Ask about this productRelated genes to: MAOB Blocking Peptide
- Gene:
- MAOB NIH gene
- Name:
- monoamine oxidase B
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- Xp11.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
Related products to: MAOB Blocking Peptide
Related articles to: MAOB Blocking Peptide
- Breast cancer exhibits high heterogeneity and drug resistance, presenting severe challenges in clinical treatment. - Source: PubMed
Publication date: 2026/05/08
Ye XuqinShao Gang - Oxidative stress (OS) is a key factor in the degeneration of dopaminergic neurons in Parkinson's disease (PD). It is closely associated with mitochondrial dysfunction, overproduction of reactive oxygen species (ROS), neuroinflammation, and excitotoxicity mediated by nitric oxide (NO). These mechanisms underscore OS as a crucial therapeutic target. This study investigated the molecular interaction of tricin with OS-related targets and validated its antioxidant potential. - Source: PubMed
Publication date: 2026/05/05
Giri SushilChandra Phool - The present study aimed to investigate neuroprotective potential of wogonin in rotenone-induced PD, with particular focus on modulation of excitatory/inhibitory (E/I) neurotransmission and other pathological factors, including oxidative stress, neuroinflammation, and apoptosis. - Source: PubMed
Publication date: 2026/05/07
Chib ShivaniDutta Bhaskar JyotiSingh Randhir - Alzheimer's disease (AD) is an irreversible neurodegenerative disorder characterised by progressive cognitive decline, neuronal loss and accumulation of β-amyloid plaques and neurofibrillary tangles. Even after many years of intensive research, scientists still have not found a cure for AD. The current medications can only help to manage the symptoms of AD or slow down the disease progression. This highlights an urgent and unmet need for the development of novel therapeutic agents capable of simultaneously modulating the multifactorial pathological pathways that drive the onset and progression of AD. The multitarget-directed ligand approach has garnered considerable attention in this context, aiming to simultaneously modulate multiple disease-relevant targets, including AChE, BChE, MAO-A and MAO-B, BACE1, and oxidative stress mediators. Indole, a fortunate heterocyclic scaffold, has become a valuable tool for the design and development of multi-target directed ligands in anti-Alzheimer drug discovery due to its favourable physicochemical properties, BBB permeability and medicinal attributes. This review summarises recent advancements in the medicinal chemistry of indole hybrids as anti-Alzheimer agents, highlighting the impact of structural modifications on biological activity, including the underlying molecular mechanisms, structure-activity relationships, and computational studies. The findings summarised in the article can pave the way for future anti-Alzheimer drug discovery. - Source: PubMed
Bagul Akshad DIrfan MohdJaitak AashishAsati VivekGoyal KamyaMonga Vikramdeep - 'Kava,' or 'kava kava,' (Piper methysticum) is a psychoactive plant indigenous to the Pacific Islands. Historical consumption is reported to provide anxiolytic and sedating effects. In regions where kava is native, it has been used in religious and cultural practices, as well as for medicinal purposes. The mechanisms by which kavalactones - the best studied psychoactive constituent of kava - may mediate pharmacological effects include enhancing the GABA receptor, blocking of sodium and calcium channels, blocking reuptake of norepinephrine dopamine, and inhibiting MAO-B. In the United States, products containing kava have proliferated in recent years alongside the rise of ethnobotanical tea bars serving kava preparations. - Source: PubMed
Publication date: 2026/05/05
Hill KatherinePiercey CiannaKaroly Hollis CSmith Kirsten E