Ask about this productRelated genes to: GABRG2 Blocking Peptide
- Gene:
- GABRG2 NIH gene
- Name:
- gamma-aminobutyric acid type A receptor gamma2 subunit
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 5q34
- Locus Type:
- gene with protein product
- Date approved:
- 1991-02-26
- Date modifiied:
- 2016-02-04
Related products to: GABRG2 Blocking Peptide
Related articles to: GABRG2 Blocking Peptide
- BackgroundAcetyl tributyl citrate (ATBC), an eco-friendly plasticizer, exhibits poorly characterized neurotoxic effects.ObjectiveWe integrated network toxicology, machine learning, and molecular docking to elucidate molecular mechanisms underlying the link between ATBC exposure and Alzheimer's disease (AD) pathogenesis.MethodsPotential action targets of ATBC were screened from ChEMBL, TargetNet, and SwissTarget Prediction databases; disease-associated targets were derived from differential expression analysis of GEO datasets. Overlapping candidates underwent protein-protein interaction network construction (STRING) and subsequent Gene Ontology (GO)/Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. Machine learning employing SHAP prioritized pivotal targets, while molecular docking and dynamics simulations validated binding affinities.ResultsWe identified 68 shared targets, of which five were designated as critical (CCKBR, RAF1, GABRG2, STS, RAPGEF3). GO enrichment revealed that ATBC compromises neuronal function and synaptic plasticity by perturbing glial cell differentiation, synaptic transmission, benzodiazepine receptor activity, and serine/threonine kinase activity. KEGG analysis implicated neuroactive ligand-receptor interactions, calcium, FoxO, and PI3K-Akt signaling pathways. Molecular simulations confirmed stable compound-target binding.ConclusionsThis integrative computational approach elucidates mechanisms underlying plasticizer-associated neurotoxicity in AD, establishing a framework for investigating neurological impacts of environmental contaminants. - Source: PubMed
Publication date: 2026/03/13
Peng TaoXu PeiliGuo XiaofangLin JianZhang MengfanLiu XinghuaYe JianglinLin Xingdong - - Source: PubMed
Publication date: 2026/03/09
Naveed MuhammadHanif NimraAziz TariqWaseem MuhammadAlharbi MetabAlshammari AbdulrahmanAlasmari Abdullah F - Epilepsy syndromes show marked clinical and genetic heterogeneity, with numerous functionally diverse genes involved in their etiology. Next-generation sequencing (NGS) has facilitated the identification of many monogenic epilepsy syndromes and enables earlier, more accurate diagnosis in pediatric patients. This study analyzes the molecular profiles of 87 pediatric patients with various forms of epilepsy in whom pathogenic or likely pathogenic variants were identified. Next-generation sequencing (NGS) using multi-gene epilepsy panels or whole-exome sequencing (WES) was performed. A total of 88 pathogenic or likely pathogenic variants were detected in 48 epilepsy-related genes; 30 variants occurred de novo. and were the most frequent contributors (12.6% and 9.2%, respectively). The highest percentage of positive diagnoses (48%) was observed in patients with developmental and epileptic encephalopathy (DEE), with variants identified in genes including , , , , , , , , , , , , , , , , and . Pathogenic variants in were found in four patients with KBG syndrome, while other genes appeared sporadically. Targeted massively parallel sequencing is an effective diagnostic tool for pediatric epilepsy. The presence of numerous single-case findings highlights the high genetic heterogeneity of epilepsy. This approach enabled more precise diagnoses that would not have been achieved through clinical evaluation alone, underscoring the importance of genetic testing for prognosis and treatment planning in pediatric patients with unexplained epilepsy. - Source: PubMed
Publication date: 2026/01/27
Chałupczyńska BeataCiara ElżbietaHalat-Wolska PaulinaPollak AgnieszkaStawiński PiotrJurkiewicz DorotaPiekutowska-Abramczuk DorotaGawlik MarzenaPietrasik JustynaCieślikowska AgataWicher DorotaUlatowska AgataJedlińska DominikaBorkowska JulitaChmielewski DariuszDunin-Wąsowicz DorotaKotulska-Jóźwiak KatarzynaChrzanowska KrystynaMadej-Pilarczyk Agnieszka - Dravet syndrome (DS) is a developmental and epileptic encephalopathy caused mainly by SCN1A variants, several other genes have been implicated in DS-like phenotype. - Source: PubMed
Publication date: 2026/01/30
Tian XiaojuanCheng MiaomiaoYang YingZeng QiChen YiLiu AijieYang XiaolingZhang JingTan QuanzhenLiu WenweiWang TingOuyang ShijiaLiu ChanghaoWu YeJiang YuwuZhang Yuehua - - Source: PubMed
Chen Chih-Ping