexes, including germ plasm in embryos, piRNA granules in gonadal germ cells, and the Balbiani body (Bb) in oocytes. However, the regulation of RNP assemblies in zebrafish germline development are still poorly understood. Asz1 is a piRNA protein in Drosophila and mice. Zebrafish Asz1 localizes to both piRNA and Bb granules, with yet unknown functions. Here, we hypothesized that Asz1 functions in germ granules and germline development in zebrafish. We generated asz1 mutant fish to determine the roles of Asz1 in germ cell development. We show that Asz1 is dispensable for somatic development, but essential for germ cell and gonad development. asz1-/- fish developed exclusively as sterile males with severely underdeveloped testes that lacked germ cells. In asz1 mutant juvenile gonads, germ cells undergo extensive apoptosis, demonstrating that Asz1 is essential for germ cell survival. Mechanistically, we provide evidence to conclude that zygotic Asz1 is not required for primordial germ cell specification or migration to the gonad, but is essential during post-embryonic gonad development, likely by suppressing the expression of germline transposons. Increased transposon expression and mis-organized piRNA granules in asz1 mutants, argue that zebrafish Asz1 functions in the piRNA pathway. We generated asz1;tp53 fish to partially rescue ovarian development, revealing that Asz1 is also essential for oogenesis. We further showed that in contrast with piRNA granules, Asz1 is dispensable for Bb granule formation, as shown by normal Bb localization of Buc and dazl. By uncovering Asz1 as an essential regulator of germ cell survival and gonadogenesis in zebrafish, and determining its differential necessity in distinct germ granule types, our work advances our understanding of the developmental genetics of reproduction and fertility, as well as of germ granule biology. - Source: PubMed
Publication date: 2025/01/13
Ahmad AdamBogoch YoelShvaizer GalGuler NogaLevy KarineElkouby Yaniv M - Spermatogenesis is a highly regulated and complex process in which DNA methylation plays a crucial role. This study aimed to explore the differential methylation profiles in sperm DNA between patients with asthenospermia (AS) and healthy controls (HCs), those with oligoasthenospermia (OAS) and HCs, and patients with AS and those with OAS. - Source: PubMed
Publication date: 2024/06/17
Zhang JingdiLi XiaogangWang RongrongFeng XinxinWang SiyuWang HaiWang YutaoLi HongjunLi YongzheGuo Ye