Ask about this productRelated genes to: MAPK15 Blocking Peptide
- Gene:
- MAPK15 NIH gene
- Name:
- mitogen-activated protein kinase 15
- Previous symbol:
- -
- Synonyms:
- ERK8, ERK7
- Chromosome:
- 8q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-04-05
- Date modifiied:
- 2014-11-18
Related products to: MAPK15 Blocking Peptide
Related articles to: MAPK15 Blocking Peptide
- - Source: PubMed
Publication date: 2026/04/24
Li JuanChen GangBao Xinyi - Liangshan Meigu Yanying chicken is an indigenous high-altitude breed in Sichuan, China, but its population genetic structure and the genetic basis of key growth and meat-quality traits remain unclear. In this study, 211 Meigu Yanying chickens were whole-genome resequenced, and leg muscle weight, liver weight, leg muscle total protein content and leg muscle total cholesterol content were recorded at slaughter. After quality control, high-confidence single-nucleotide polymorphisms were used to analyze linkage disequilibrium, population structure and genome-wide associations. Linkage disequilibrium decayed rapidly with distance, and multivariate analyses indicated an overall homogeneous genetic background with only mild substructure and few closely related individuals. Genome-wide association studies for the four traits detected several significant or suggestive regions harboring biologically plausible candidate genes, including CPNE4, PLXNB2, SMAP1, SDHAF4, FAM135A, LCP1, MAPK15 and SCRIB. Gene Ontology enrichment showed that candidate genes for leg muscle weight and liver weight were mainly involved in cellular processes and tissue development, whereas those for leg muscle total cholesterol content were enriched in phosphorus metabolism and phosphate-containing compound metabolism. These results provide a genome-wide resource for Meigu Yanying chickens and lay a basis for conservation and genomic breeding aimed at improved growth performance, meat quality and nutritional value. - Source: PubMed
Publication date: 2026/02/09
Hu YaodongCai BinjianLi TianyuTang ShiWang SiluSun CaiyunChen BinlongRen Peng - Accumulation of lipids in the liver characterizes metabolic dysfunction-associated steatotic liver disease (MASLD), the most prevalent chronic liver disease worldwide. - Source: PubMed
Publication date: 2026/01/29
Inzalaco GiovanniGargiulo SaraBonente DeniseGherardini LisaFranci LorenzoLorito NiclaDel Turco SerenaTatoni DaniloTamborrino TizianaGalvagni FedericoBertelli EugenioD'Aurizio RominaAndreassi Maria GraziaBasta GiuseppinaGastaldelli AmaliaMorandi AndreaBarone VirginiaChiariello Mario - Feeding behavior is a fundamental biological process closely linked to development, growth, metabolism, and immune regulation in animals. In livestock production, it serves as both an indicator of health status and a selection criterion for breeding programs aimed at improving feed efficiency and adaptive behavior. However, the genetic basis and regulatory mechanisms governing these traits remain poorly understood. In this study, we investigated the genomic architecture of feeding behavior in 205 slow-growing yellow broilers using whole-genome sequencing and high-resolution behavioral phenotyping recorded by automated feeders. Six feeding behavior traits - average daily feed intake, number of daily visits, daily feeding duration, feeding duration per visit, feed intake per visit, and feeding rate - along with 17 production traits in 205 slow-growing yellow broilers were analyzed. SNP-based heritability estimates ranged from 0.30 to 0.69, indicating moderate to high genetic control. Phenotypic and genetic correlations showed significant positive correlations with residual feed intake, suggesting their potential as breeding indicators of feed efficiency. Genome-wide association studies (GWAS) identified seven single nucleotide polymorphisms (SNPs) and three structural variants (SVs) significantly associated with time-related and intake-related feeding traits. Functional annotation and regulatory element prediction highlighted candidate genes, including SMARCC1, SLC15A2, SEMA5B, LRIG1, ARHGAP39, HSPBAP1, and MAPK15, which, based on public databases, were expressed across multiple tissues but showed relatively higher levels in neuro-related tissues, with the retina emerging as a common site of high expression. These genes are involved in chromatin remodeling, neuropeptide transport, retinal development, and stress response, supporting a potential regulatory role of the brain-retina axis in feeding behavior. Together, our findings identify candidate genomic loci and biological pathways associated with feeding behavior, providing new insights into the neural regulation of appetite and valuable molecular targets for genetic improvement of feed efficiency and animal welfare in poultry breeding. - Source: PubMed
Publication date: 2026/01/12
Wang PingZhai ShuangshuangZhao YangDai YuchiLi ChengxuanZheng YingyingMa ChunmeiYang NingYan Wei - Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most common chronic liver disorders worldwide and can lead to inflammation, fibrosis, and liver cancer. To better understand the impact of an unbalanced hypercaloric diet on liver phenotype in impaired autophagy, the study compared C57BL/6J wild type (WT) and MAPK15-ERK8 knockout (KO) male mice with C57BL/6J background fed for 17 weeks with "Western-type" (WD) or standard diet (SD). Liver features were monitored in vivo by high-frequency ultrasound (HFUS) using a semi-quantitative and parametric assessment of pathological changes in the parenchyma complemented by computer-aided diagnosis (CAD) methods. Liver histology was considered the reference standard. WD induced liver steatosis in both genotypes, although KO mice showed more pronounced dietary effects than WT mice. Overall, HFUS reliably detected steatosis-related parenchymal changes over time in the two mouse genotypes examined, consistent with histology. Furthermore, this study demonstrated the feasibility of extracting quantitative features from conventional B-mode ultrasound images of the liver in murine models at early clinical stages of MASLD using a computationally efficient and vendor-independent CAD method. This approach may contribute to the non-invasive characterization of genetically engineered mouse models of MASLD according to the principles of replacement, reduction, and refinement (3Rs), with interesting translational implications. - Source: PubMed
Publication date: 2025/10/17
Gargiulo SaraGramanzini MatteoBonente DeniseTamborrino TizianaInzalaco GiovanniGherardini LisaFranci LorenzoBertelli EugenioBarone VirginiaChiariello Mario