Ask about this productRelated genes to: BHMT2 Blocking Peptide
- Gene:
- BHMT2 NIH gene
- Name:
- betaine--homocysteine S-methyltransferase 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 5q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-08-27
- Date modifiied:
- 2016-10-05
Related products to: BHMT2 Blocking Peptide
Related articles to: BHMT2 Blocking Peptide
- Background Necrotizing enterocolitis (NEC) is a devastating intestinal disorder in premature infants, characterized by inflammation and tissue injury. Identifying key regulatory pathways contributing to NEC pathogenesis is essential for developing targeted therapeutic strategies. Methods Transcriptomic analysis of NEC and control samples identified a core regulatory module comprising AHSG, BHMT2, and MAT1A. Their expression and functional roles were investigated in human primary intestinal epithelial cells (HPIECs), a transwell co-culture system with THP-1 macrophages, and a mouse model of NEC. Molecular techniques, including RT-qPCR, Western blotting, ELISA, chromatin immunoprecipitation, and flow cytometry were employed to decipher the functional mechanism of this regulatory module. Results AHSG, BHMT2, and MAT1A were upregulated in NEC samples and LPS-stimulated HPIECs. BHMT2 and MAT1A regulated AHSG expression through S-adenosylmethionine production and histone methylation. In the co-culture system, silencing BHMT2, MAT1A, or AHSG in LPS-stimulated HPIECs attenuated M1 macrophage polarization, inflammatory cytokine production, and invasive capacity of THP-1 cells. Conversely, overexpressing these genes in HPIECs promoted M1 macrophage activation. In the NEC mouse model, targeting BHMT2, MAT1A, or AHSG alleviated intestinal tissue damage, inflammation, and M1 macrophage polarization. Conclusion The BHMT2/MAT1A/AHSG axis in intestinal epithelial cells orchestrates M1 macrophage activation and contributes to the exacerbation of NEC. Targeting this pathway may represent a potential therapeutic strategy for NEC management. - Source: PubMed
Publication date: 2025/11/11
Yue WanyongLu XinghengTian WenmeiZhang FeiNong GuowangPan GuangzeZhang XueliangYu Guodan - Congenital heart disease (CHD) poses significant clinical challenges due to limitations in early prenatal diagnosis. This study aimed to identify serum metabolic biomarkers for CHD using a combined metabolomics approach. Serum samples from 55 pregnant women carrying fetuses with confirmed CHD (CHDP group) and 49 healthy controls (ZCP group) were analyzed via non-targeted HNMR metabolomics, revealing distinct metabolic profiles. Six choline pathway metabolites were further quantified by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Among these, N,N-dimethylglycine (DMG) exhibited the most significant reduction in the CHDP group (1.07 ± 0.03 vs. 1.55 ± 0.04 µg/mL, p < 0.001), with an area under the ROC curve (AUROC) of 0.883 in the discovery cohort. Validation in an independent cohort (58 CHDP vs. 62 ZCP) confirmed DMG's diagnostic potential (AUROC = 0.818). While betaine-homocysteine methyltransferase 2 (BHMT2) activity showed no intergroup differences, DMG's consistent performance highlights its utility as a non-invasive biomarker. This study underscores the clinical value of metabonomics in prenatal CHD screening and establishes DMG as a promising diagnostic marker, potentially improving early detection and perinatal management. - Source: PubMed
Publication date: 2025/08/27
Xie BaogangZhan DujuanWu LeWang LeleLei YongrongLiu MengLiu XiaodanLi Suping - Evidence of the benefits of cordycepin (Cpn) for treating obesity is accumulating, but detailed knowledge of its therapeutic targets and mechanisms remains limited. This study aimed to systematically identify Cpn's therapeutic targets and pathways in Western diet (WD)-induced obesity using integrated network pharmacology, transcriptomics, and experimental validation. - Source: PubMed
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Bao ChunjieChen HongZhou HaoliangChen Feng - Patients with aggressive HCC have limited therapeutic options. Therefore, a better understanding of HCC pathogenesis is needed to improve treatment. Genomic studies of HCC have improved our understanding of cancer biology. However, the ubiquitomic characteristics of HCC remain poorly understood. We aimed to reveal the ubiquitomic characteristics of HCC and provide clinical feature biomarkers of the aggressive HCC that may be used for diagnosis or therapy in the clinic. - Source: PubMed
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