Ask about this productRelated genes to: NSUN3 Blocking Peptide
- Gene:
- NSUN3 NIH gene
- Name:
- NOP2/Sun RNA methyltransferase 3
- Previous symbol:
- -
- Synonyms:
- FLJ22609
- Chromosome:
- 3q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-08-25
- Date modifiied:
- 2019-02-26
Related products to: NSUN3 Blocking Peptide
Related articles to: NSUN3 Blocking Peptide
- Osteoarthritis (OA) is a degenerative joint disease, with chondrocyte ferroptosis a key pathogenic mechanism in its progression. The role of RNA 5-methylcytosine (m5C) modification in OA chondrocyte ferroptosis remains unclear. This study investigates the involvement and mechanisms of m5C-related regulatory factors in OA chondrocyte ferroptosis. - Source: PubMed
Publication date: 2026/05/08
Mahan WuluhanAyiheng YelinaerXie Zengru - Oral squamous cell carcinoma (OSCC) is a prevalent malignancy with high rates of lymph node metastasis and recurrence, contributing to persistently poor clinical outcomes. RNA 5-methylcytosine (mC) modification, mediated by methyltransferases such as NSUN3, is implicated in tumor progression; however, the specific function of NSUN3 in OSCC remains largely unexplored. Autophagy plays a dual role in cancer, and the FOXO pathway is a key regulator of autophagy. This study aimed to elucidate the function of NSUN3 in OSCC and its potential mechanism involving autophagy and FOXO signaling. - Source: PubMed
Publication date: 2026/04/22
Wang ChengtaoCheng LangWang LeiLuo TaoXie YuxinChen JunliangWu Shuangjiang - encodes a mitochondrial RNA methyltransferase responsible for cytosine methylation at the tRNA wobble base, which plays a role in the regulation of mitochondrial translation. Variants in lead to impaired oxidative phosphorylation resulting in multisystem involvement. Reported cases to date have described developmental delay, hypotonia, optic atrophy and neurological involvement. Cardiac manifestations, however, have not yet been clearly associated with deficiency. Here, we report hypertrophic cardiomyopathy (HCM) as a new clinical feature and the long-term follow-up of our case, further expanding the phenotype of -related disease. - Source: PubMed
Publication date: 2026/02/24
Şenol Ersak AyşeÇağıran TuğçeKoçyiğit AyşenÇıkı KısmetYıldız YılmazAypar EbruKetenci İşlek SerapŞimşek Kiper Pelin ÖzlemHaliloğlu GöknurDursun Ali - Atherosclerosis (AS) is a chronic inflammatory disease with a poor prognosis, and 5-methylcytosine (m5C) RNA modification plays a significant role in AS-induced cardio-cerebrovascular diseases (CCVDs). However, the effects of m5C modification and related genes in AS remain unclear. - Source: PubMed
Publication date: 2026/01/09
Zhao HuiKong YingDing PengfeiYang LuqunLi Ning - 5-Methylcytosine (m5C) methylation is a widely present nucleic acid modification in various RNAs and is a reversible epigenetic modification that affects RNA stability, nuclear export, and translation processes. Methylation writers are responsible for adding methyl groups to RNA molecules, regulating gene expression and cellular function through catalyzing methyl transfer reactions. In order to more intuitively demonstrate the important value of NOL1/NOP2/SUN domain (NSUN) family genes in both tumor and non-tumor diseases, we conducted a relevant review. The NSUN family genes (NSUN1/NOP2, NSUN2, NSUN3, NSUN4, NSUN5, NSUN6, NSUN7) are the main writers of m5C methylation. These genes can regulate methylation and affect the expression of other genes and are important in tumor and non-tumor diseases. Pieces of research on 7 NSUN family genes regarding methylation, diagnostic value, inflammatory diseases, cancer, and other diseases were searched for and summarized separately. Differences in NSUN family genes have been observed in many cancers, which can affect tumor growth, metastasis, chemotherapy resistance, and m5C methylation. In addition to affecting cancer, NSUN family genes have also attracted widespread attention due to their involvement in diseases related to growth, development, and metabolism. NSUN2 is the most studied NSUN family gene, which exhibits cancer promoting effects in various cancers such as lung cancer, liver cancer, and colorectal cancer. This review provides an overview of the roles of NSUN family genes in methylation, diagnostic value, inflammatory diseases, cancer, and other diseases. - Source: PubMed
Publication date: 2025/11/30
Jiang TaoJiang NiliChen XuanXiong Zuming