Ask about this productRelated genes to: EPRS Blocking Peptide
- Gene:
- EPRS NIH gene
- Name:
- glutamyl-prolyl-tRNA synthetase
- Previous symbol:
- QPRS, QARS
- Synonyms:
- EARS, PARS, GLUPRORS
- Chromosome:
- 1q41
- Locus Type:
- gene with protein product
- Date approved:
- 1991-02-20
- Date modifiied:
- 2014-11-18
Related products to: EPRS Blocking Peptide
Related articles to: EPRS Blocking Peptide
- Polygenic risk score values vary with genetic ancestry due to differences in population-specific allele frequencies and linkage disequilibrium patterns. We present a framework to calibrate polygenic risk scores based on ancestral makeup. We propose the "expected polygenic risk score" or ePRS, defined as the expected value of a polygenic risk score based on one's global or local admixture patterns. We further define the "residual polygenic risk score" or rPRS as measuring the deviation of the polygenic risk score from the ePRS. The ePRS reflects the baseline ancestry-driven component of genetic risk, whereas the rPRS isolates an ancestry-agnostic measure of genetic liability. Simulation studies confirm that it suffices to adjust for ePRS to obtain nearly unbiased estimates of the polygenic risk score-outcome association without further adjusting for principal components. Using the TOPMed and the All of Us datasets, effect size estimates for the rPRS (adjusted for ePRS) are similar to those obtained from polygenic risk scores adjusting for genetic principal components. The ePRS framework can protect from population stratification in association analysis and provide an equitable strategy to interpret genetic risk across diverse populations. - Source: PubMed
Publication date: 2026/04/30
Huang Yu-JyunKurniansyah NuzululGoodman Matthew OSpitzer Brian WWang JiongmingStilp AdrienneLaurie Ceceliade Vries Paul SChen HanMin Yuan-ISims MarioPeloso Gina MGuo XiuqingBis Joshua CBrody Jennifer ARaffield Laura MSmith Jennifer AZhao WeiRotter Jerome IRich Stephen SRedline SusanFornage MyriamKaplan RobertFranceschini NoraLevy DanielMorrison Alanna CBoerwinkle EricSmith Nicholas LKooperberg CharlesPsaty Bruce MZöllner Sebastian Sofer Tamar - Electronic patient records (EPRs) have shown potential to improve health care delivery, coordination, and patient engagement. In Switzerland, the development of a national EPR is supported by the Confederation, while its deployment is carried out by the cantons through EPR communities. Since health policy and the organization of health systems are entrusted to cantonal governments, each of the 26 Swiss cantons must decide its strategy for the implementation and application of EPRs within its jurisdiction. The canton of Vaud has joined with other French-speaking cantons (Geneva, Valais, Fribourg, and Jura) in organizing the implementation of the EPR through the CARA association since 2018. By June 2025, approximately 32,350 individuals have opened an EPR (Dossier électronique du patient) through CARA, accounting for 28% of all EPRs opened nationwide at that time. - Source: PubMed
Publication date: 2026/04/21
Bastardot FrançoisLaRocco CatherineRobert MathildeSchoeb Veronika - Nutritional interventions may reduce the prevalence of malnutrition in patients with head and neck cancer; however, implementation often fails due to barriers at various levels. Process evaluations can provide an understanding of implementation outcomes, mechanisms of impact, and context and provide information about feasibility and acceptability. - Source: PubMed
Publication date: 2026/03/21
Severinsen FridaVarsi CecilieAndersen Lene FrostHenriksen ChristinePaulsen Mari Mohn - To validate the FDS for predicting NSTEMI in Hong Kong EDs, assess score distribution, evaluate its accuracy in triaging NSTEMI cases and identify the optimal cutoff for clinical use. - Source: PubMed
Lui Hiu Yi NicoleLun Yin YanWong Ching ManMak Yuk Ying EmilyNg King TingChan Chun HoWong Ka Wun - The aim of this study was to determine which mycological diagnostic test(s) and clinical data are required for detecting and classifying Aspergillus disease cases for surveillance purposes. - Source: PubMed
Publication date: 2026/03/19
van Grootveld Rvan der Beek M TBuil J BSchoffelen A Fde Greeff S CBosch Tde Boer M G JKuijper E JVerweij P E