Ask about this productRelated genes to: CTSE Blocking Peptide
- Gene:
- CTSE NIH gene
- Name:
- cathepsin E
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-19
- Date modifiied:
- 2015-09-11
Related products to: CTSE Blocking Peptide
Related articles to: CTSE Blocking Peptide
- Gradient copolymers, which feature a gradual transition in monomer composition along the polymer backbone, uniquely combine tunable material properties with inherent stochasticity at the molecular level, bridging the structure-property landscape between block and random copolymers. Their broad glass transition temperature range, self-assembly potential, and amphiphilic behavior, if they consist of hydrophilic and hydrophobic comonomer units, enable applications in damping materials, drug delivery, and cosmetics. Moreover, they are interesting potential substitutes for block copolymers based on their much simpler and cheaper production process. However, gradient copolymers are not as simple as often presumed because they emerge from less trivial monomer inclusion probability profiles that are determined by monomer reactivity ratios and/or feeding profiles. As a result, gradient copolymers exhibit significant compositional heterogeneity, even under idealized conditions (fast chain initiation; no side reactions; and no diffusional limitations). This perspective highlights the critical importance of compositional control and structural evaluation in gradient (tapered) copolymer synthesis, highlighting the relevance of calculating a set of structural deviation (SD) metrics using coupled matrix-based Monte Carlo (CMMC) simulations to assess structural quality. In parallel to experimental protocol development and design, SD metrics such as the average SD (⟨SD⟩), SD standard deviation (σ), SD skewness ( ), and coefficient of variation (CV) can be used to assess whether improved synthesis protocols are worthwhile or not. For a given synthesis recipe, a simultaneous SD evaluation with respect to block, gradient, block-gradient, and block-gradient-block targets is recommended based on a framework calibrated on the individual chain level. This facilitates the identification of the application scope of both exploratory and systematic research on gradient copolymer synthesis approaches. - Source: PubMed
Publication date: 2026/03/06
Conka RobertMarien Yoshi WVan Geem Kevin MVan Steenberge Paul H MHoogenboom RichardD'hooge Dagmar R - Colorectal cancer (CRC) is a leading malignant tumor worldwide with rising morbidity and mortality. Cathepsin E (CTSE), a member of the cysteinyl asparaginase family, is implicated in immune responses, antigen processing, and cellular signaling. - Source: PubMed
Publication date: 2026/03/14
Zhang HuanFeng JieZhu MengxinShi TongguoXi Qinhua - Dysregulation of melanin contributes to pigmentation disorders including vitiligo, which lacks effective and safe therapeutic options. Despite advances in immunomodulatory therapies, current treatments often fail to address both the loss of melanocytes and the underlying autoimmune pathology driving the disease. Clematis tangutica (Maxim.) Korsh. (C. tangutica), a traditional Chinese Tibetan medicine adapted to high-altitude UV stress, remains unexplored in pigment regulation. - Source: PubMed
Publication date: 2026/02/12
Guo MiaoPeng JingfengDong ChangshengLu JihongLi SuntaoChen MoZhu JianzhengChen AnyingLu YuqiJing LiliXiao HuaFu DongmeiLiang XinmiaoZhang Yan - Bladder cancer (BC) is significantly more prevalent in men than in women, yet female patients often experience higher recurrence rates and poorer prognosis. - Source: PubMed
Publication date: 2026/02/09
Zeber-Lubecka NataliaBilski KonradDąbrowska MichalinaGoryca KrzysztofZiemska-Legięcka JoannaOstrowski JerzyDobruch JakubHennig Ewa E - Cardiopulmonary diseases, encompassing cardiovascular and pulmonary disorders, represent a major global health burden, with cathepsins (CTSs) - proteases involved in extracellular matrix degradation and inflammation - have established causal links to cardiovascular disease, but their roles in lung pathologies like idiopathic pulmonary fibrosis (IPF) remain uncertain. We performed bidirectional Mendelian randomization (MR) to assess causal relationships between plasma levels of 11 CTSs and 10 common cardiopulmonary diseases. Heterogeneity and horizontal pleiotropy were evaluated using Cochran's Q test and MR-Egger intercept, respectively. Protein-protein interaction networks were analyzed via STRING, and Bayesian colocalization tested for shared causal variants underlying CTS interactions and CTS-disease associations. Bidirectional MR identified CTSH as a protective factor for IPF (inverse variance weighted odds ratio: 0.885, 95% confidence interval: 0.827-0.947, P = 3.86 × 10⁻⁴), with no reverse causality detected; STRING analysis revealed CTSH interactions with CTSL and CTSD; Bayesian colocalization yielded posterior probabilities (PPH4) of 0.0336 (CTSH-CTSD), 0.0477 (CTSH-CTSL), and 0.7955 (CTSH-IPF). Nominal causal associations were observed between CTSE and cardiovascular diseases, and between myocardial infarction and CTSL/CTSO/CTSZ, though these require further validation. Our findings genetically support CTSH as a protective factor against IPF, highlighting its potential as a therapeutic target. Further studies are needed to validate additional CTS-disease associations. - Source: PubMed
Zhang ChunfuXu BeiqiYu TianlunHe FangkaiHang FangjieQian Wei