Ask about this productRelated genes to: PAOX Blocking Peptide
- Gene:
- PAOX NIH gene
- Name:
- polyamine oxidase
- Previous symbol:
- -
- Synonyms:
- PAO
- Chromosome:
- 10q26.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-13
- Date modifiied:
- 2016-08-11
Related products to: PAOX Blocking Peptide
Related articles to: PAOX Blocking Peptide
- Bladder cancer (BC) frequently recurs after standard surgical resection and is often associated with poor survival outcomes. Local treatment via intravesical instillation of drug is a promising strategy, but its therapeutic efficacy is limited by insufficient retention time and urinary tract obstruction. We demonstrate that BC exhibits pronounced suppression of acetylpolyamine oxidase (PAOX) compared to normal tissues, as evidenced by multi-platform analysis of patient-derived clinical specimens and GEO database. The PAOX deficiency drives pathological polyamine accumulation in BC cells, uncovering a novel metabolic target with therapeutic implications. Thus, we engineered a novel intravesical instillation system that combines PAOX/targeting peptide-conjugated nanoparticles, synergistically boosting reactive acrolein synthesis while blocking detoxification to induce lethal carbonyl stress, and reverse temperature hydrogels, ensuring liquid dispersion for full bladder coverage during instillation, followed by gelation to prolong nanoparticle retention. and results showed that this nanoparticle-embedded hydrogel disrupt redox homeostasis by amplifying lethal carbonyl stress via mitochondrial dysfunction, lipid peroxidation and DNA damage. Remarkably, acrolein binding to GAPDH promotes its nuclear translocation and upregulation of the tumor suppressor protein P53, facilitating apoptosis. This innovative strategy enhances reactive acrolein accumulation by targeting tumor-specific metabolic vulnerabilities, inducing multifaceted cell death for the BC treatment. - Source: PubMed
Publication date: 2026/01/01
Xu YingyingDu QinglongZhao ZhongweiFu ShuaiZhang AijingZheng JianguoZhao ChengyangMeng YuxiangLiu HanruLv ZongyaoQin XinGeng HuiminYu Nengwang - Porous ordered anodic alumina (PAOX) is a textbook example of macroscopic self-organization. It is often regarded as a blueprint of a dissipative structure, characterized by its highly ordered pore appearance formed by electrohydrodynamic processes and related flow cells. Considering the pores and flow cells, our findings reveal for the first time that the collective development of these macroscopic bodies into hexagonal arrangements follows quantum mechanical rules. The extremal principles and laws which govern the arrangement symmetry are herein conceptually connected to eigenenergies, eigenenergy-spectra and properties of fermionic particles, and hence they form a discrete entropy production spectrum which encodes the distribution of coordination environments. These quantum mechanical aspects are embedded into a model of PAOX order evolution based on entropy production and the theory of dissipative structures. - Source: PubMed
Publication date: 2025/12/05
Heinschke SilvioSchneider Jörg J - Spermine oxidase (SMOX) is associated with pathological processes in cancer initiation and progression, driving interest in the search for SMOX inhibitors. Currently available inhibitors exhibit moderate activity and limited selectivity toward other polyamine-metabolizing enzymes such as polyamine oxidase (PAOX), underscoring the urgent need for potent and selective inhibitors of SMOX. This study focuses on the optimization of a series of pyrazolopyrimidines, leading to the discovery of JNJ-9350 as a potent inhibitor of human SMOX (hSMOX) with unprecedented selectivity over other polyamine enzymes such as hPAOX. Importantly, JNJ-9350 displays remarkable intracellular target engagement and inhibition in cellular assays, positioning JNJ-9350 as a suitable tool compound for cellular experiments to further validate the potential of SMOX inhibitors as anticancer therapeutics. - Source: PubMed
Publication date: 2025/10/27
Llaveria JosepAdhikary SurajBuyck ChristopheCañellas SantiagoCid Jose MariaDanna BenDelgado FranciscaDiaz ElsieDiéguez-Vázquez AlejandroFang LichaoFernandez Candelaria Froylan OmarGibbons GarrettA Klaren Vincent NKrosky Daniel JImpagliazzo AntoniettaLinares Maria LourdesLamenca Carolina MartinezMisale AntonioPryor MeghanShang JackieSuarez Javier - The formation of interpolymer complexes (IPCs) between poly(2-alkyl-2-oxazolines) (PAOx) and poly(methacrylic acid) (PMAA) in solutions has been investigated using polarized luminescence relaxation and small-angle X-ray scattering (SAXS) structural methods. The results reveal that hydrophobic interactions contribute to the formation of IPCs in both aqueous and methanol solutions, influenced by the length of the side group in PAOx. The relaxation times, which can be used to quantify the intramolecular mobility of the luminescently labeled poly(methacrylic acid) (PMAA*), increase from 80 to 680 ns, indicating the formation of IPCs between PMAA* and PAOx. SAXS analysis of aqueous IPC solutions unveils their supramolecular organization, which is similar to that of nanohydrogels, with the hierarchical level comprising compact structures ranging from 4 to 10.7 nm in size. - Source: PubMed
Publication date: 2025/06/13
Smyslov Ruslan YGorshkova Yulia ENekrasova Tatiana NMakhayeva Danelya NMun Grigoriy AIrmukhametova Galiya SKhutoryanskiy Vitaliy V - The impact of SARS-CoV-2 infection on thyroid cancer at the genomic level remains poorly understood. The purpose of our study was to determine whether significant DNA methylation changes occur in thyroid cancer tissues from patients with recent SARS-CoV-2 infection. Surgically resected normal thyroid and Papillary (PTC) tissues from three COVID-19-infected PTC patients (Cases) and three prepandemic PTC patients (Controls) were analyzed using DNA methylation EPIC arrays. Differentially methylated probes (DMPs) and differentially methylated regions (DMRs) were identified in normal thyroid and PTC tissues. Functional enrichment analysis was subsequently performed to explore the affected pathways. COVID-19-infected PTC tissues presented distinct DNA methylation profiles, with 6,848 DMPs in PTC tissues compared with 140 in normal thyroid tissues. SARS-CoV-2 infection did not significantly affect normal thyroid tissue by methylation. SARS-CoV-2 infection in PTC tissues was associated with hypermethylation of tumor suppressor genes (RUNX3, PAOX), the Wnt signaling pathway, the HOX gene family, cell adhesion-related genes and hypomethylation in response to virus-related genes. The key DMRs identified in PTC included GPR75, CCDC80, and ENTPD3, suggesting altered cell adhesion, tumor proliferation, and immune evasion. SARS-CoV-2 infection is linked to significant DNA methylation alterations in PTC tissues, with potential implications for tumor progression and aggressiveness. These findings suggest that COVID-19 may influence thyroid cancer biology. Further research is needed to validate these epigenetic modifications, establish causal relationships and determine their clinical relevance. - Source: PubMed
Publication date: 2025/06/09
Ahn Jong-HyukYi Jin Wook